DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cip4 and fnbp1

DIOPT Version :9

Sequence 1:	NP_001097501.1	Gene:	Cip4 / 38534	FlyBaseID:	FBgn0035533	Length:	665	Species:	Drosophila melanogaster
Sequence 2:	XP_031746435.1	Gene:	fnbp1 / 780119	XenbaseID:	XB-GENE-1003118	Length:	684	Species:	Xenopus tropicalis

Alignment Length:	729	Identity:	235/729 - (32%)
Similarity:	363/729 - (49%)	Gaps:	186/729 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    65 MSWGTELWDQNENLAIHTNRGIDALDKFANFLRDRVAIETEYAGKLRRLVKNYQPKK--KEEEDN 127
            ||||||||||.:||..||..||:.|:|:..|:::|..||..||.:||.|.|.||.||  ||||::
Frog     1 MSWGTELWDQFDNLEKHTQWGIEVLEKYIKFVKERTEIEINYAKQLRNLSKKYQTKKNSKEEEES 65

  Fly   128 EFTSVQAFRNLLKEVGDLAGQREVVSESLQLQIIAGVTLLSKTLREERKKCLSDGATLQQNLTTQ 192
            ::||.:||:..|.|:.|.|||.||:||::..||.|.:|...:.:::|||:...:|...||::.|.
Frog    66 KYTSCKAFQATLNEMNDYAGQHEVISENMASQITAELTRFVQEVKQERKQHFHEGRKAQQHIETC 130

  Fly   193 LSSLDRAKRNYEKAYRDSEKAVDSYKRADMDLNLSRAEVERYKNVMTSKIQQSDDAKNEYANQLQ 257
            ...|:.:||.:|:..:::|:|...:::.|.|:|:::|:||:.:.....:.|.:||:|.:|::.||
Frog   131 WKQLEASKRRFERDCKEAERAQQYFEKMDADINVTKADVEKARQQAQIRHQMADDSKGDYSSVLQ 195

  Fly   258 KTNNLQQQHYSMLLPSVLNRLQELDEKRTRGFREFIVGAADVESSVAPIIARCMEGIVKAGESIN 322
            |.|..|.:||...:|.:..:||:::||:.....|.:...||::..|.|||.:|::||.|:.|||:
Frog   196 KFNREQHEHYFTHIPGIFQKLQDMEEKKIGRMGESLKTYADIDRQVVPIIGKCLDGITKSAESIS 260

  Fly   323 EKEDTFKVIERYQSGFTPPRDIPFEDLSKCDPDSVQDS--------------------------- 360
            ||:|:..|||.::|||.||.||.|||.::....:|.|:
Frog   261 EKQDSQMVIESFKSGFEPPGDIDFEDFTQSMKRTVSDTSLTKADCKSDPKVPSKSRNKLWPFIKK 325

  Fly   361 ------------------HYSN-----------------------STSNHLTIRGTMSANKLKKR 384
                              |:||                       |:|......|..|..:.|:.
Frog   326 NKPAVYVTRYKHARFPAFHFSNWASGTWLMSLLTSPHQPPPPPPASSSPSAVPNGPHSPKQQKEP 390

  Fly   385 VG-IFNIFGSNK-----------------NSLTAD----------------------------GQ 403
            :. .||.|.::|                 .|:.||                            |.
Frog   391 LSHRFNDFMTSKPKMHCFRSLKRGPLQQTESVCADKGMMKRTIGKPTCAFEAREYVLSLKLCFGS 455

  Fly   404 K-----EDFSDLPPNQRRKKLQAKIAELTQNIAQETKARDGLMKMKIVYEANSSLGNPMTVEGQL 463
            :     ||||:|||.|||||||.|:.||.::|.:|...||.|.||:.||..|..:|:|.:|..:|
Frog   456 RQGSTPEDFSNLPPEQRRKKLQQKVDELNKDIQKEIDQRDALTKMRDVYMKNPQMGDPASVGQKL 520

  Fly   464 NESEHKLEKLKVDLKKYQGFL-EKASQVPTATSSPQASRNQLQNGHRTSRHSNGSADDHH----- 522
            .|..:.:|||:|::.|::|:| |...::|        :||.      :||..:|..|..:
Frog   521 VEIGNNIEKLRVEVHKFEGWLAEVEGRLP--------ARND------SSRRQSGLYDTQNTQTVN 571

  Fly   523 ---DDGDDQPDDAGSLSRSDSEDNVAQIQNGHNNNNNGSASPESGLGTSHTSLPGSGQGSANENA 584
               .|.:..||.      |.:|||              |..||  :..:.|..
Frog   572 NCAQDRESSPDG------SYTEDN--------------SQEPE--VKVTPTEF------------ 602

  Fly   585 IGEDTYYETEVETLNPVGKCRALYPFEASSEGSIPMSEGEELQVIEIDQGDGWTRVRRENNSNGW 649
               |..::.| |.|..:|.|:|:|||:..:||:|.::|||.|.|||.|:||||||:||:..
Frog   603 ---DDDFDDE-EPLPTIGTCKAIYPFDGENEGTISVTEGEILSVIEEDKGDGWTRIRRKEE---- 659

  Fly   650 DEGFVPTSYIEITL 663
            :||:|||||||:.|
Frog   660 EEGYVPTSYIEVYL 673

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cip4	NP_001097501.1	F-BAR_CIP4-like	69..319	CDD:153337	97/251 (39%)
		HR1_CIP4-like	412..488	CDD:212009	34/76 (45%)
		SH3_CIP4-like	603..661	CDD:212844	32/57 (56%)
fnbp1	XP_031746435.1	F-BAR_FBP17	5..257	CDD:153360	97/251 (39%)
		HR1_FBP17	469..545	CDD:212019	34/75 (45%)
		SH3_FBP17	616..672	CDD:213004	34/59 (58%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	247	1.000	Domainoid score	I2123
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D348563at2759
OrthoFinder	1	1.000	-	-		FOG0001169
OrthoInspector	1	1.000	-	-		otm47719
Panther	1	1.100	-	-	O	PTHR15735
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2056
SonicParanoid	1	1.000	-	-		X890
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	8	8.140