DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cip4 and FCHSD2

DIOPT Version :9

Sequence 1:	NP_001097501.1	Gene:	Cip4 / 38534	FlyBaseID:	FBgn0035533	Length:	665	Species:	Drosophila melanogaster
Sequence 2:	NP_055639.2	Gene:	FCHSD2 / 9873	HGNCID:	29114	Length:	740	Species:	Homo sapiens

Alignment Length:	611	Identity:	127/611 - (20%)
Similarity:	242/611 - (39%)	Gaps:	155/611 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    87 DALDKFANFLRDRVAIETEYAGKLRRLVKNY----QPKKKEEEDNEFTSV-QAFRNLLKEVGDLA 146
            |.|:....|.:.:.|||.|||..:::|...|    .|..|.::.|::.|: ..:::.|:....:|
Human    34 DLLEDMRTFSQKKAAIEREYAQGMQKLASQYLKRDWPGVKADDRNDYRSMYPVWKSFLEGTMQVA 98

  Fly   147 GQREVVSESLQLQIIAGVTLLSKTLREER-KKCLSDGATLQQNLTTQLSSLDRAKRNYEKAYRDS 210
            ..|..:.|:.: ..|:......::|:|:: |:|:.....:|..|...:..|.:.|:.|   :...
Human    99 QSRMNICENYK-NFISEPARTVRSLKEQQLKRCVDQLTKIQTELQETVKDLAKGKKKY---FETE 159

  Fly   211 EKAVDSYKRADMD----LNLSRAEVERYKNVMTSKIQQSD------DAKNEYANQLQKTNNLQQQ 265
            :.|....::||::    |:|.::.:...|..:..|.::|:      .|:|:|...|...|..|.:
Human   160 QMAHAVREKADIEAKSKLSLFQSRISLQKASVKLKARRSECNSKATHARNDYLLTLAAANAHQDR 224

  Fly   266 HYSMLLPSVLNRLQELDEKRTRGFREFIVGAADVESSVAPIIARCMEGIVKAGESINEKEDTFKV 330
            :|.   ..::|.::.||.......:::::..:..|......:....:.::         |::.||
Human   225 YYQ---TDLVNIMKALDGNVYDHLKDYLIAFSRTELETCQAVQNTFQFLL---------ENSSKV 277

  Fly   331 IERY--------QSGFTPPRDIPFEDLSKCDPD-SVQDSHYSNSTSNHLTIRGTMSANKLKKRVG 386
            :..|        .:.|..|:...|:   .||.| |.|....:.:|..|       |.|| :.|..
Human   278 VRDYNLQLFLQENAVFHKPQPFQFQ---PCDSDTSRQLESETGTTEEH-------SLNK-EARKW 331

  Fly   387 IFNIFGSNKNSLTADGQKEDFSDLP------PNQRRKKLQAKIAELTQNIAQ------ETKARDG 439
            ...:...:||.:   .|:...:||.      ..|.|.:|:.||.|..:||.:      :.:||..
Human   332 ATRVAREHKNIV---HQQRVLNDLECHGAAVSEQSRAELEQKIDEARENIRKAEIIKLKAEARLD 393

  Fly   440 LMKMKIVYEANSSLGNPMTVEGQLNESEHKLEKLKVDLKKYQGFLEKASQVPTATSSPQASRNQL 504
            |:| :|....::.|.:.|      |:...:||.            |:.::.|..||
Human   394 LLK-QIGVSVDTWLKSAM------NQVMEELEN------------ERWARPPAVTS--------- 430

  Fly   505 QNGHRTSRHSNGSADDHHDDGDDQPDDAGSLSRSDSEDNVAQIQNGHNNNNNGSASPESGLGTSH 569
             ||   :.||. :||...::|:            :.|||:...       ::.|:||...|
Human   431 -NG---TLHSL-NADTEREEGE------------EFEDNMDVF-------DDSSSSPSGTL---- 467

  Fly   570 TSLPGSGQGSANENAIGEDTYYETEVETLNPVGKCRALYPFEASSEGSIPMSEGEELQVIEIDQG 634
                              ..|..|          |:.:|.::||....:.:.|.|.|:|||....
Human   468 ------------------RNYPLT----------CKVVYSYKASQPDELTIEEHEVLEVIEDGDM 504

  Fly   635 DGWTRVRRENNSNGWDEGFVPTSYIE 660
            :.|.:.|   |..| ..|:||..|::
Human   505 EDWVKAR---NKVG-QVGYVPEKYLQ 526

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cip4	NP_001097501.1	F-BAR_CIP4-like	69..319	CDD:153337	48/247 (19%)
		HR1_CIP4-like	412..488	CDD:212009	19/81 (23%)
		SH3_CIP4-like	603..661	CDD:212844	18/58 (31%)
FCHSD2	NP_055639.2	F-BAR_FCHSD2	16..275	CDD:153361	49/256 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	303..323		7/26 (27%)
		SH3_FCHSD_1	471..527	CDD:212695	19/70 (27%)
		Required and sufficient for location at clathrin-coated pits. /evidence=ECO:0000269\|PubMed:29887380	567..629
		SH3_FCHSD2_2	571..626	CDD:212827
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	633..740
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3565
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D348563at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.820