DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment slow and mec-9

DIOPT Version :9

Sequence 1:	NP_647898.3	Gene:	slow / 38540	FlyBaseID:	FBgn0035539	Length:	512	Species:	Drosophila melanogaster
Sequence 2:	NP_001256153.1	Gene:	mec-9 / 179382	WormBaseID:	WBGene00003173	Length:	838	Species:	Caenorhabditis elegans

Alignment Length:	286	Identity:	61/286 - (21%)
Similarity:	92/286 - (32%)	Gaps:	108/286 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly   269 WKHVATPCQ-PPTFSGQKCTRVQVVHEQAYRDVIDHKTAQQMTYDCCTGWSRENPRSDSCMKPIC 332
            ||.....|: .|.|.|..|.:|                   :.||.|.    |.|
Worm   568 WKKDTHYCKCQPGFHGNNCDKV-------------------VDYDPCA----EKP---------- 599

  Fly   333 SARCQNGGNC----------TAPS-TCSCPTGFTGRFCEQDVDECQTEKPCDQQ-CINT------ 379
               |.||..|          ..|: .|.|..||.|..|:|        :||:.. |:|.
Worm   600 ---CLNGATCQIKYNDDDVDEKPTFECFCAAGFGGPKCDQ--------RPCESNPCLNNGTCRTT 653

  Fly   380 --HGSYFCRCRQGFVLQSDQQSCKKVS---TNADDAF--EARDLENDIDDTDAEVATRLQKI--- 434
              :.:|||.|..||    ..::| .||   |..::.|  ....:.:..::..|::..||::.
Worm   654 KGYSTYFCECANGF----GGKNC-DVSIGNTPPEEKFGKNVEQISSGKEEWIAQMRQRLKETGGG 713

  Fly   435 ---------------------EKSLANERVHTNELQKSLQAT---YSVVDTLKSRLSTLEK---- 471
                                 ||| ..::...|:..|:.|..   |....|.|......||
Worm   714 IGGASGSGLKSENGTMGGSSGEKS-GEKKSGKNKKSKATQVADEPYKDPATRKREREEREKKEAE 777

  Fly   472 -QAQDVSRLQTNLYKTESRTNKLEGM 496
             ||.:....|...|:.:::..|.|.|
Worm   778 IQAAEEEEKQRKEYEEDAQRKKAEEM 803

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
slow	NP_647898.3	EMI	246..318	CDD:284877	11/49 (22%)
		EGF_CA	<336..360	CDD:238011	10/34 (29%)
		EGF_CA	362..401	CDD:214542	10/47 (21%)
mec-9	NP_001256153.1	Kunitz_BPTI	35..87	CDD:278443
		Kunitz_BPTI	100..154	CDD:278443
		EGF_CA	199..238	CDD:284955
		EGF_3	283..318	CDD:289699
		KU	323..381	CDD:197529
		KU	<408..449	CDD:197529
		KU	460..516	CDD:197529
		EGF_CA	550..586	CDD:238011	6/17 (35%)
		EGF	639..671	CDD:278437	9/35 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	0	0.000