DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cip4 and FCHSD1

DIOPT Version :9

Sequence 1:	NP_001097501.1	Gene:	Cip4 / 38534	FlyBaseID:	FBgn0035533	Length:	665	Species:	Drosophila melanogaster
Sequence 2:	NP_258260.1	Gene:	FCHSD1 / 89848	HGNCID:	25463	Length:	690	Species:	Homo sapiens

Alignment Length:	650	Identity:	124/650 - (19%)
Similarity:	218/650 - (33%)	Gaps:	211/650 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly    70 ELWDQNENLAIHTNRGIDALDKFANFLRDRVAIETEYAGKLRRL----VKNYQPKKKEEEDNEFT 130
            :.|.|.|         .|.|:...::.:.|.|||.||...|::|    :|....:..|.:....|
Human    26 QTWQQRE---------ADLLEDIRSYSKQRAAIEREYGQALQKLAGPFLKREGHRSGEMDSRGRT 81

  Fly   131 SVQAFRNLLKEVGDLAGQREVVSESLQLQIIAGVTLLSKTLREERKKCLSDGA-TLQQNLTTQLS 194
            ...|:|.||.  ..:||.:..:..|.:.:.:||     .|.|..:::.|..|. .||:.....|.
Human    82 VFGAWRCLLD--ATVAGGQTRLQASDRYRDLAG-----GTGRSAKEQVLRKGTENLQRAQAEVLQ 139

  Fly   195 S---LDRAKRNYEKAYR----DSEKAVD---SYKRADMDLNLSRAEVERYKNVMTSK----IQQS 245
            |   |.|:::.|.:..|    ..|||.|   ...|:|..:..||..:::....::::    .||.
Human   140 SVRELSRSRKLYGQRERVWALAQEKAADVQARLNRSDHGIFHSRTSLQKLSTKLSAQSAQYSQQL 204

  Fly   246 DDAKNEYANQLQKTNNLQQQHYSMLLPSVLNRL-QELDEKRTRGFREFIVGAADVESSVAPIIAR 309
            ..|:|||...|..||.....:|...||::|..| .||.|.    .|:.:...:..|...|.:|
Human   205 QAARNEYLLNLVATNAHLDHYYQEELPALLKALVSELSEH----LRDPLTSLSHTELEAAEVI-- 263

  Fly   310 CMEGIVKAGESINEKEDTFKVIERYQSGFTPPRDIPFEDLSKCDPDSVQDSHYSNSTSNHLTIRG 374
                                                           ::.:|....|::.::...
Human   264 -----------------------------------------------LEHAHRGEQTTSQVSWEQ 281

  Fly   375 TMSANKLKKRVGIFNIFGSNKNSLTADGQKEDFSDLPPNQ--------------------RRKKL 419
            .:                  |..|...|.   ||..||.|                    .:..|
Human   282 DL------------------KLFLQEPGV---FSPTPPQQFQPAGTDQVCVLEWGAEGVAGKSGL 325

  Fly   420 QAKIAELTQNIAQETKARDG----LMKMKIVYEANSSLGNPMTVEGQLNESEHKLEKLKVD---- 476
            :.::..||...|::.|.::.    |.:::...:..|....| ::|.:|.|....:.:.:|.
Human   326 EKEVQRLTSRAARDYKIQNHGHRVLQRLEQRRQQASEREAP-SIEQRLQEVRESIRRAQVSQVKG 389

  Fly   477 ---LKKYQG-------FLEKASQVPTATSSPQASRNQLQNGHRTSRHSNGSADDHHDDGDDQPDD 531
               |...||       :|:.|.   |..........:|.....:.|..:.:|:|......::.::
Human   390 AARLALLQGAGLDVERWLKPAM---TQAQDEVEQERRLSEARLSQRDLSPTAEDAELSDFEECEE 451

  Fly   532 AGSLSRSDSEDNVAQIQNGHNNNNNGSASPESGLGTSHTSLPGSGQGSANENAIGEDTYYETEVE 596
            .|.|....:...:|.                       .:||
Human   452 TGELFEEPAPQALAT-----------------------RALP----------------------- 470

  Fly   597 TLNPVGKCRA--LYPFEASSEGSIPMSEGEELQVIEIDQGDGWTRVRRENNSNGWDEGFVPTSYI 659
                   |.|  ::.::|..|..:.::|||.|:|||....|.|.:.|   |.:| :.||||..|:
Human   471 -------CPAHVVFRYQAGREDELTITEGEWLEVIEEGDADEWVKAR---NQHG-EVGFVPERYL 524

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cip4	NP_001097501.1	F-BAR_CIP4-like	69..319	CDD:153337	66/268 (25%)
		HR1_CIP4-like	412..488	CDD:212009	18/113 (16%)
		SH3_CIP4-like	603..661	CDD:212844	21/58 (36%)
FCHSD1	NP_258260.1	F-BAR_FCHSD1	16..275	CDD:153362	68/317 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	422..444		4/21 (19%)
		SH3_FCHSD_1	470..526	CDD:212695	22/88 (25%)
		SH3_FCHSD1_2	550..607	CDD:212828
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	609..690
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3565
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D348563at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2056
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.850