Protein Alignment Syx17 and STX12

DIOPT Version :10

• Sequence 1: NP_001261414.1
• Gene: Syx17 / 38541
• FlyBaseID: FBgn0035540
• Length: 346
• Species: Drosophila melanogaster
• Sequence 2: NP_803173.1
• Gene: STX12 / 23673
• HGNCID: 11430
• Length: 276
• Species: Homo sapiens
• Alignment Length: 217
• Identity: 43/217 - (19%)
• Similarity: 90/217 - (41%)
• Gaps: 60/217 - (27%)

  Fly     7 LPLKQAEVSIQRFQDVAVPHHLSLLKNHRSNIEKSLALGDWQKIKKEELNAMRVIKQIKNLLLEM 71
            |||..:|...||.|...:.:..|...|:...:::.::     :.:||.:...|...::
Human    89 LPLSTSEQRQQRLQKERLMNDFSAALNNFQAVQRRVS-----EKEKESIARARAGSRL------- 141

  Fly    72 DALREKVREEDLERFDDLMKPGRDTAFAGMKEFAELQLKSPTSTLSSQYDDDLDNQPQEVDMNSL 136
             :..|:.|||.|..||            ..:|:.::|         || :|::....|::::
Human   142 -SAEERQREEQLVSFD------------SHEEWNQMQ---------SQ-EDEVAITEQDLEL--- 180

  Fly   137 PAHRHMPQLQLNFQLEEHQLAQRQACLDQMENLQQEIYDLHGMFQGMRQLTAEQSVAVEKIADNA 201
                          ::|.:.|.||        |:.:|.|::.:|:.:..:..:|...::.|..|.
Human   181 --------------IKERETAIRQ--------LEADILDVNQIFKDLAMMIHDQGDLIDSIEANV 223

  Fly   202 EEALENVQQGELNLRRALTYKK 223
            |.:..:|::....|:||..|:|
Human   224 ESSEVHVERATEQLQRAAYYQK 245

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Syx17	NP_001261414.1	SNARE_syntaxin17	156..217	CDD:277199	13/60 (22%)
STX12	NP_803173.1	Syntaxin_2	30..132	CDD:464199	11/47 (23%)
		SNARE_syntaxin12	181..247	CDD:277229	18/73 (25%)