DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment DopEcR and adra1bb

DIOPT Version :9

Sequence 1:	NP_001014559.1	Gene:	DopEcR / 38539	FlyBaseID:	FBgn0035538	Length:	322	Species:	Drosophila melanogaster
Sequence 2:	NP_001007359.1	Gene:	adra1bb / 492486	ZFINID:	ZDB-GENE-041114-51	Length:	481	Species:	Danio rerio

Alignment Length:	348	Identity:	85/348 - (24%)
Similarity:	151/348 - (43%)	Gaps:	74/348 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    16 LTKAVLIS-ILGVAI---VLSNLLIIATYA---NFKGPTEVINYYLLSLAIADLLCGLLVVPFSV 73
            |::||.:. :||..|   :..|:|:|.:..   :.:.||   ||::::|||||||.|..|:|.|.
Zfish    44 LSRAVPLGLVLGFFITFAIAGNILVILSVVCNRHLRSPT---NYFIVNLAIADLLLGTTVLPVSA 105

  Fly    74 YPALTGEWMYGDIVCRFTGYLEVTLWAVSVYTFMWISVDRYLAVRKPLRYETVQTKTRCQCWMVF 138
            ...:.|.|::|.|.|.....::|.....|:.:...||:|||:.|..||:|..:.|..|....|:.
Zfish   106 TLEVVGHWVFGRIFCDVWAAVDVLCCTASIMSLCVISIDRYIGVSHPLQYPNIVTGRRALLAMLG 170

  Fly   139 TWISAALLCCPPILGYSMPIENNMTHICMLDWGNMAAYSATLAILVLGPSLISIVHNYGYIFVMM 203
            .|:.:.::...|:||:..|...:.| :|.::.....|..::|....:  .||.|:..|..::|:.
Zfish   171 VWVLSLVISIGPLLGWKEPPSPDDT-VCAINEEPFYALFSSLGSFYI--PLIVILVMYCRVYVVA 232

  Fly   204 R----------------------KIRSGEPIHD---KEYATALAENLSNPSHMMSFA-------- 235
            :                      :|..|..:|:   |..|.....:|:  ..::.|:
Zfish   233 KRTTKNLEAGVKTESMNSGEITLRIHRGSQVHEDAGKSRAHQARNSLT--VKLLKFSREKKAAKT 295

  Fly   236 ---LVFAFWVSWLPWIL----------LRLYEVVTGDVIQSTLINFAVVWIGILNSFWKILIMTS 287
               :|..|.:.|||:.|          ||..|.|:.          .:.|:|..||....:|...
Zfish   296 LGVVVGMFTLCWLPFFLTLPIVSFNTSLRPPETVSS----------IIFWLGYFNSCLNPIIYPC 350

  Fly   288 MSPQFRIALRVFCLTICCKTKGR 310
            .|.:|::|   |...:.|:.:.|
Zfish   351 YSREFKLA---FIRILKCRCRRR 370

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
DopEcR	NP_001014559.1	7tm_classA_rhodopsin-like	18..289	CDD:410626	78/323 (24%)
		TM helix 1	18..42	CDD:410626	8/30 (27%)
		TM helix 2	51..73	CDD:410626	12/21 (57%)
		TM helix 3	89..111	CDD:410626	3/21 (14%)
		TM helix 4	134..150	CDD:410626	2/15 (13%)
		TM helix 5	174..197	CDD:410626	5/22 (23%)
		TM helix 6	230..252	CDD:410626	8/42 (19%)
		TM helix 7	264..289	CDD:410626	5/24 (21%)
adra1bb	NP_001007359.1	7tm_4	61..>228	CDD:304433	50/172 (29%)
adra1bb	NP_001007359.1	7tm_1	64..348	CDD:278431	72/301 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910