Protein Alignment nAChRbeta1 and chrnb3

DIOPT Version :10

• Sequence 1: NP_523927.2
• Gene: nAChRbeta1 / 38545
• FlyBaseID: FBgn0000038
• Length: 521
• Species: Drosophila melanogaster
• Sequence 2: XP_002942943.1
• Gene: chrnb3 / 100379831
• XenbaseID: XB-GENE-5793509
• Length: 460
• Species: Xenopus tropicalis
• Alignment Length: 482
• Identity: 188/482 - (39%)
• Similarity: 276/482 - (57%)
• Gaps: 62/482 - (12%)

  Fly    25 SEDEERLVRDLFRGYNKLIRPVQNMTQKVGVRFGLAFVQLINVNEKNQIMKSNVWLRLVWYDYQL 89
            :|.|:.|:|.||.||.|.:|||.|....:.|.|||...||::|:||.|:|.:|||||..|.|.:|
 Frog    28 AEIEDALLRKLFAGYQKWVRPVLNPNSTIKVNFGLKISQLVDVDEKKQLMTTNVWLRQEWMDMKL 92

  Fly    90 QWDEADYGGIGVLRLPPDKVWKPDIVLFNNADGNYEVRYKSNVLIYPTGEVLWVPPAIYQSSCTI 154
            :|:..|||||..:|:|.:.:|.||||||.||||.:|....:..:|...|.|.|.|||.|:||||:
 Frog    93 RWNPKDYGGITYIRVPSESLWLPDIVLFENADGRFEGSLMTKAIIKYDGTVTWTPPASYKSSCTM 157

  Fly   155 DVTYFPFDQQTCIMKFGSWTFNGDQVSLALYNNKNFVDLSDYWKSGTWDIIEVPAYLNV-YEGDS 218
            |||:||||:|.|.|||||||::|:.|.|.|.:..  ||..|::.:|.|||:.......: .:|..
 Frog   158 DVTFFPFDRQNCSMKFGSWTYDGNMVDLILLDEN--VDRKDFFDNGEWDILNATGLKGMRKDGLY 220

  Fly   219 NHPTETDITFYIIIRRKTLFYTVNLILPTVLISFLCVLVFYLPAEAGEKVTLGISILLSLVVFLL 283
            ::|.   ||:..::||..||||:.||:|.:.:|||.|||||||::.|||::|..|:|:||.||||
 Frog   221 SYPF---ITYSFVLRRLPLFYTLFLIIPCLGLSFLTVLVFYLPSDEGEKLSLSTSVLVSLTVFLL 282

  Fly   284 LVSKILPPTSLVLPLIAKYLLFTFIMNTVSILVTVIIINWNFRGPRT-HRMPMYIRSIFLHYLPA 347
            ::.:|:|.:|.|:|||.:||||..|..|:||:|||.:||.:.|...| |.|..:::.:||..||.
 Frog   283 VIEEIIPSSSKVIPLIGEYLLFIMIFVTLSIIVTVFVINVHHRSSATYHPMAPWVKRLFLEKLPK 347

  Fly   348 FLFMKRPRKTRLRWMMEMPGMSMPAHPHPSYGSPAELPKHISAIGGKQSKMEVMELSDLHHPNCK 412
            .|.||                     .|....|..:....:|:...|.|
 Frog   348 LLCMK---------------------GHVDRFSFFDSESDVSSAKSKPS---------------- 375

  Fly   413 INRKVNSGGELGLGDGCRRESESSD--SILLSPEASKATEAVEFIAEHLRNEDLYIQTREDWKYV 475
                           |.|:...:||  .:|:: ...||.:::::|:.|::.|....|..:|||:|
 Frog   376 ---------------GKRKNIHASDGEKVLIA-FLEKAADSIKYISTHVKKEHFIRQVVQDWKFV 424

  Fly   476 AMVIDRLQLYIFFIVTTAGTVGILMDA 502
            |.|:||:.|::|..|:..|:|.|...|
 Frog   425 AQVLDRIFLWLFLSVSITGSVLIFTPA 451

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRbeta1	NP_523927.2	LIC	8..500	CDD:455710	187/478 (39%)
		LGIC_ECD_nAChR_proto_beta-like	27..236	CDD:349833	96/209 (46%)
		Cys-loop	152..166	CDD:349833	10/13 (77%)
chrnb3	XP_002942943.1	LIC	2..451	CDD:455710	187/480 (39%)
		LGIC_ECD_nAChR_B3	56..234	CDD:349827	83/182 (46%)
		Cys-loop	155..169	CDD:349827	10/13 (77%)