Protein Alignment Syx17 and STX17

DIOPT Version :10

• Sequence 1: NP_001261414.1
• Gene: Syx17 / 38541
• FlyBaseID: FBgn0035540
• Length: 346
• Species: Drosophila melanogaster
• Sequence 2: NP_060389.2
• Gene: STX17 / 55014
• HGNCID: 11432
• Length: 302
• Species: Homo sapiens
• Alignment Length: 281
• Identity: 95/281 - (33%)
• Similarity: 151/281 - (53%)
• Gaps: 12/281 - (4%)

  Fly     4 DEKLPLKQAEVSIQRFQDVAVPHHLSLLKNHRSNIEKSLALGDWQKIKKEELNAMRVIKQIKNLL 68
            :||:.|::.|.:||:|..:.:|..|..|:.|:.||||......|.|:.:|.:||.|.::|:::.:
Human     5 EEKVKLRRLEPAIQKFIKIVIPTDLERLRKHQINIEKYQRCRIWDKLHEEHINAGRTVQQLRSNI 69

  Fly    69 LEMDALREKVREEDLERFDDLMKPGRDTAFAGMKEFAELQLKSPTSTLSSQYDDD--LDNQPQEV 131
            .|::.|..|||::||.....::.|.::.|.|...||.:|.|:| ...|..|::|:  |...|...
Human    70 REIEKLCLKVRKDDLVLLKRMIDPVKEEASAATAEFLQLHLES-VEELKKQFNDEETLLQPPLTR 133

  Fly   132 DM------NSLPAHRHMPQLQLNFQLEEHQLAQRQACLDQMENLQQEIYDLHGMFQGMRQLTAEQ 190
            .|      ::..|......|...:.|.|  :.|.|...:..|.|:.::.:|..:......|...|
Human   134 SMTVGGAFHTTEAEASSQSLTQIYALPE--IPQDQNAAESWETLEADLIELSQLVTDFSLLVNSQ 196

  Fly   191 SVAVEKIADNAEEALENVQQGELNLRRALTYKKAMYPVVGALLGTCVGGPIGLVAGMKAGGL-AA 254
            ...::.|||:...|..||::|..||.:|..||.|..||.|||:|..|||||||:||.|..|: ||
Human   197 QEKIDSIADHVNSAAVNVEEGTKNLGKAAKYKLAALPVAGALIGGMVGGPIGLLAGFKVAGIAAA 261

  Fly   255 VGCGILGFTGGSVLKANPNVM 275
            :|.|:||||||.:::.....|
Human   262 LGGGVLGFTGGKLIQRKKQKM 282

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Syx17	NP_001261414.1	SNARE_syntaxin17	156..217	CDD:277199	16/60 (27%)
STX17	NP_060389.2	COG5325	2..228	CDD:227635	64/225 (28%)
		SNARE_syntaxin17	162..223	CDD:277199	16/60 (27%)
		Necessary and sufficient for localization to autophagosome. /evidence=ECO:0000269|PubMed:23217709	229..275		28/45 (62%)
		Endoplasmic reticulum retention signal. /evidence=ECO:0000255	299..302