DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment DopEcR and mAChR-A

DIOPT Version :9

Sequence 1:	NP_001014559.1	Gene:	DopEcR / 38539	FlyBaseID:	FBgn0035538	Length:	322	Species:	Drosophila melanogaster
Sequence 2:	NP_523844.2	Gene:	mAChR-A / 37892	FlyBaseID:	FBgn0000037	Length:	805	Species:	Drosophila melanogaster

Alignment Length:	180	Identity:	51/180 - (28%)
Similarity:	73/180 - (40%)	Gaps:	34/180 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    23 SILGVAIVLSNLLIIATYANFKGPTEVINYYLLSLAIADLLCGLLVVPFSVYPALTGEWMYGDIV 87
            :||....|..|::::.::...|....:.||:|.||||||...|.:.:|......:.|.|..|.||
  Fly   112 AILSTVTVAGNVMVMISFKIDKQLQTISNYFLFSLAIADFAIGAISMPLFAVTTILGYWPLGPIV 176

  Fly    88 CRFTGYLEVTLWAVSVYTFMWISVDRYLAVRKPLRYETVQTKTRCQCWMVFTWISAALLCCPPIL 152
            |.....|:......||...:.||.|||.:|.:||.|...:|..|....:...| ..:||..||.:
  Fly   177 CDTWLALDYLASNASVLNLLIISFDRYFSVTRPLTYRAKRTTNRAAVMIGAAW-GISLLLWPPWI 240

  Fly   153 GYSMP-----------------IENN---------------MTHICMLDW 170
             ||.|                 ||.|               :|.:|.|.|
  Fly   241 -YSWPYIEGKRTVPKDECYIQFIETNQYITFGTALAAFYFPVTIMCFLYW 289

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
DopEcR	NP_001014559.1	7tm_classA_rhodopsin-like	18..289	CDD:410626	51/180 (28%)
		TM helix 1	18..42	CDD:410626	4/18 (22%)
		TM helix 2	51..73	CDD:410626	11/21 (52%)
		TM helix 3	89..111	CDD:410626	4/21 (19%)
		TM helix 4	134..150	CDD:410626	3/15 (20%)
		TM helix 5	174..197	CDD:410626
		TM helix 6	230..252	CDD:410626
		TM helix 7	264..289	CDD:410626
mAChR-A	NP_523844.2	7tm_4	117..>241	CDD:304433	39/125 (31%)
mAChR-A	NP_523844.2	7tm_1	121..>314	CDD:278431	48/171 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45460671
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.930