Protein Alignment DopEcR and Adra1d

DIOPT Version :10

• Sequence 1: NP_647897.2
• Gene: DopEcR / 38539
• FlyBaseID: FBgn0035538
• Length: 322
• Species: Drosophila melanogaster
• Sequence 2: NP_038488.4
• Gene: Adra1d / 11550
• MGIID: 106673
• Length: 562
• Species: Mus musculus
• Alignment Length: 346
• Identity: 82/346 - (23%)
• Similarity: 143/346 - (41%)
• Gaps: 56/346 - (16%)

  Fly    15 ALTKAVLISILGVAI-----------VLSNLLIIATYANFKGPTEVINYYLLSLAIADLLCGLLV 68
            |....:::|..||.:           |..|||:|.:.|..:....|.||::::||:||||....|
Mouse    79 AAVGGLVVSAQGVGVGVFLAAFILTAVAGNLLVILSVACNRHLQTVTNYFIVNLAVADLLLSAAV 143

  Fly    69 VPFSVYPALTGEWMYGDIVCRFTGYLEVTLWAVSVYTFMWISVDRYLAVRKPLRYETVQTKTRCQ 133
            :|||....:.|.|.:|...|.....::|.....|:.:...||||||:.||..|:|..:.|:.:..
Mouse   144 LPFSATMEVLGFWAFGRTFCDVWAAVDVLCCTASILSLCTISVDRYVGVRHSLKYPAIMTERKAA 208

  Fly   134 CWMVFTWISAALLCCPPILGYSMPIENNMTHICMLDWGNMAAYSATLAILVLGPSLISIVHNYGY 198
            ..:...|..|.::...|:||:..|:..:.....:.:....|.:|:..:..:  |..: ||..|..
Mouse   209 AILALLWAVALVVSVGPLLGWKEPVPPDERFCGITEEVGYAIFSSVCSFYL--PMAV-IVVMYCR 270

  Fly   199 IFVM----MRKIRSG---EP---------IHDKEYATALAEN---LSNPSHMMSFAL-------- 236
            ::|:    .|.:.:|   ||         ||.:..||:...|   .|:..|.:..:|
Mouse   271 VYVVARSTTRSLEAGIKREPGKASEVVLRIHCRGAATSAKGNPGTQSSKGHTLRSSLSVRLLKFS 335

  Fly   237 ------------VFAFWVSWLPWILLRLYEVVTGDVIQSTLINFAVVWIGILNSFWKILIMTSMS 289
                        |..|.:.|.|:..:.....:...:..|..:...:.|:|..||....||....|
Mouse   336 REKKAAKTLAIVVGVFVLCWFPFFFVLPLGSLFPQLKPSEGVFKVIFWLGYFNSCVNPLIYPCSS 400

  Fly   290 PQFRIALRVFCLTICCKTKGR 310
            .:|:   |.|...:.|:.:.|
Mouse   401 REFK---RAFLRLLRCQCRRR 418

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
DopEcR	NP_647897.2	7tm_classA_rhodopsin-like	18..289	CDD:410626	75/320 (23%)
		TM helix 1	18..43	CDD:410626	9/35 (26%)
		TM helix 2	50..76	CDD:410626	12/25 (48%)
		TM helix 3	88..118	CDD:410626	9/29 (31%)
		TM helix 4	131..150	CDD:410626	2/18 (11%)
		TM helix 5	173..198	CDD:410626	6/24 (25%)
		TM helix 6	224..254	CDD:410626	8/52 (15%)
		TM helix 7	264..289	CDD:410626	6/24 (25%)
Adra1d	NP_038488.4	7tm_GPCRs	91..407	CDD:475119	76/321 (24%)
		TM helix 1	93..117	CDD:410628	5/23 (22%)
		TM helix 2	126..148	CDD:410628	11/21 (52%)
		TM helix 3	164..186	CDD:410628	3/21 (14%)
		TM helix 4	209..225	CDD:410628	2/15 (13%)
		TM helix 5	246..269	CDD:410628	5/25 (20%)
		TM helix 6	341..363	CDD:410628	4/21 (19%)
		TM helix 7	375..400	CDD:410628	6/24 (25%)