DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Syx17 and Stx17

DIOPT Version :9

Sequence 1:	NP_001261414.1	Gene:	Syx17 / 38541	FlyBaseID:	FBgn0035540	Length:	346	Species:	Drosophila melanogaster
Sequence 2:	NP_080619.2	Gene:	Stx17 / 67727	MGIID:	1914977	Length:	301	Species:	Mus musculus

Alignment Length:	306	Identity:	96/306 - (31%)
Similarity:	156/306 - (50%)	Gaps:	27/306 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 DEKLPLKQAEVSIQRFQDVAVPHHLSLLKNHRSNIEKSLALGDWQKIKKEELNAMRVIKQIKNLL 68
            :||:.|::.|.:||:|..:.:|..|..|:.|:.||||......|.|:.:|.:||.|.::|:::.:
Mouse     5 EEKVKLRRLEPAIQKFTKIVIPTDLERLRKHQINIEKYQRCRIWDKLHEEHINAGRTVQQLRSNI 69

  Fly    69 LEMDALREKVREEDLERFDDLMKPGRDTAFAGMKEFAELQLKS---------------PTSTLSS 118
            .||:.|..||.::||.....::.|.::.|.....||.:|.|:|               |:.|.|:
Mouse    70 REMEKLCLKVHKDDLVLLKRMIDPVKEAAATATAEFLQLHLESVEELKKQVNDEELLQPSLTRST 134

  Fly   119 QYDDDLDNQPQEVDMNSLPAHRHMPQLQLNFQLEEHQLAQRQACLDQMENLQQEIYDLHGMFQGM 183
            ..|..|.....|....||.....:|           ::.|.|...:..|.|:.::.:|..:...|
Mouse   135 TVDGVLHTGEAEAASQSLTQIYALP-----------EIPQDQNAAESWETLEADLIELSHLVTDM 188

  Fly   184 RQLTAEQSVAVEKIADNAEEALENVQQGELNLRRALTYKKAMYPVVGALLGTCVGGPIGLVAGMK 248
            ..|.:.|...::.|||:...|..||::|..||::|..||.|..||.|||:|..|||||||:||.|
Mouse   189 SLLVSSQQEKIDSIADHVNSAAVNVEEGTKNLQKAAKYKLAALPVAGALIGGVVGGPIGLLAGFK 253

  Fly   249 AGGL-AAVGCGILGFTGGSVLKANPNVMHGNIEEEQVEPDSESTER 293
            ..|: ||:|.|:||||||.:::.....|...:.....:..|:|.::
Mouse   254 VAGIAAALGGGVLGFTGGKLIQRRKQKMMEKLTSSCPDLPSQSDKK 299

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Syx17	NP_001261414.1	SNARE_syntaxin17	156..217	CDD:277199	17/60 (28%)
Stx17	NP_080619.2	SNARE_syntaxin17	161..222	CDD:277199	17/60 (28%)
		Necessary and sufficient for localization to autophagosome. /evidence=ECO:0000250\|UniProtKB:P56962	228..274		28/45 (62%)
		Endoplasmic reticulum retention signal. /evidence=ECO:0000255	298..301		0/2 (0%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167836258
Domainoid	1	1.000	157	1.000	Domainoid score	I4145
eggNOG	1	0.900	-	-		E1_COG5325
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H9917
Inparanoid	1	1.050	158	1.000	Inparanoid score	I4253
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG49838
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0008362
OrthoInspector	1	1.000	-	-		oto92702
orthoMCL	1	0.900	-	-		OOG6_108277
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5748
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	13	12.690