Protein Alignment nAChRbeta1 and chrnb1l

DIOPT Version :9

• Sequence 1: NP_523927.2
• Gene: nAChRbeta1 / 38545
• FlyBaseID: FBgn0000038
• Length: 521
• Species: Drosophila melanogaster
• Sequence 2: NP_001233249.1
• Gene: chrnb1l / 100005295
• ZFINID: ZDB-GENE-060811-1
• Length: 486
• Species: Danio rerio
• Alignment Length: 519
• Identity: 197/519 - (37%)
• Similarity: 295/519 - (56%)
• Gaps: 82/519 - (15%)

  Fly    24 ASEDEERLVRDLFRGYNKLIRPVQNMTQKVGVRFGLAFVQLINVNEKNQIMKSNVWLRLVWYDYQ 88
            |||.|.||:.|||:.||..:||.:...::|.||.|:..||||::|:||..|.:||::.:.|.||:
Zfish    16 ASEAERRLLEDLFQDYNLKVRPARTWNERVMVRVGMTLVQLISLNQKNGEMTTNVFMNMEWTDYR 80

  Fly    89 LQWDEADYGGIGVLRLPPDKVWKPDIVLFNNADGNYEVRYKSNVLIYPTGEVLWVPPAIYQSSCT 153
            |.|:..||..|.|:|:||.|||:|||.|.||.||.::|....|||:...|.|.|:|||||:|||:
Zfish    81 LSWNPEDYDKIDVVRIPPVKVWRPDIYLINNNDGQFDVALYVNVLVRSDGTVSWLPPAIYRSSCS 145

  Fly   154 IDVTYFPFDQQTCIMKFGSWTFNGDQVSL--ALYNNKN-----FVDLSDYWKSGTWDIIEVPAYL 211
            |:|.|||||.|.|.|.|.|:|::..:|.|  .|..:.|     .:|.:.:.::|.|.|...|:..
Zfish   146 IEVAYFPFDWQNCSMVFRSYTYDSSEVDLQYGLDEDGNELHEIVIDENAFTENGEWQICHKPSRK 210

  Fly   212 NV----YEGDSNHPTETDITFYIIIRRKTLFYTVNLILPTVLISFLCVLVFYLPAEAGEKVTLGI 272
            ||    ||         |||||:||.||.|||.:|:|:|.:|.|.|.:.|||||..||||:||.|
Zfish   211 NVQDDLYE---------DITFYLIIERKPLFYVINIIVPCILTSVLAIFVFYLPPGAGEKMTLSI 266

  Fly   273 SILLSLVVFLLLVSKILPPTSLVLPLIAKYLLFTFIMNTVSILVTVIIINWNFRGPRTHRMPMYI 337
            |:|::|.||:||::..:|.|||.:|:|..|::||.|:.|.|::::|:::|.:.|.|.||.||.::
Zfish   267 SVLIALTVFMLLLADKVPETSLAIPIIVNYVMFTMILVTFSVILSVVVLNLHHRTPSTHHMPGWV 331

  Fly   338 RSIFLHYLPAFLFMKRPRKTRLRWMMEMPGMSMPAHPHPSYGSPAELPKHISAIGGKQSKMEVME 402
            |.:|::.||.:|.:.||               .|..|      ..|.||....:|
Zfish   332 RKVFINLLPRYLGVLRP---------------TPEEP------VEEEPKENVPMG---------- 365

  Fly   403 LSDLHHPNCKINRKVNSGGELGLGD----------GCRRES-------ESSDS--ILLSPEASKA 448
                    | :...:..|||..:..          |...||       .:||:  ::|.|....|
Zfish   366 --------C-LGNSLRPGGEYFIRKINPELVMPWRGSHNESTVKLQRFSNSDNYCLILPPNLKSA 421

  Fly   449 TEAVEFIAEHLRNEDLYIQTREDWKYVAMVIDRLQLYIFFIVTTAGTVGILMDAPHIFEYV-DQ 511
            ..|:.:::|.|:.:|:.....:||:|:|:|:|||.|::|.::||.||:.:.:||.  |.|. ||
Zfish   422 IAAITYMSEQLKKQDVDDTMTDDWQYIAVVLDRLFLWLFVVITTLGTLTMFLDAS--FNYTPDQ 483

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRbeta1	NP_523927.2	LIC	8..500	CDD:273305	191/505 (38%)
		Neur_chan_LBD	28..236	CDD:280998	96/218 (44%)
		Neur_chan_memb	243..498	CDD:280999	87/273 (32%)
chrnb1l	NP_001233249.1	LIC	11..473	CDD:273305	191/505 (38%)
		Neur_chan_LBD	20..230	CDD:280998	96/218 (44%)
		Neur_chan_memb	237..472	CDD:280999	87/274 (32%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.910