Protein Alignment nAChRbeta1 and chrna10

DIOPT Version :10

• Sequence 1: NP_523927.2
• Gene: nAChRbeta1 / 38545
• FlyBaseID: FBgn0000038
• Length: 521
• Species: Drosophila melanogaster
• Sequence 2: XP_031753261.1
• Gene: chrna10 / 100487976
• XenbaseID: XB-GENE-29077095
• Length: 501
• Species: Xenopus tropicalis
• Alignment Length: 491
• Identity: 170/491 - (34%)
• Similarity: 281/491 - (57%)
• Gaps: 41/491 - (8%)

  Fly    30 RLVRDLFRGYNKLIRPVQNMTQKVGVRFGLAFVQLINVNEKNQIMKSNVWLRLVWYDYQLQWDEA 94
            :|:.|||..|:..:|||::|.:.:.|...:...|:|:::|:|||:.:.:|:|.||:|..|:|::.
 Frog    27 KLMNDLFANYSNALRPVEDMDKAMNVTLQVTLSQIIDMDERNQILMAYLWIRQVWFDAYLRWNKE 91

  Fly    95 DYGGIGVLRLPPDKVWKPDIVLFNNADGNYEVRYKSNVLIYPTGEVLWVPPAIYQSSCTIDVTYF 159
            ||.|:..:|:|...||:|||||:||||..:....::||:|...|:::|..|||.:|||.:||::|
 Frog    92 DYDGLDTIRIPSSYVWRPDIVLYNNADDQFTGSMETNVVIRYDGQIMWDSPAITKSSCKVDVSFF 156

  Fly   160 PFDQQTCIMKFGSWTFNGDQVSLALYNNKNFVDLSDYWKSGTWDIIEVPAYLNVYE-GDSNHPTE 223
            |||.|.|.:.|||||:||:|:.  :.|:.:..||:|:.::..|:|:.:||..:|.. |..:.| .
 Frog   157 PFDGQQCRLTFGSWTYNGNQID--ILNHLDTGDLTDFVENVEWEILGMPAKKSVITYGCCSEP-Y 218

  Fly   224 TDITFYIIIRRKTLFYTVNLILPTVLISFLCVLVFYLPAEAGEKVTLGISILLSLVVFLLLVSKI 288
            .|:|:.:|::|:..||..||:||.|:||||..|.|||||::||||:||:::||:|.||.|||::.
 Frog   219 PDVTYTLILKRRASFYIFNLLLPCVMISFLAPLGFYLPADSGEKVSLGVTVLLALTVFQLLVAES 283

  Fly   289 LPPTSLVLPLIAKYLLFTFIMNTVSILVTVIIINWNFRGPRTHRMPMYIRSIFLHYLPAFLFM-- 351
            :||:..| |||.||.:.|..|.|.|..:|:.|:|.:..||....:|.:.:...|.|:....|:
 Frog   284 MPPSENV-PLIGKYYIATMTMITASTALTIFIMNIHHCGPEAKPVPQWAKKFILQYMSRIFFVYE 347

  Fly   352 -----KRPR---KTRLRWMMEMPGMSMPAHPHPSYGSPAELPKHISAIGGKQSKMEVMELSDLHH 408
                 :|||   :.......::||:...|..........:.|:.:|. ..|::| |.:|.|...|
 Frog   348 VGESCRRPRTEPEPNSERTSKVPGIDGQAKREDIADVVKDCPEKLSP-KDKEAK-EELEHSKYAH 410

  Fly   409 PNCKINRKVNSGGELGLGDG----------CRRESESSDSILLSPEASKATEAVEFIAEHLRNED 463
            ........|:..|.:|.|.|          |..|              :..:.:|:||...|::.
 Frog   411 SQESGKYYVSEQGGVGKGFGYEECPKIHCLCHNE--------------RLLKNIEYIANCFRDQR 461

  Fly   464 LYIQTREDWKYVAMVIDRLQLYIFFIVTTAGTVGIL 499
            ...:...:||.||.|:||..:::|||:....:|.|:
 Frog   462 ATQKRTGEWKKVAKVMDRFFMWVFFIMVFLMSVLIM 497

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRbeta1	NP_523927.2	LIC	8..500	CDD:455710	170/491 (35%)
		LGIC_ECD_nAChR_proto_beta-like	27..236	CDD:349833	81/206 (39%)
		Cys-loop	152..166	CDD:349833	8/13 (62%)
chrna10	XP_031753261.1	LIC	27..496	CDD:455710	169/488 (35%)
		LGIC_ECD_nAChR_A10	50..230	CDD:349824	71/182 (39%)
		Cys-loop	149..163	CDD:349824	8/13 (62%)