DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment DopEcR and Adra2b

DIOPT Version :9

Sequence 1:	NP_001014559.1	Gene:	DopEcR / 38539	FlyBaseID:	FBgn0035538	Length:	322	Species:	Drosophila melanogaster
Sequence 2:	NP_612514.2	Gene:	Adra2b / 24174	RGDID:	2057	Length:	453	Species:	Rattus norvegicus

Alignment Length:	219	Identity:	62/219 - (28%)
Similarity:	106/219 - (48%)	Gaps:	17/219 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 QEMSYLQDNSKV-EALTKAVLISILGVAIVLSNLLIIATYANFKGPTEVINYYLLSLAIADLLCG 65
            ||...:|..:.: .|:|..:|.:|.|.|:|   :|.:.|..:.:.|.   |.:|:|||.||:|..
  Rat     9 QEPYSVQATAAIASAITFLILFTIFGNALV---ILAVLTSRSLRAPQ---NLFLVSLAAADILVA 67

  Fly    66 LLVVPFSVYPALTGEWMYGDIVCRFTGYLEVTLWAVSVYTFMWISVDRYLAVRKPLRYETVQTKT 130
            .|::|||:...|.|.|.:....|.....|:|.....|:.....||:|||.||.:.|.|.:.:|..
  Rat    68 TLIIPFSLANELLGYWYFWRAWCEVYLALDVLFCTSSIVHLCAISLDRYWAVSRALEYNSKRTPR 132

  Fly   131 RCQCWMVFTWISAALLCCPPIL--GYSMPIENNMTHICMLD---W----GNMAAYSATLAILVLG 186
            |.:|.::..|:.||::..||::  |...|....:.. |.|:   |    .::.::.|...|::|.
  Rat   133 RIKCIILTVWLIAAVISLPPLIYKGDQRPEPRGLPQ-CELNQEAWYILASSIGSFFAPCLIMILV 196

  Fly   187 PSLISIVHNYGYIFVMMRKIRSGE 210
            ...|.::....:...:..|..|||
  Rat   197 YLRIYVIAKRSHCRGLGAKRGSGE 220

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
DopEcR	NP_001014559.1	7tm_classA_rhodopsin-like	18..289	CDD:410626	57/202 (28%)
		TM helix 1	18..42	CDD:410626	7/23 (30%)
		TM helix 2	51..73	CDD:410626	11/21 (52%)
		TM helix 3	89..111	CDD:410626	4/21 (19%)
		TM helix 4	134..150	CDD:410626	4/15 (27%)
		TM helix 5	174..197	CDD:410626	4/22 (18%)
		TM helix 6	230..252	CDD:410626
		TM helix 7	264..289	CDD:410626
Adra2b	NP_612514.2	7tm_4	26..>157	CDD:304433	44/136 (32%)
		7tm_1	34..429	CDD:278431	55/194 (28%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	213..331		4/8 (50%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	1	1.000