Protein Alignment Cip4 and TRIP10

DIOPT Version :9

• Sequence 1: NP_001097501.1
• Gene: Cip4 / 38534
• FlyBaseID: FBgn0035533
• Length: 665
• Species: Drosophila melanogaster
• Sequence 2: XP_006723003.1
• Gene: TRIP10 / 9322
• HGNCID: 12304
• Length: 649
• Species: Homo sapiens
• Alignment Length: 636
• Identity: 190/636 - (29%)
• Similarity: 312/636 - (49%)
• Gaps: 120/636 - (18%)

  Fly    65 MSWGTELWDQNENLAIHTNRGIDALDKFANFLRDRVAIETEYAGKLRRLVKNYQPKK--KEEEDN 127
            |.||||||||.|.|..||..|:|.||::..|:::|..:|..||.:||.|||.|.||:  |::.::
Human     1 MDWGTELWDQFEVLERHTQWGLDLLDRYVKFVKERTEVEQAYAKQLRSLVKKYLPKRPAKDDPES 65

  Fly   128 EFTSVQAFRNLLKEVGDLAGQREVVSESLQLQIIAGVTLLSKTLREERKKCLSDGATLQQNLTTQ 192
            :|:..|:|..:|:||.|.|||||:|:|:|.:::...:|..|:.:::|||....:|...||.|...
Human    66 KFSQQQSFVQILQEVNDFAGQRELVAENLSVRVCLELTKYSQEMKQERKMHFQEGRRAQQQLENG 130

  Fly   193 LSSLDRAKRNYEKAYRDSEKAVDSYKRADMDLNLSRAEVERYKNVMTSKIQQSDDAKNEYANQLQ 257
            ...|:.:||.:|:..|::|||..:.:|.|.|:|.::|:||:.|.....:...::::|||||.|||
Human   131 FKQLENSKRKFERDCREAEKAAQTAERLDQDINATKADVEKAKQQAHLRSHMAEESKNEYAAQLQ 195

  Fly   258 KTNNLQQQHYSMLLPSVLNRLQELDEKR-TRGFREFIVGA-----ADVESSVAPIIARCMEGIVK 316
            :.|..|...|...:|.:.::||::||:| ||      :||     ::.|..|.||||:|:||:..
Human   196 RFNRDQAHFYFSQMPQIFDKLQDMDERRATR------LGAGYGLLSEAELEVVPIIAKCLEGMKV 254

  Fly   317 AGESINEKEDTFKVIERYQSGFTPPRDIPFEDLSKCDPDSVQDSHYSNSTSNHLTIRG------- 374
            |..:::.|.|:..:||.::|||..|.|:.|||.|:....:..||.....:.....:||
Human   255 AANAVDPKNDSHVLIELHKSGFARPGDVEFEDFSQPMNRAPSDSSLGTPSDGRPELRGPGRSRTK 319

  Fly   375 -------------------------------------------TMSANKLKKRVGIF-NIFGSNK 395
                                                       :..:..:|.|:..| ::.||..
Human   320 RWPFGKKNKPRPPPLSPLGGPVPSALPNGPPSPRSGRDPLAILSEISKSVKPRLASFRSLRGSRG 384

  Fly   396 NSLTADGQKEDFSDLPPNQRRKKLQAKIAELTQNIAQETKARDGLMKMKIVYEANSSLGNPMTVE 460
            ..:|     ||||.|||.|:||:||.::.|.::.:.:|...|:.|.|||.|||....:|:|.::|
Human   385 TVVT-----EDFSHLPPEQQRKRLQQQLEERSRELQKEVDQREALKKMKDVYEKTPQMGDPASLE 444

  Fly   461 GQLNESEHKLEKLKVDLKKYQGFLEKASQVPTATSSPQASRNQLQNGHRTSRHSNGSADDHHDDG 525
            .|:.|:...:|:||::::||:.:|.:|.           ||.....|...|||:
Human   445 PQIAETLSNIERLKLEVQKYEAWLAEAE-----------SRVLSNRGDSLSRHA----------- 487

  Fly   526 DDQPDDAGSLSRSDSEDNVAQIQNGHNNNNNGSASPESGLGTSHTSLPGSGQGSANENAIGEDTY 590
              :|.|..:.:..||..|.|.     .:....|..|.|              ..:.:..|..:..
Human   488 --RPPDPPASAPPDSSSNSAS-----QDTKESSEEPPS--------------EESQDTPIYTEFD 531

  Fly   591 YETEVETLNPVGKCRALYPFEASSEGSIPMSEGEELQVIEIDQGDGWTRVR 641
            .:.|.|..:|:|.|.|:|.||...... |.|:| ..:.:.:     |.||:
Human   532 EDFEEEPTSPIGHCVAIYHFEDLGPPP-PPSQG-PARALSL-----WPRVK 575

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cip4	NP_001097501.1	F-BAR_CIP4-like	69..319	CDD:153337	99/257 (39%)
		HR1_CIP4-like	412..488	CDD:212009	27/75 (36%)
		SH3_CIP4-like	603..661	CDD:212844	11/39 (28%)
TRIP10	XP_006723003.1	F-BAR_CIP4-like	5..257	CDD:153337	99/257 (39%)
		HR1_CIP4_FNBP1L	395..475	CDD:212018	30/90 (33%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165157761
Domainoid	1	1.000	213	1.000	Domainoid score	I2748
eggNOG	1	0.900	-	-		E1_KOG3565
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	359	1.000	Inparanoid score	I2217
Isobase	1	0.950	-	0	Normalized mean entropy	S4360
OMA	1	1.010	-	-		QHG51860
OrthoDB	1	1.010	-	-		D348563at2759
OrthoFinder	1	1.000	-	-		FOG0001169
OrthoInspector	1	1.000	-	-		otm40537
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR15735
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2056
SonicParanoid	1	1.000	-	-		X890
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	15	14.850