Protein Alignment nAChRbeta1 and chrng

DIOPT Version :10

• Sequence 1: NP_523927.2
• Gene: nAChRbeta1 / 38545
• FlyBaseID: FBgn0000038
• Length: 521
• Species: Drosophila melanogaster
• Sequence 2: NP_001096503.1
• Gene: chrng / 100125132
• XenbaseID: XB-GENE-990010
• Length: 510
• Species: Xenopus tropicalis
• Alignment Length: 520
• Identity: 176/520 - (33%)
• Similarity: 271/520 - (52%)
• Gaps: 70/520 - (13%)

  Fly    13 ILVLVAFSLVSASEDEERLVRDLFRGYNKLIRPVQNMTQKVGVRFGLAFVQLINVNEKNQIMKSN 77
            :|||:..|......:||.|:.||.:.|||.:||.:.....|.|...|....||::||:.:.:.:|
 Frog     6 LLVLICISAALCHNEEEGLLNDLMKNYNKNLRPAEKDGDIVSVSIKLTLTNLISLNEREEALTTN 70

  Fly    78 VWLRLVWYDYQLQWDEADYGGIGVLRLPPDKVWKPDIVLFNNADGNYEVRYKSNVLIYPTGEVLW 142
            ||:.:.|.||:|.||..:|.||.::|:|...||.||:.|.||.||.:::...:|.|:...|.:.|
 Frog    71 VWVEVQWRDYRLSWDPNEYYGISMMRIPSTSVWLPDVGLENNVDGTFDIALYANTLVSSDGSMYW 135

  Fly   143 VPPAIYQSSCTIDVTYFPFDQQTCIMKFGSWTFNGDQVSLALYNNKNF-----VDLSDYWKSGTW 202
            :|||||:|||.:.|||||||.|.|.|.|.|.|::.:::.|.|..::..     :|...:.::|.|
 Frog   136 LPPAIYRSSCPVVVTYFPFDWQNCSMVFQSQTYSANEIELLLTVDEQTIEWIEIDPEAFTENGEW 200

  Fly   203 DIIEVPAYLNVYEGDSNHPTETD------ITFYIIIRRKTLFYTVNLILPTVLISFLCVLVFYLP 261
            .|..:||...:     ||....|      |.||:||:||.|||.:|:|:|.|||||:.:||::||
 Frog   201 AIKHMPAKKII-----NHRLTPDDLNYQQIVFYLIIQRKPLFYIINIIVPCVLISFVSILVYFLP 260

  Fly   262 AEA-GEKVTLGISILLSLVVFLLLVSKILPPTSLVLPLIAKYLLFTFIMNTVSILVTVIIINWNF 325
            |:| |:|.|:.|:|||:..|||.|:::.:|.||..:|||.|||.|..::....:...||::|.:.
 Frog   261 AKAGGQKCTVSINILLAQTVFLFLIAQKIPETSTAVPLIVKYLTFLMVVTITIVANAVIVLNISL 325

  Fly   326 RGPRTHRMPMYIRSIFLHYLPAFLFMKRPRKTRLRWMMEMPGMSMPAHPHPSYGSP--AELPKHI 388
            |.|.||.|...:|.:.|..:|..|.|                     |..||..:|  |.|.:..
 Frog   326 RTPNTHSMSSTVRELCLRTVPRLLRM---------------------HLRPSDAAPPLAPLMRRS 369

  Fly   389 SAIGGKQSKMEVMELSDLHHPNCKI---NRKVNSG------GELGLGDGCRRESESSDSILLS-- 442
            |::|......|.|    |..|..::   .:|...|      .::|.|    .|:.:||.::.|
 Frog   370 SSVGLMIKADEYM----LRKPRSQLMFEKQKERDGLMKVVLDKIGRG----MENNTSDDLVHSLK 426

  Fly   443 ---PEASKATEAVEFIAEHLRNEDLYIQTREDWKYVAMVIDR----LQLYIFFIVTTAGTVGILM 500
               ||.....||...||...|.::.:....|:|..:..||||    :..::||:    ||:|..:
 Frog   427 HAAPEIRACVEACCHIASATREKNEFKSENEEWILIGRVIDRVCFLVMCFLFFL----GTIGTFL 487

  Fly   501  500
             Frog   488  487

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRbeta1	NP_523927.2	LIC	8..500	CDD:455710	176/518 (34%)
		LGIC_ECD_nAChR_proto_beta-like	27..236	CDD:349833	82/219 (37%)
		Cys-loop	152..166	CDD:349833	9/13 (69%)
chrng	NP_001096503.1	LGIC_ECD_nAChR_G	44..235	CDD:349830	72/195 (37%)
		Cys-loop	145..159	CDD:349830	9/13 (69%)
		Neur_chan_memb	242..486	CDD:460753	85/276 (31%)