DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Syx17 and Stx17

DIOPT Version :9

Sequence 1:	NP_001261414.1	Gene:	Syx17 / 38541	FlyBaseID:	FBgn0035540	Length:	346	Species:	Drosophila melanogaster
Sequence 2:	NP_663775.1	Gene:	Stx17 / 252853	RGDID:	708499	Length:	301	Species:	Rattus norvegicus

Alignment Length:	307	Identity:	95/307 - (30%)
Similarity:	156/307 - (50%)	Gaps:	29/307 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 DEKLPLKQAEVSIQRFQDVAVPHHLSLLKNHRSNIEKSLALGDWQKIKKEELNAMRVIKQIKNLL 68
            :||:.|::.|.:||:|..:.:|..|..||.|:.||||......|.|:.:|.:||.|.::|:::.:
  Rat     5 EEKVKLRRLEPAIQKFTKIVIPTDLERLKKHQINIEKYQRCRIWDKLHEEHINAGRTVQQLRSNI 69

  Fly    69 LEMDALREKVREEDLERFDDLMKPGRDTAFAGMKEFAELQLKS----------------PTSTLS 117
            .||:.|..||.::||.....::.|.::.|.|...||.:|.|:|                |:.|.|
  Rat    70 REMEKLCLKVHKDDLILLKRMIDPMKEAAAAATAEFLQLHLESVEELKKQVKNEEALLQPSLTRS 134

  Fly   118 SQYDDDLDNQPQEVDMNSLPAHRHMPQLQLNFQLEEHQLAQRQACLDQMENLQQEIYDLHGMFQG 182
            :.. |.:.....|....||.....:|           ::.:.|...:..|.|:.::.:|..:...
  Rat   135 TTI-DGVHTGEAEAASQSLTQIYALP-----------EIPRDQNAAESWETLEADLIELSHLVTD 187

  Fly   183 MRQLTAEQSVAVEKIADNAEEALENVQQGELNLRRALTYKKAMYPVVGALLGTCVGGPIGLVAGM 247
            |..|...|...::.|||:...|..||::|..||::|..||.|..||.||::|..|||||||:||.
  Rat   188 MSLLVNSQQEKIDSIADHVNSAAVNVEEGTKNLQKAAKYKLAALPVAGAVIGGVVGGPIGLLAGF 252

  Fly   248 KAGGL-AAVGCGILGFTGGSVLKANPNVMHGNIEEEQVEPDSESTER 293
            |..|: ||:|.|:||||||.:::.....|...:.....:..|:|.::
  Rat   253 KVAGIAAALGGGVLGFTGGKLIQRRKQKMMEKLTSSCPDLPSQSDKK 299

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Syx17	NP_001261414.1	SNARE_syntaxin17	156..217	CDD:277199	16/60 (27%)
Stx17	NP_663775.1	SNARE_syntaxin17	161..222	CDD:277199	16/60 (27%)
		Necessary and sufficient for localization to autophagosome. /evidence=ECO:0000250\|UniProtKB:P56962	228..274		27/45 (60%)
		Required for interaction with COPB1, TMED9 and TMED10. /evidence=ECO:0000269\|PubMed:21545355	273..301		3/27 (11%)
		Endoplasmic reticulum retention signal. /evidence=ECO:0000255	298..301		0/2 (0%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166339922
Domainoid	1	1.000	152	1.000	Domainoid score	I4242
eggNOG	1	0.900	-	-		E1_COG5325
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H9917
Inparanoid	1	1.050	152	1.000	Inparanoid score	I4268
OMA	1	1.010	-	-		QHG49838
OrthoDB	1	1.010	-	-		D1493840at2759
OrthoFinder	1	1.000	-	-		FOG0008362
OrthoInspector	1	1.000	-	-		oto96265
orthoMCL	1	0.900	-	-		OOG6_108277
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	14	13.670