DRSC/TRiP Functional Genomics Resources

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Protein Alignment DopEcR and ADRA1D

DIOPT Version :9

Sequence 1:NP_001014559.1 Gene:DopEcR / 38539 FlyBaseID:FBgn0035538 Length:322 Species:Drosophila melanogaster
Sequence 2:NP_000669.1 Gene:ADRA1D / 146 HGNCID:280 Length:572 Species:Homo sapiens


Alignment Length:351 Identity:81/351 - (23%)
Similarity:141/351 - (40%) Gaps:66/351 - (18%)


- Green bases have known domain annotations that are detailed below.


  Fly    15 ALTKAVLISILGVAI-----------VLSNLLIIATYANFKGPTEVINYYLLSLAIADLLCGLLV 68
            |....:::|..||.:           |..|||:|.:.|..:....|.||::::||:||||....|
Human    85 AAVGGLVVSAQGVGVGVFLAAFILMAVAGNLLVILSVACNRHLQTVTNYFIVNLAVADLLLSATV 149

  Fly    69 VPFSVYPALTGEWMYGDIVCRFTGYLEVTLWAVSVYTFMWISVDRYLAVRKPLRYETVQTKTRCQ 133
            :|||....:.|.|.:|...|.....::|.....|:.:...||||||:.||..|:|..:.|:.:..
Human   150 LPFSATMEVLGFWAFGRAFCDVWAAVDVLCCTASILSLCTISVDRYVGVRHSLKYPAIMTERKAA 214

  Fly   134 CWMVFTWISAALLCCPPILGYSMPIENNMTHICMLDWGNMAAYSATLAILVLGPSLISIVHNYGY 198
            ..:...|:.|.::...|:||:..|:..:.....:.:....|.:|:..:..:  |..: ||..|..
Human   215 AILALLWVVALVVSVGPLLGWKEPVPPDERFCGITEEAGYAVFSSVCSFYL--PMAV-IVVMYCR 276

  Fly   199 IFVMMRK-IRSGEP---------------IHDKEYATALAENLSNPSHMMSFA------------ 235
            ::|:.|. .||.|.               ||.:..||.     ::.:|.|..|            
Human   277 VYVVARSTTRSLEAGVKRERGKASEVVLRIHCRGAATG-----ADGAHGMRSAKGHTFRSSLSVR 336

  Fly   236 ----------------LVFAFWVSWLPWILLRLYEVVTGDVIQSTLINFAVVWIGILNSFWKILI 284
                            :|..|.:.|.|:..:.....:...:..|..:...:.|:|..||....||
Human   337 LLKFSREKKAAKTLAIVVGVFVLCWFPFFFVLPLGSLFPQLKPSEGVFKVIFWLGYFNSCVNPLI 401

  Fly   285 MTSMSPQFRIALRVFCLTICCKTKGR 310
            ....|.:|:   |.|...:.|:.:.|
Human   402 YPCSSREFK---RAFLRLLRCQCRRR 424

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
DopEcRNP_001014559.1 7tm_classA_rhodopsin-like 18..289 CDD:410626 74/325 (23%)
TM helix 1 18..42 CDD:410626 8/34 (24%)
TM helix 2 51..73 CDD:410626 11/21 (52%)
TM helix 3 89..111 CDD:410626 3/21 (14%)
TM helix 4 134..150 CDD:410626 2/15 (13%)
TM helix 5 174..197 CDD:410626 5/22 (23%)
TM helix 6 230..252 CDD:410626 7/49 (14%)
TM helix 7 264..289 CDD:410626 6/24 (25%)
ADRA1DNP_000669.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..77
7tmA_alpha1D_AR 97..413 CDD:320450 75/326 (23%)
TM helix 1 98..124 CDD:320450 6/25 (24%)
TM helix 2 131..157 CDD:320450 12/25 (48%)
TM helix 3 169..199 CDD:320450 9/29 (31%)
TM helix 4 211..234 CDD:320450 3/22 (14%)
TM helix 5 251..280 CDD:320450 6/31 (19%)
TM helix 6 341..371 CDD:320450 4/29 (14%)
TM helix 7 381..406 CDD:320450 6/24 (25%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 444..488
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR24248
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
22.010

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