Protein Alignment nAChRbeta1 and chrnb1

DIOPT Version :10

• Sequence 1: NP_523927.2
• Gene: nAChRbeta1 / 38545
• FlyBaseID: FBgn0000038
• Length: 521
• Species: Drosophila melanogaster
• Sequence 2: NP_001240739.1
• Gene: chrnb1 / 100006941
• ZFINID: ZDB-GENE-070821-4
• Length: 492
• Species: Danio rerio
• Alignment Length: 518
• Identity: 195/518 - (37%)
• Similarity: 292/518 - (56%)
• Gaps: 61/518 - (11%)

  Fly     6 KSWLLCSILVLVAFSLVSASEDEERLVRDLFRGYNKLIRPVQNMTQKVGVRFGLAFVQLINVNEK 70
            :.|::.:..:....::..|:|.|::|::.||..||..:||.:|..::|.||.|:.....:::|.|
Zfish     4 QDWIIITCCLCGLGAMTGATEMEDKLMKKLFSAYNSKVRPARNPEERVVVRIGMILSSFVSLNMK 68

  Fly    71 NQIMKSNVWLRLVWYDYQLQWDEADYGGIGVLRLPPDKVWKPDIVLFNNADGNYEVRYKSNVLIY 135
            ::.|.:.|.:.|.|.||:|.|:..||||:.|||:...|||.|||||.||.||.:.|..:.:|..|
Zfish    69 DEEMNTIVMMNLEWNDYRLSWNPKDYGGVDVLRISSGKVWLPDIVLINNNDGVFGVALQVHVQAY 133

  Fly   136 PTGEVLWVPPAIYQSSCTIDVTYFPFDQQTCIMKFGSWTFNGDQVSLALYNNKNFVDLSD----- 195
            ..|.|.|.|||:|:|||.:.|||||||.|.|.|.|.|:|::..:|.|....:|...::.:
Zfish   134 SNGRVTWTPPALYKSSCGVKVTYFPFDWQNCTMVFRSYTYDSSEVDLQHALDKRGKEIKEIILDT 198

  Fly   196 -YWKSGTWDIIEVPAYLNV----YEGDSNHPTETDITFYIIIRRKTLFYTVNLILPTVLISFLCV 255
             :.:||.|.|....:..||    ||         |||||:||.||.:||.||::||.:||:.:.:
Zfish   199 GFSESGEWHIRHKVSRKNVREDLYE---------DITFYLIIERKPMFYVVNIVLPCILITIIAI 254

  Fly   256 LVFYLPAEAGEKVTLGISILLSLVVFLLLVSKILPPTSLVLPLIAKYLLFTFIMNTVSILVTVII 320
            ..||||.:||||:.|.|::||:|.|||||::..:|.|||.:|:|..||:.|.|:.|.|::::|::
Zfish   255 FNFYLPPDAGEKMGLSINVLLTLTVFLLLLANKIPETSLGVPIIVNYLMITMILVTFSVILSVVV 319

  Fly   321 INWNFRGPRTHRMPMYIRSIFLHYLPAFLFMKRPRKTRLRWMMEMPGMSMPAHPHPSYGSPAELP 385
            :|.:.|.|.||:||:::|.||:|.||.:|.|.|| |......:|.|...
Zfish   320 LNLHHRSPNTHQMPLWVRKIFIHMLPPYLGMLRP-KVETPLFLEKPAKK---------------- 367

  Fly   386 KHISAIGGKQSKMEVMELSDL---------HHPN--CKINRKVNSGGELGLGDGCRRESESSDSI 439
            ::|.||.....:..:.:.|::         :.|:  |...||...|              .|..:
Zfish   368 ENIQAINRVADEYFIRKPSNMNFLFPKPHRYQPDGQCTDLRKFIDG--------------PSHYL 418

  Fly   440 LLSPEASKATEAVEFIAEHLRNEDLYIQTREDWKYVAMVIDRLQLYIFFIVTTAGTVGILMDA 502
            .|.||...|.||:.:|||.|:.|..|...:|||:|||||.|||.|:||.|.||.||:||..||
Zfish   419 TLPPELKTAVEAITYIAEQLQAEKDYEALKEDWQYVAMVADRLFLWIFVIFTTLGTLGIFTDA 481

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRbeta1	NP_523927.2	LIC	8..500	CDD:455710	193/512 (38%)
		LGIC_ECD_nAChR_proto_beta-like	27..236	CDD:349833	87/218 (40%)
		Cys-loop	152..166	CDD:349833	9/13 (69%)
chrnb1	NP_001240739.1	LGIC_ECD	26..235	CDD:475126	87/217 (40%)
		Neur_chan_memb	242..478	CDD:460753	97/266 (36%)