DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cip4 and SRGAP3

DIOPT Version :9

Sequence 1:	NP_001097501.1	Gene:	Cip4 / 38534	FlyBaseID:	FBgn0035533	Length:	665	Species:	Drosophila melanogaster
Sequence 2:	XP_016863063.1	Gene:	SRGAP3 / 9901	HGNCID:	19744	Length:	1117	Species:	Homo sapiens

Alignment Length:	804	Identity:	143/804 - (17%)
Similarity:	255/804 - (31%)	Gaps:	240/804 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    69 TELWDQNENLAIHTNRGIDALDKFANFLRDRVAIETEYAGKLRRLVKNYQPKKKEEEDNEF---- 129
            |:|.:|.:.|...:...:..|.....|.|.:..||.||:..|.:|.:.:..|.:...:::|
Human    44 TQLVEQFKCLEQQSESRLQLLQDLQEFFRRKAEIELEYSRSLEKLAERFSSKIRSSREHQFKKDQ 108

  Fly   130 ---TSVQAFRNLLKEVGDLAGQREVVSESLQLQIIAGVTLLSKTLREERKKCLSDGATLQQNLTT 191
               :.|..:..:|.:....:.....:::.....:|..::.:|:.:....||....|..:.:.|..
Human   109 YLLSPVNCWYLVLHQTRRESRDHATLNDIFMNNVIVRLSQISEDVIRLFKKSKEIGLQMHEELLK 173

  Fly   192 QLSSLDRAKRNYEKAYRDSEKAVDSYKRA------------DMDLNLSRAE-----------VER 233
            ..:.|....:.|...:.:|..|....|.|            |:.:||.|.|           :|:
Human   174 VTNELYTVMKTYHMYHAESISAESKLKEAEKQEEKQFNKSGDLSMNLLRHEDRPQRRSSVKKIEK 238

  Fly   234 YKNVMTSKIQQS----DDAKNEYANQLQKTNNLQQQHYSMLLPSVLNRLQELD----EKRTRGFR 290
            .|....:|..::    ..|:|:|...|..||....::|   :..|.:.:...|    ....|.||
Human   239 MKEKRQAKYSENKLKCTKARNDYLLNLAATNAAISKYY---IHDVSDLIDCCDLGFHASLARTFR 300

  Fly   291 EFIVGAADVESSVAPIIARCMEG---IVKAGESINEKEDTFKVIERYQSGFTPPRDIPFE----- 347
            .::....::|:|       ..||   |..|.::::.:.|...|::.....|.||....|:
Human   301 TYLSAEYNLETS-------RHEGLDVIENAVDNLDSRSDKHTVMDMCNQVFCPPLKFEFQPHMGD 358

  Fly   348 ---DLSKCDPDSVQDS---HYSNSTSNHLTIR-----------GTMSANKLKKRVGIFNIFGSNK 395
               .:|...|  ||..   .|....|...|::           .||...:....|..|::..:.:
Human   359 EVCQVSAQQP--VQTELLMRYHQLQSRLATLKIENEEVRKTLDATMQTLQDMLTVEDFDVSDAFQ 421

  Fly   396 NSLTADGQKEDFSDL----------PPNQRR-------------------KKLQAKIAELTQNIA 431
            :|.:.:..|...|:.          ..||:.                   .|||||...|.|.:.
Human   422 HSRSTESVKSAASETYMSKINIAKRRANQQETEMFYFTKFKEYVNGSNLITKLQAKHDLLKQTLG 486

  Fly   432 QETKARDGLMKMKIVYEANSSLGNPMTVEGQLNESEHKLEKLKVDLKKYQGFLEKASQ-VPTATS 495
            :..:|..|..:...:......:..|.    .|:...|||..     ...:.|::.:.| :|....
Human   487 EGERAECGTTRPPCLPPKPQKMRRPR----PLSVYSHKLFN-----GSMEAFIKDSGQAIPLVVE 542

  Fly   496 S--------------------PQASRNQLQNGHRTSRHSNGSADDHHD--------------DGD 526
            |                    .|...|.::|..  .|..:...||.::              .|.
Human   543 SCIRYINLYGLQQQGIFRVPGSQVEVNDIKNSF--ERGEDPLVDDQNERDINSVAGVLKLYFRGL 605

  Fly   527 DQP--------DDAGSLSRSDSEDNVAQIQNGHNN----------------NNNGSASPESGLGT 567
            :.|        |...::...:..:.|.|||.....                |:....|.|:.:..
Human   606 ENPLFPKERFQDLISTIKLENPAERVHQIQQILVTLPRVVIVVMRYLFAFLNHLSQYSDENMMDP 670

  Fly   568 SHTSL--------------PGSGQGSANE----NAIGEDTYYETEVETLNPV-GKCRA---LYPF 610
            .:.::              |.|.|...||    ..|..:..:.:..|...|| .||.|   .|..
Human   671 YNLAICFGPTLMHIPDGQDPVSCQAHINEVIKTIIIHHEAIFPSPRELEGPVYEKCMAGGEEYCD 735

  Fly   611 EASSE-----------GSIPMSEGEELQVIE----------------IDQG-----------DGW 637
            ...||           |:.|.:..||::.||                ..:|           |.|
Human   736 SPHSEPGAIDEVDHDNGTEPHTSDEEVEQIEAIAKFDYMGRSPRELSFKKGASLLLYHRASEDWW 800

  Fly   638 TRVRRENNSNGWDEGFVPTSYIEI 661
                 |...||.| |.:|..||.:
Human   801 -----EGRHNGVD-GLIPHQYIVV 818

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cip4	NP_001097501.1	F-BAR_CIP4-like	69..319	CDD:153337	55/290 (19%)
		HR1_CIP4-like	412..488	CDD:212009	17/94 (18%)
		SH3_CIP4-like	603..661	CDD:212844	23/98 (23%)
SRGAP3	XP_016863063.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3565
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810