DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment DopEcR and Adra1d

DIOPT Version :9

Sequence 1:	NP_001014559.1	Gene:	DopEcR / 38539	FlyBaseID:	FBgn0035538	Length:	322	Species:	Drosophila melanogaster
Sequence 2:	NP_077809.2	Gene:	Adra1d / 29413	RGDID:	62064	Length:	562	Species:	Rattus norvegicus

Alignment Length:	348	Identity:	82/348 - (23%)
Similarity:	145/348 - (41%)	Gaps:	60/348 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    15 ALTKAVLISILGVAI-----------VLSNLLIIATYANFKGPTEVINYYLLSLAIADLLCGLLV 68
            |....:::|..||.:           |..|||:|.:.|..:....|.||::::||:||||....|
  Rat    79 AAVGGLVVSAQGVGVGVFLAAFILTAVAGNLLVILSVACNRHLQTVTNYFIVNLAVADLLLSAAV 143

  Fly    69 VPFSVYPALTGEWMYGDIVCRFTGYLEVTLWAVSVYTFMWISVDRYLAVRKPLRYETVQTKTRCQ 133
            :|||....:.|.|.:|...|.....::|.....|:.:...||||||:.||..|:|..:.|:.:..
  Rat   144 LPFSATMEVLGFWAFGRTFCDVWAAVDVLCCTASILSLCTISVDRYVGVRHSLKYPAIMTERKAA 208

  Fly   134 CWMVFTWISAALLCCPPILGYSMPIENNMTHICMLDWGNMAAYSATLAILVLGPSLISIVHNYGY 198
            ..:...|..|.::...|:||:..|:..:.....:.:....|.:|:..:..:  |..: ||..|..
  Rat   209 AILALLWAVALVVSVGPLLGWKEPVPPDERFCGITEEVGYAIFSSVCSFYL--PMAV-IVVMYCR 270

  Fly   199 IFVM----MRKIRSG---EP---------IHDKEYATA--------------LAENLSNPSHMMS 233
            ::|:    .|.:.:|   ||         ||.:..||:              |..:||  ..::.
  Rat   271 VYVVARSTTRSLEAGIKREPGKASEVVLRIHCRGAATSAKGYPGTQSSKGHTLRSSLS--VRLLK 333

  Fly   234 FA-----------LVFAFWVSWLPWILLRLYEVVTGDVIQSTLINFAVVWIGILNSFWKILIMTS 287
            |:           :|..|.:.|.|:..:.....:...:..|..:...:.|:|..||....||...
  Rat   334 FSREKKAAKTLAIVVGVFVLCWFPFFFVLPLGSLFPQLKPSEGVFKVIFWLGYFNSCVNPLIYPC 398

  Fly   288 MSPQFRIALRVFCLTICCKTKGR 310
            .|.:|:   |.|...:.|:.:.|
  Rat   399 SSREFK---RAFLRLLRCQCRRR 418

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
DopEcR	NP_001014559.1	7tm_classA_rhodopsin-like	18..289	CDD:410626	75/322 (23%)
		TM helix 1	18..42	CDD:410626	8/34 (24%)
		TM helix 2	51..73	CDD:410626	11/21 (52%)
		TM helix 3	89..111	CDD:410626	3/21 (14%)
		TM helix 4	134..150	CDD:410626	2/15 (13%)
		TM helix 5	174..197	CDD:410626	5/22 (23%)
		TM helix 6	230..252	CDD:410626	5/32 (16%)
		TM helix 7	264..289	CDD:410626	6/24 (25%)
Adra1d	NP_077809.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	10..71
		7tm_GPCRs	91..407	CDD:421689	76/323 (24%)
		TM helix 1	92..118	CDD:410628	6/25 (24%)
		TM helix 2	125..151	CDD:410628	12/25 (48%)
		TM helix 3	163..193	CDD:410628	9/29 (31%)
		TM helix 4	205..228	CDD:410628	3/22 (14%)
		TM helix 5	245..274	CDD:410628	6/31 (19%)
		TM helix 6	335..365	CDD:410628	4/29 (14%)
		TM helix 7	375..400	CDD:410628	6/24 (25%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	452..481
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24248
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.100