Protein Alignment nAChRbeta1 and chrna7

DIOPT Version :10

• Sequence 1: NP_523927.2
• Gene: nAChRbeta1 / 38545
• FlyBaseID: FBgn0000038
• Length: 521
• Species: Drosophila melanogaster
• Sequence 2: XP_002937717.2
• Gene: chrna7 / 100493611
• XenbaseID: XB-GENE-990456
• Length: 504
• Species: Xenopus tropicalis
• Alignment Length: 518
• Identity: 192/518 - (37%)
• Similarity: 305/518 - (58%)
• Gaps: 37/518 - (7%)

  Fly     8 WLLCSILVLVAFSLVSASEDEERLVRDLFRGYNKLIRPVQNMTQKVGVRFGLAFVQLINVNEKNQ 72
            |::.::..:.| .:....|.:.:|.::|.:.||.|.|||.|.:..:.|.||::.:|:::|:||||
 Frog     9 WMIIAVCFMNA-KVSLQGEYQRKLYKELMKNYNPLERPVLNDSHPLTVYFGMSLMQIMDVDEKNQ 72

  Fly    73 IMKSNVWLRLVWYDYQLQWDEADYGGIGVLRLPPDKVWKPDIVLFNNADGNYEVRYKSNVLIYPT 137
            ::.:|:||::.|.||.|||:.::|.|:..:|.|..::|||||:|:|:||..::..:.:|||:..:
 Frog    73 VLTTNIWLQMQWIDYYLQWNMSEYPGVKNVRFPDGQIWKPDILLYNSADERFDASFHTNVLVNSS 137

  Fly   138 GEVLWVPPAIYQSSCTIDVTYFPFDQQTCIMKFGSWTFNGDQVSLALYNNKNFVDLSDYWKSGTW 202
            |...::||.|::|||.|||.:||||.|.|.:||||||:.|..:.|.:..:    |:|:|..:|.|
 Frog   138 GHCQYLPPGIFKSSCYIDVRWFPFDIQKCNLKFGSWTYGGWSLDLQMLES----DISEYISNGEW 198

  Fly   203 DIIEVPAYL--NVYEGDSNHPTETDITFYIIIRRKTLFYTVNLILPTVLISFLCVLVFYLPAEAG 265
            |::.||...  |.|| ....| ..|:||.||:||:||:|.:||::|.||||.|.:|||.|||::|
 Frog   199 DLVGVPGKRSENYYE-CCKEP-YLDVTFTIIMRRRTLYYGLNLLIPCVLISALALLVFLLPADSG 261

  Fly   266 EKVTLGISILLSLVVFLLLVSKILPPTSLVLPLIAKYLLFTFIMNTVSILVTVIIINWNFRGPRT 330
            ||::|||::||||.||:|||::|:|.||..:||||:|...|.|:..:|::||||::.::...|..
 Frog   262 EKISLGITVLLSLTVFMLLVAEIMPATSDSVPLIAQYFASTMIIVGLSVVVTVIVLQYHHHDPHG 326

  Fly   331 HRMPMYIRSIFLHYLPAFLFMKRPRKTRLRWMMEMPGMSMPAHPHPSYGSPAELPKHISAIGGKQ 395
            ..||.:.|.|.|::...||.||||.:.::|          |...|..... :.....::.:.|:|
 Frog   327 GNMPKWTRIILLNWCAWFLRMKRPGEDKVR----------PVCQHKERRC-SMTSVDVNTVSGQQ 380

  Fly   396 S---KMEVMELSDLHHPNCKINRKVNSGGELGLGDGCRRESESSDSILL--------SPEASKAT 449
            |   .|..:....|...:|      ....:.|:..|....|.:.|..||        .|:.||..
 Frog   381 SSNGNMLYIGFRGLEGIHC------TPTPDSGVICGRMTCSPTDDENLLHNVHHSEGDPDLSKIL 439

  Fly   450 EAVEFIAEHLRNEDLYIQTREDWKYVAMVIDRLQLYIFFIVTTAGTVGILMDAPHIFEYVDQD 512
            |.:.:||...|::|.......:||:.|.|:|||.|..|.:.|...|:||||.||:..|.|.:|
 Frog   440 EELRYIANRFRDQDDDESICNEWKFAASVVDRLCLMAFSVFTIICTIGILMSAPNFVEAVSKD 502

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRbeta1	NP_523927.2	LIC	8..500	CDD:455710	185/504 (37%)
		LGIC_ECD_nAChR_proto_beta-like	27..236	CDD:349833	86/210 (41%)
		Cys-loop	152..166	CDD:349833	9/13 (69%)
chrna7	XP_002937717.2	LIC	6..492	CDD:273305	187/506 (37%)