Protein Alignment nAChRbeta1 and LOC100494266

DIOPT Version :10

• Sequence 1: NP_523927.2
• Gene: nAChRbeta1 / 38545
• FlyBaseID: FBgn0000038
• Length: 521
• Species: Drosophila melanogaster
• Sequence 2: XP_002932551.2
• Gene: LOC100494266 / 100494266
• XenbaseID: XB-GENE-29082107
• Length: 457
• Species: Xenopus tropicalis
• Alignment Length: 500
• Identity: 115/500 - (23%)
• Similarity: 216/500 - (43%)
• Gaps: 98/500 - (19%)

  Fly    10 LCSIL-VLVAFSLVSASEDEERLVRDLFRGYNKLIRPVQNMTQKVGVRFGLAFVQLINVNEKNQI 73
            :||:. ||...||.|            ..|.|  ||||:|......|...:....:::::..:|.
 Frog    23 ICSLNDVLQNISLAS------------IPGAN--IRPVKNWQTPSEVFIHVTLYSIVSLDTSSQT 73

  Fly    74 MKSNVWLRLVWYDYQLQWDEADYGGIGVLRLPPDKVWKPDIVLFNNA---DGNYEVRYKSNVLIY 135
            :.:.:||.|.|.:..:.|:..|:..|..:....|.:||||:.::...   |.|..:.|   ..|.
 Frog    74 LTTYIWLYLKWKNEFISWNPVDFCDIDEVTSLGDTLWKPDLYIYQLVEPDDKNPVIPY---YRIQ 135

  Fly   136 PTGEVLWVPPAIYQSSCTIDVTYFPFDQQTCIMKFGSWTFNGDQVSLALYNNKNFV---DLSDYW 197
            ..|:::...|....|||.|::..||||.|||.:.|||:.:..:.:.:....|.:.|   .|..:.
 Frog   136 NDGDIVSSKPLRIISSCNINIFKFPFDTQTCNLTFGSFIYTVEDIIMFPSLNSSEVSQLSLDSFV 200

  Fly   198 KSGTWDIIEVPAYLNVYEGDSNHPTETDITFYIIIRRKTLFYTVNLILPTVLISFLCVLVFYLPA 262
            ..|.|.:::|........||...   :::|:.|.::|.::.:.:|||:|...:.||.....::
 Frog   201 SKGDWSLLDVAVVNQSLVGDGQF---SEVTYMITMKRSSVVFVINLIVPACFLIFLDFASMFI-- 260

  Fly   263 EAGEKVTLGISILLSLVVFLLLVSKILPPTSLVLPLIAKYLLFTFIMNTVSIL---VTVIIINWN 324
            ..||.:...|:|:|...|.||:::.:: |:|...|::..:.:....:..:|||   :|..::..:
 Frog   261 RIGETLEFKITIVLGFSVLLLILNDMM-PSSDNPPMLGIFCVVCLAIMVISILGCILTNYMLTLS 324

  Fly   325 FRGPRTHRMPMYIRSIFLHYLPAFLFMKRPRKTRLRWMMEM---PGMSMPAHPHPSYGSPAELPK 386
            ...|   .:|.:|:::.|.:|...||.|. .|.....::.:   ||:|      .:|..|.
 Frog   325 DMQP---NVPNWIKTLILKHLARILFFKL-YKNEQNLVVSVDTDPGVS------KAYNQPD---- 375

  Fly   387 HISAIGGKQSKMEVMELSDLHHPNCKINRKVNSGGELGLGDGCRRESESSDSILLSPEA---SKA 448
                          |||.                         :::.:|...|.::||.   .|.
 Frog   376 --------------MELQ-------------------------KKKKDSDKEIKITPEVRLLKKL 401

  Fly   449 TEAVEFIAEHL---RNEDLYIQTREDWKYVAMVIDRLQLYIFFIV 490
            .:.|..|.::|   :||.   ..:.:|...|:|:|||.|:::.|:
 Frog   402 LDEVLKINQNLKLSKNEQ---DAKSEWYMAALVVDRLILFLYLII 443

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRbeta1	NP_523927.2	LIC	8..500	CDD:455710	115/499 (23%)
		LGIC_ECD_nAChR_proto_beta-like	27..236	CDD:349833	52/214 (24%)
		Cys-loop	152..166	CDD:349833	7/13 (54%)
LOC100494266	XP_002932551.2	LGIC_ECD	24..234	CDD:475126	58/229 (25%)
		LIC	43..434	CDD:455710	101/455 (22%)