Protein Alignment nAChRbeta1 and chrna1

DIOPT Version :10

• Sequence 1: NP_523927.2
• Gene: nAChRbeta1 / 38545
• FlyBaseID: FBgn0000038
• Length: 521
• Species: Drosophila melanogaster
• Sequence 2: XP_002934647.1
• Gene: chrna1 / 100145177
• XenbaseID: XB-GENE-977139
• Length: 457
• Species: Xenopus tropicalis
• Alignment Length: 518
• Identity: 196/518 - (37%)
• Similarity: 299/518 - (57%)
• Gaps: 84/518 - (16%)

  Fly    13 ILVLVAFSLVSASEDEERLVRDLFRGYNKLIRPVQNMTQKVGVRFGLAFVQLINVNEKNQIMKSN 77
            |.:.:|.:||.:||||.||:.|||:.|||::|||:....||.|..||..:|||||:|.|||:.:|
 Frog     9 IFLFIAATLVFSSEDESRLINDLFKSYNKVVRPVKAFKDKVVVTLGLQLIQLINVDEVNQIVTTN 73

  Fly    78 VWLRLVWYDYQLQWDEADYGGIGVLRLPPDKVWKPDIVLFNNADGNYEVRYKSNVLIYPTGEVLW 142
            |.|:..|.|..|:|:..|||||..:|:....:|:|||||:|||||::.:..::.||:..||:::|
 Frog    74 VRLKQQWEDVHLKWNPEDYGGIKKVRISSGDIWRPDIVLYNNADGDFAIVQETKVLLDYTGKIIW 138

  Fly   143 VPPAIYQSSCTIDVTYFPFDQQTCIMKFGSWTFNGDQVSLALYN-NKNFVDLSDYWKSGTWDIIE 206
            .||||::|.|.:.|||||||.|.|.||.|:||::|   ||.:.| ..:..|||::.:||.|
 Frog   139 TPPAIFKSYCEMIVTYFPFDLQNCSMKLGTWTYDG---SLVVINPESDRPDLSNFMESGEW---- 196

  Fly   207 VPAYLNVYEG-------DSNHPTE-TDITFYIIIRRKTLFYTVNLILPTVLISFLCVLVFYLPAE 263
               |:..|.|       |....|. .|||::.:::|..|::.||:::|.:|.|||..||||||.:
 Frog   197 ---YMKDYRGWKHWVYYDCCPETPYLDITYHFLLQRLPLYFIVNVVIPCLLFSFLTGLVFYLPTD 258

  Fly   264 AGEKVTLGISILLSLVVFLLLVSKILPPTSLVLPLIAKYLLFTFIMNTVSILVTVIIINWNFRGP 328
            :|||:||.:|:|||||||||::.:::|.||..:|||.||:|||.:....||::|||:||.:.|.|
 Frog   259 SGEKITLSVSVLLSLVVFLLVIVELIPSTSSAVPLIGKYMLFTMVFVITSIVITVIVINTHHRSP 323

  Fly   329 RTHRMPMYIRSIFLHYLPAFLF---MKRPRKTRLRWMMEMPGMSMPAHPHPSYGSPAELPKHISA 390
            .||.||.:::.||:..:|..:|   ||||.:.:.:
 Frog   324 STHIMPQWLKKIFIETIPRVMFFSTMKRPAQDQQK------------------------------ 358

  Fly   391 IGGKQSKMEVMELSDLHHPNCKINRKVNSGGELGLGDGCRRESESSDSILLSPEASKATEAVEFI 455
               |:...|.:::||:             .|:||     ....:....||.:|:...|.|..::|
 Frog   359 ---KKIFTEDIDISDI-------------SGKLG-----PAAVKYQSPILKNPDVKSAIEGAKYI 402

  Fly   456 AEHLRNEDLYIQTREDWKYVAMVIDRLQLYIFFIVTTAGTVGILMDAPHIFEYVDQDRIIEIY 518
            ||.::::....:..|:||:||||:|.|.|.:|.||...||:.|.           ..|:||::
 Frog   403 AETMKSDQESNKASEEWKFVAMVLDHLLLAVFMIVCIIGTLAIF-----------AGRLIELH 454

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRbeta1	NP_523927.2	LIC	8..500	CDD:455710	193/498 (39%)
		LGIC_ECD_nAChR_proto_beta-like	27..236	CDD:349833	95/217 (44%)
		Cys-loop	152..166	CDD:349833	9/13 (69%)
chrna1	XP_002934647.1	LIC	21..447	CDD:455710	189/497 (38%)
		LGIC_ECD_nAChR_A1	22..231	CDD:349815	96/218 (44%)
		Cys-loop	148..162	CDD:349815	9/13 (69%)