DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment DopEcR and adra1d

DIOPT Version :9

Sequence 1:	NP_001014559.1	Gene:	DopEcR / 38539	FlyBaseID:	FBgn0035538	Length:	322	Species:	Drosophila melanogaster
Sequence 2:	XP_697043.2	Gene:	adra1d / 568614	ZFINID:	ZDB-GENE-090312-203	Length:	491	Species:	Danio rerio

Alignment Length:	347	Identity:	79/347 - (22%)
Similarity:	160/347 - (46%)	Gaps:	55/347 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 NSKVEALTKAVLISILGVAI---------VLSNLLIIATYANFKGPTEVINYYLLSLAIADLLCG 65
            |:..|.:|  :...::||.|         ::.|:|:|.:....|....|.|:::::|||||||..
Zfish    24 NTTCEGIT--LDSQVIGVGIFLAIFISVAIVGNILVILSVLCNKHLQTVTNFFIVNLAIADLLLS 86

  Fly    66 LLVVPFSVYPALTGEWMYGDIVCRFTGYLEVTLWAVSVYTFMWISVDRYLAVRKPLRYETVQTKT 130
            ::|:|||....:.|.|::|.:.|.....::|.....|:.:...||:|||:.|:..|:|.|:.|:.
Zfish    87 IIVLPFSASLEVLGCWVFGRVFCNIWAAVDVLCCTASILSLCVISIDRYIGVKHCLKYPTIMTER 151

  Fly   131 RCQCWMVFTWISAALLCCPPILGYSMPIENNMTHICML-DWGNMAAYSATLAILVLGPSLISIVH 194
            :....:|..|:|:.::...|:||:..|..::.: ||.: :....|.:|:..:..:  |.::.:|
Zfish   152 KAGVILVLVWVSSMVISIGPLLGWKEPPPSDES-ICRITEEPGYALFSSLFSFYL--PLMVILV- 212

  Fly   195 NYGYIFVMMRK----IRSG-EPIHDKE-------YATALAENLSNPS-------------HMMSF 234
            .|..::::.|:    :.:| :...||.       :..::.|:.|..|             .:|.|
Zfish   213 MYIRVYIVARRTTKSLEAGVKRERDKSMEVVLRIHCRSMPEDSSTSSKTKNHPFRSSLSVRLMKF 277

  Fly   235 A-----------LVFAFWVSWLPWILLRLYEVVTGDVIQSTLINFAVVWIGILNSFWKILIMTSM 288
            :           :|..|.:.|||:..:.........:..|.::...:.|:|..||....:|....
Zfish   278 SREKKAAKTLAIVVGMFILCWLPFFFVLPLGSFFPALKPSDMVFKVIFWLGYFNSCINPIIYPCS 342

  Fly   289 SPQFRIALRVFCLTICCKTKGR 310
            |.:|:   |.|...:.|:.:.|
Zfish   343 SKEFQ---RAFTRLLRCQCQRR 361

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
DopEcR	NP_001014559.1	7tm_classA_rhodopsin-like	18..289	CDD:410626	70/316 (22%)
		TM helix 1	18..42	CDD:410626	6/32 (19%)
		TM helix 2	51..73	CDD:410626	11/21 (52%)
		TM helix 3	89..111	CDD:410626	3/21 (14%)
		TM helix 4	134..150	CDD:410626	3/15 (20%)
		TM helix 5	174..197	CDD:410626	4/22 (18%)
		TM helix 6	230..252	CDD:410626	7/32 (22%)
		TM helix 7	264..289	CDD:410626	5/24 (21%)
adra1d	XP_697043.2	7tm_4	49..350	CDD:304433	70/307 (23%)
adra1d	XP_697043.2	7tm_1	53..339	CDD:278431	66/289 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24248
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	2.010