Protein Alignment DopEcR and ADRA1A

DIOPT Version :10

• Sequence 1: NP_647897.2
• Gene: DopEcR / 38539
• FlyBaseID: FBgn0035538
• Length: 322
• Species: Drosophila melanogaster
• Sequence 2: NP_150646.3
• Gene: ADRA1A / 148
• HGNCID: 277
• Length: 475
• Species: Homo sapiens
• Alignment Length: 343
• Identity: 88/343 - (25%)
• Similarity: 152/343 - (44%)
• Gaps: 60/343 - (17%)

  Fly    16 LTKAVLIS-ILGVAI---VLSNLLIIATYANFKGPTEVINYYLLSLAIADLLCGLLVVPFSVYPA 76
            ::||:|:. |||..|   ||.|:|:|.:.|..:....|.:||:::||:||||....|:|||....
Human    23 ISKAILLGVILGGLILFGVLGNILVILSVACHRHLHSVTHYYIVNLAVADLLLTSTVLPFSAIFE 87

  Fly    77 LTGEWMYGDIVCRFTGYLEVTLWAVSVYTFMWISVDRYLAVRKPLRYETVQTKTRCQCWMVFTWI 141
            :.|.|.:|.:.|.....::|.....|:.....||:|||:.|..||||.|:.|:.|....::..|.
Human    88 VLGYWAFGRVFCNIWAAVDVLCCTASIMGLCIISIDRYIGVSYPLRYPTIVTQRRGLMALLCVWA 152

  Fly   142 SAALLCCPPILGYSMPIENNMTHICMLD-------WGNMAAYSATLAILVLGPSLISIVHNYGYI 199
            .:.::...|:.|:..|...:.| ||.::       :..:.::...|||:::         .|..:
Human   153 LSLVISIGPLFGWRQPAPEDET-ICQINEEPGYVLFSALGSFYLPLAIILV---------MYCRV 207

  Fly   200 FVMMRK----IRSG--EPIHDKEYATALAENLSNPS----------------HMMSFA------- 235
            :|:.::    ::||  ....|.|..|......:.|:                .::.|:
Human   208 YVVAKRESRGLKSGLKTDKSDSEQVTLRIHRKNAPAGGSGMASAKTKTHFSVRLLKFSREKKAAK 272

  Fly   236 ----LVFAFWVSWLPWILLRLYEVVTGDVIQSTLINFAVVWIGILNSFWKILIMTSMSPQFRIA- 295
                :|..|.:.|||:.|:........|...|..:...|.|:|.|||....:|....|.:|:.|
Human   273 TLGIVVGCFVLCWLPFFLVMPIGSFFPDFKPSETVFKIVFWLGYLNSCINPIIYPCSSQEFKKAF 337

  Fly   296 ---LRVFCLTICCKTKGR 310
               ||:.||  |.|...:
Human   338 QNVLRIQCL--CRKQSSK 353

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
DopEcR	NP_647897.2	7tm_classA_rhodopsin-like	18..289	CDD:410626	79/314 (25%)
		TM helix 1	18..43	CDD:410626	13/28 (46%)
		TM helix 2	50..76	CDD:410626	12/25 (48%)
		TM helix 3	88..118	CDD:410626	8/29 (28%)
		TM helix 4	131..150	CDD:410626	2/18 (11%)
		TM helix 5	173..198	CDD:410626	4/24 (17%)
		TM helix 6	224..254	CDD:410626	8/56 (14%)
		TM helix 7	264..289	CDD:410626	7/24 (29%)
ADRA1A	NP_150646.3	7tmA_alpha1A_AR	27..337	CDD:320448	79/319 (25%)
		TM helix 1	28..54	CDD:320448	11/25 (44%)
		TM helix 2	61..87	CDD:320448	12/25 (48%)
		TM helix 3	99..129	CDD:320448	8/29 (28%)
		TM helix 4	141..164	CDD:320448	3/22 (14%)
		TM helix 5	181..210	CDD:320448	4/37 (11%)
		TM helix 6	265..295	CDD:320448	6/29 (21%)
		TM helix 7	305..330	CDD:320448	7/24 (29%)
		Nuclear localization signal	334..349		6/16 (38%)