Protein Alignment slow and SVEP1

DIOPT Version :10

• Sequence 1: NP_647898.3
• Gene: slow / 38540
• FlyBaseID: FBgn0035539
• Length: 512
• Species: Drosophila melanogaster
• Sequence 2: NP_699197.3
• Gene: SVEP1 / 79987
• HGNCID: 15985
• Length: 3571
• Species: Homo sapiens
• Alignment Length: 330
• Identity: 75/330 - (22%)
• Similarity: 109/330 - (33%)
• Gaps: 89/330 - (26%)

  Fly   125 MTNTFGPPPPPMPLSPRYGKGEDNTQDVEFIGVRERGRGYSFVPSVTVTTAPPPNL--NRRSASP 187
            :..|:.||......|| ...|:..:.:..|:    .|..|:|..::.....|...|  ||.....
Human  3223 LDGTWEPPFSDESCSP-VSCGKPESPEHGFV----VGSKYTFESTIIYQCEPGYELEGNRERVCQ 3282

  Fly   188 GSRSSIGTIPPLVPARRGYSYTTTTSSPPVNTITTDNPFETNTIG--------RGYPTD-PKEME 243
            .:|...|.:.         ....|....|:..:......|..|.|        |||..: |.|..
Human  3283 ENRQWSGGVA---------ICKETRCETPLEFLNGKADIENRTTGPNVVYSCNRGYSLEGPSEAH 3338

  Fly   244 RRHICMQQRTVTMPV----------------------KRTEVYSRPTWK---------HVATPCQ 277
                |.:..|.:.||                      |...|....:.|         |....|.
Human  3339 ----CTENGTWSHPVPLCKPNPCPVPFVIPENALLSEKEFYVDQNVSIKCREGFLLQGHGIITCN 3399

  Fly   278 PP---TFSGQKCTRVQV---VH-EQAYRDVIDHKTAQQMTYDCCTGWSRENPRSDSCMK------ 329
            |.   |.:..||.::..   .| |.|....:.::....:||.|.:|:..|......|::
Human  3400 PDETWTQTSAKCEKISCGPPAHVENAIARGVHYQYGDMITYSCYSGYMLEGFLRSVCLENGTWTS 3464

  Fly   330 -PICSA----RCQNGGNCTAPSTCSCPTGFTGRFCEQDVDECQTEKPCDQQCIN---THGSYFCR 386
             |||.|    .|||||.|..|:.||||.|:.||.||:.:        |...|:|   ....|.|.
Human  3465 PPICRAVCRFPCQNGGICQRPNACSCPEGWMGRLCEEPI--------CILPCLNGGRCVAPYQCD 3521

  Fly   387 CRQGF 391
            |..|:
Human  3522 CPPGW 3526

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
slow	NP_647898.3	EMI	245..319	CDD:462204	20/111 (18%)
		EGF_CA	<336..360	CDD:238011	14/23 (61%)
		EGF_CA	362..401	CDD:214542	7/33 (21%)
SVEP1	NP_699197.3	VWA	83..258	CDD:459670
		Ephrin_rec_like	310..360	CDD:429604
		CCP	378..434	CDD:153056
		CCP	438..494	CDD:153056
		HYR	560..642	CDD:460572
		HYR	644..722	CDD:460572
		O-glycosylated at one site	887..894
		Ephrin_rec_like	1005..1052	CDD:429604
		Ephrin_rec_like	1059..1106	CDD:429604
		Ephrin_rec_like	1113..1160	CDD:429604
		EGF_CA	1196..1229	CDD:238011
		EGF_CA	1231..1267	CDD:238011
		EGF_CA	1269..1305	CDD:238011
		EGF_CA	1308..1342	CDD:238011
		EGF_CA	1345..1381	CDD:238011
		EGF_CA	1383..1419	CDD:238011
		LamG	1424..1622	CDD:473984
		Sushi	1628..1685	CDD:459664
		CCP	1690..1743	CDD:153056
		EGF_CA	1745..1783	CDD:214542
		PHA02927	1789..2017	CDD:222943
		PHA02817	1958..>2079	CDD:165167
		PHA02927	2094..2319	CDD:222943
		PHA02831	2280..>2436	CDD:165176
		PHA02927	2401..2609	CDD:222943
		Important for the interaction with integrin ITGA9:ITGB1. /evidence=ECO:0000250|UniProtKB:A2AVA0	2639..2646
		CCP	<2670..2713	CDD:153056
		PHA02639	2714..>2887	CDD:165022
		PHA02639	2833..>3003	CDD:165022
		Cell attachment site. /evidence=ECO:0000255	2845..2847
		PHA02927	3015..3229	CDD:222943	1/5 (20%)
		PHA02927	3195..3411	CDD:222943	37/205 (18%)
		CCP	3416..3469	CDD:153056	11/52 (21%)