DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Syx17 and TSNARE1

DIOPT Version :9

Sequence 1:	NP_001261414.1	Gene:	Syx17 / 38541	FlyBaseID:	FBgn0035540	Length:	346	Species:	Drosophila melanogaster
Sequence 2:	XP_011515216.1	Gene:	TSNARE1 / 203062	HGNCID:	26437	Length:	838	Species:	Homo sapiens

Alignment Length:	371	Identity:	65/371 - (17%)
Similarity:	112/371 - (30%)	Gaps:	145/371 - (39%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 TRDEKLPLKQAEVSIQRFQDVAVPHHLSLL---------KNHRSNIEKSLALGDWQKIKKEELNA 57
            ||......::.||.:||     |..|..||         :.||.          |.:| .:.:||
Human   525 TRKPNFSPQETEVLVQR-----VRRHYPLLFGALRGTPARKHRV----------WSRI-LQAVNA 573

  Fly    58 M----RVIKQIKNLLLEM-DALREKVRE------------------------------------- 80
            :    |.:..:|:...:: .|:|:|:.|
Human   574 LGYCRRDLGDLKHKWRDLRGAVRKKLAEGGPAPGLLLTPVERMVAETFSAHGPQGEGQTTEPLPT 638

  Fly    81 -EDLERFDDLMKPGRDTAFAGMKEFAELQLKS-------------------PTSTLSSQYDDDLD 125
             |:.|....|..|.|......:.|...|.|:.                   |.:||...:.   .
Human   639 DEEDETPSCLWLPLRSLEGPSLPEPDPLDLRGVFHAPTSSPSPPASPASTPPATTLMGAFQ---P 700

  Fly   126 NQPQEVDMNSLPAHRHMPQLQLNFQLEEHQLAQRQACLDQMENLQQEIYDLH--------GMFQG 182
            :.|.......||:.|                  ..|...:....:|::.|.|        ...|.
Human   701 SPPSSAPAPPLPSRR------------------TPAAASETSAFEQQLLDSHRQQGALLSSWAQQ 747

  Fly   183 MRQLTAEQSVAVEKIADNAEEALENVQQGELNLRRALTYKKAMYPVVGALLGTCVGGPIGLVAGM 247
            ...|.|:|::.::::|:.::...:.|:.....|.|.:..:.           |....| .|..|.
Human   748 QSTLMAQQNLLLQRLAEQSQRLADGVEALNRTLERLVEARP-----------TREASP-SLQDGS 800

  Fly   248 KAGGLAAVGCGILGFTGGSVLKANPNVMHGNIE---------EEQV 284
            .|.|:|.      |..|||  :.:|...|..:|         ||::
Human   801 PASGVAQ------GPAGGS--QDSPKGTHSGLEVFSGMILKVEEEI 838

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Syx17	NP_001261414.1	SNARE_syntaxin17	156..217	CDD:277199	11/68 (16%)
TSNARE1	XP_011515216.1	Myb_DNA-bind_5	151..225	CDD:290584
		Syntaxin_2	292..393	CDD:291208
		SNARE	444..>484	CDD:304603
		Myb_DNA-bind_5	526..598	CDD:290584	19/87 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5325
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900