Protein Alignment nAChRbeta1 and chrna5

DIOPT Version :9

• Sequence 1: NP_523927.2
• Gene: nAChRbeta1 / 38545
• FlyBaseID: FBgn0000038
• Length: 521
• Species: Drosophila melanogaster
• Sequence 2: XP_002937929.1
• Gene: chrna5 / 100379824
• XenbaseID: XB-GENE-5755296
• Length: 476
• Species: Xenopus tropicalis
• Alignment Length: 542
• Identity: 192/542 - (35%)
• Similarity: 284/542 - (52%)
• Gaps: 118/542 - (21%)

  Fly     5 CKSWLLCSILVLVAF---------SLVSASEDEERLVRDLF--RGYNKLIRPVQNMTQKVGVRFG 58
            |..:||...|.|...         |.::.|||  ||.:.||  :.|.:.:|||:::...|.|:||
 Frog    19 CAEYLLWLFLCLDILHGACGISEPSYIAKSED--RLFKYLFQQQDYQRWVRPVEHLNDTVKVKFG 81

  Fly    59 LAFVQLINVNEKNQIMKSNVWLRLVWYDYQLQWDEADYGGIGVLRLPPDKVWKPDIVLFNNADGN 123
            ||..||::|:||||:|.:||||:..|.|.:|:||..::.||..:|:|.|.:|.|||||::||||.
 Frog    82 LAITQLVDVDEKNQLMTTNVWLKQEWVDVKLRWDPNEFAGITSIRVPSDSIWIPDIVLYDNADGR 146

  Fly   124 YEVRYKSNVLIYPTGEVLWVPPAIYQSSCTIDVTYFPFDQQTCIMKFGSWTFNGDQVSLAL--YN 186
            :|......|:.| .|.:.|.|||.|:||||||||:||||.|.|.|||||||::|.||.:.|  |:
 Frog   147 FEGSVTKAVVRY-DGTINWTPPANYKSSCTIDVTFFPFDLQNCSMKFGSWTYDGSQVDIILEDYH 210

  Fly   187 NKNFVDLSDYWKSGTWDIIEVPAYLNVYEGDSNHPTETD-------ITFYIIIRRKTLFYTVNLI 244
                ||..|::.:|.|:|:         ....|....||       ||:..||:|..||||:.||
 Frog   211 ----VDKRDFFDNGEWEIV---------NATGNKGNRTDGCCFYPYITYSFIIKRLPLFYTLFLI 262

  Fly   245 LPTVLISFLCVLVFYLPAEAGEKVTLGISILLSLVVFLLLVSKILPPTSLVLPLIAKYLLFTFIM 309
            :|.:.:|||.:||||||:..|||::|..|:|:||.||||::.:|:|.:|.|:|||.:||:||.|.
 Frog   263 IPCIGLSFLTILVFYLPSNEGEKISLCTSVLVSLTVFLLVIEEIIPSSSKVIPLIGEYLVFTMIF 327

  Fly   310 NTVSILVTVIIINWNFRGPRTHR-MPMYIRSIFLHYLPAFLFMKRPRKTRLRWMMEMPGMSMPAH 373
            .|:||::||..||.:.|...||. |..::|.||||.||..|.|:
 Frog   328 VTLSIVLTVFAINIHNRSSATHNAMAPWVRKIFLHKLPKLLCMR--------------------- 371

  Fly   374 PHPSYGSPAELPKHISAIGGKQSKMEVMELSDLHHPNCKINRKVNSGGELGLGDGCRRESESSDS 438
                                             .|.:....||..:|...|
 Frog   372 ---------------------------------SHVDRYFTRKDETGKVRG-------------- 389

  Fly   439 ILLSPEASK-----ATEAVEFIAEHLRNEDLYIQTREDWKYVAMVIDRLQLYIFFIVTTAGTVGI 498
                ||:|:     |.:::.:|..|:..|....:..||||:||.|:||:.|:.|.:|:..|::.:
 Frog   390 ----PESSRNTLEAALDSIRYITRHVMKEHEVQEVVEDWKFVAQVLDRMFLWTFLLVSVIGSLFL 450

  Fly   499 LMDAPHIFEYVDQDRIIEIYRG 520
            .:...|.:..:    |:.::.|
 Frog   451 FIPVIHKWANI----IVPVHIG 468

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRbeta1	NP_523927.2	LIC	8..500	CDD:273305	188/517 (36%)
		Neur_chan_LBD	28..236	CDD:280998	95/218 (44%)
		Neur_chan_memb	243..498	CDD:280999	81/260 (31%)
chrna5	XP_002937929.1	LIC	19..453	CDD:273305	189/521 (36%)
		LGIC_ECD_nAChR_A5	47..255	CDD:349819	98/223 (44%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D188416at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.010