DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment DopEcR and Adra1b

DIOPT Version :9

Sequence 1:	NP_001014559.1	Gene:	DopEcR / 38539	FlyBaseID:	FBgn0035538	Length:	322	Species:	Drosophila melanogaster
Sequence 2:	NP_058687.2	Gene:	Adra1b / 24173	RGDID:	2054	Length:	515	Species:	Rattus norvegicus

Alignment Length:	351	Identity:	90/351 - (25%)
Similarity:	154/351 - (43%)	Gaps:	66/351 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 NSKVEAL--TKAVLIS-ILGVAI---VLSNLLIIATYA---NFKGPTEVINYYLLSLAIADLLCG 65
            ||.:..|  |:|:.:. :||..|   ::.|:|:|.:.|   :.:.||   ||::::|||||||..
  Rat    34 NSTLPQLDVTRAISVGLVLGAFILFAIVGNILVILSVACNRHLRTPT---NYFIVNLAIADLLLS 95

  Fly    66 LLVVPFSVYPALTGEWMYGDIVCRFTGYLEVTLWAVSVYTFMWISVDRYLAVRKPLRYETVQTKT 130
            ..|:|||....:.|.|:.|.|.|.....::|.....|:.:...||:|||:.||..|:|.|:.|:.
  Rat    96 FTVLPFSATLEVLGYWVLGRIFCDIWAAVDVLCCTASILSLCAISIDRYIGVRYSLQYPTLVTRR 160

  Fly   131 RCQCWMVFTWISAALLCCPPILGYSMPIENNMTHICMLDWGNMAAYSATLAILVLGPSLISIVHN 195
            :....::..|:.:.::...|:||:..|..|:... |.:......|..::|....:..::|.:::.
  Rat   161 KAILALLSVWVLSTVISIGPLLGWKEPAPNDDKE-CGVTEEPFYALFSSLGSFYIPLAVILVMYC 224

  Fly   196 YGYIF-----------VMMRKIRSGE---PIHDKEYATALAENLS-------NPSHMMSFAL--- 236
            ..||.           ||.....|.|   .||.|.:.   .:.||       ||...::..|
  Rat   225 RVYIVAKRTTKNLEAGVMKEMSNSKELTLRIHSKNFH---EDTLSSTKAKGHNPRSSIAVKLFKF 286

  Fly   237 -------------VFAFWVSWLPWILLRLYEVVTGDVIQSTL-----INFAVVWIGILNSFWKIL 283
                         |..|.:.|||:.:    .:..|.:. |||     :...|.|:|..||....:
  Rat   287 SREKKAAKTLGIVVGMFILCWLPFFI----ALPLGSLF-STLKPPDAVFKVVFWLGYFNSCLNPI 346

  Fly   284 IMTSMSPQFRIALRVFCLTICCKTKG 309
            |....|.:|:   |.|...:.|:.:|
  Rat   347 IYPCSSKEFK---RAFMRILGCQCRG 369

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
DopEcR	NP_001014559.1	7tm_classA_rhodopsin-like	18..289	CDD:410626	80/319 (25%)
		TM helix 1	18..42	CDD:410626	8/30 (27%)
		TM helix 2	51..73	CDD:410626	12/21 (57%)
		TM helix 3	89..111	CDD:410626	3/21 (14%)
		TM helix 4	134..150	CDD:410626	1/15 (7%)
		TM helix 5	174..197	CDD:410626	3/22 (14%)
		TM helix 6	230..252	CDD:410626	6/37 (16%)
		TM helix 7	264..289	CDD:410626	8/29 (28%)
Adra1b	NP_058687.2	7tmA_alpha1B_AR	46..359	CDD:320449	82/327 (25%)
		TM helix 1	48..72	CDD:320449	6/23 (26%)
		TM helix 2	81..103	CDD:320449	12/21 (57%)
		TM helix 3	119..141	CDD:320449	3/21 (14%)
		TM helix 4	164..180	CDD:320449	1/15 (7%)
		TM helix 5	201..224	CDD:320449	3/22 (14%)
		TM helix 6	293..315	CDD:320449	5/25 (20%)
		TM helix 7	327..352	CDD:320449	6/24 (25%)
		Nuclear localization signal. /evidence=ECO:0000250	368..378		1/2 (50%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	392..430
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	474..515
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910