DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cip4 and ITSN1

DIOPT Version :9

Sequence 1:	NP_001097501.1	Gene:	Cip4 / 38534	FlyBaseID:	FBgn0035533	Length:	665	Species:	Drosophila melanogaster
Sequence 2:	NP_003015.2	Gene:	ITSN1 / 6453	HGNCID:	6183	Length:	1721	Species:	Homo sapiens

Alignment Length:	591	Identity:	110/591 - (18%)
Similarity:	196/591 - (33%)	Gaps:	195/591 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly   162 AGVTLLSKTLREER---KKCLSDGATLQQNLTTQL--SSLDRAKRNYEKAYRDSEK---AVDSYK 218
            :|::::|.|..::|   :..|.|.   ||.|..:|  :..|:.:.|:|:...:.||   |:...:
Human   315 SGISVISSTSVDQRLPEEPVLEDE---QQQLEKKLPVTFEDKKRENFERGNLELEKRRQALLEQQ 376

  Fly   219 RADMD--LNLSRAEVERYKNVMTSKIQQSDDAKNEYANQLQKTNNLQQQHYSMLLPSVLNRLQEL 281
            |.:.:  ..|.|||.||.:.   .:.:|....:.|...||:|...|::|.
Human   377 RKEQERLAQLERAEQERKER---ERQEQERKRQLELEKQLEKQRELERQR--------------- 423

  Fly   282 DEKRTRGFREFIVGAADVESSVAPIIARCMEGIVKAGESINEKEDTFKVIERYQSGFTPPRDIPF 346
            :|:|.:                                .|..:|...:.:||       .|.:.:
Human   424 EEERRK--------------------------------EIERREAAKRELER-------QRQLEW 449

  Fly   347 EDLSKCDPDSVQDSHYSNSTSNHLTIRGTMSAN----KLKKRVGIFNIFGSNKNSLTADGQKEDF 407
            |               .|.....|..|.....:    |.||:...|.:...|......:|:.:|.
Human   450 E---------------RNRRQELLNQRNKEQEDIVVLKAKKKTLEFELEALNDKKHQLEGKLQDI 499

  Fly   408 SDLPPNQRR------KKLQAKIAELT---------------------------QNIAQETKARDG 439
            ......||:      |..:.:|||:|                           :.:.|.:..||.
Human   500 RCRLTTQRQEIESTNKSRELRIAEITHLQQQLQESQQMLGRLIPEKQILNDQLKQVQQNSLHRDS 564

  Fly   440 LMKMKIVYEANSSLGNPMTVEGQLNESE--------------HKLEKLKVDLKKYQGFLEKASQV 490
            |:.:|...||.......:  ..||:|.|              ::|::|:....|.|...:|:.:.
Human   565 LVTLKRALEAKELARQHL--RDQLDEVEKETRSKLQEIDIFNNQLKELREIHNKQQLQKQKSMEA 627

  Fly   491 PTATSSPQASR-----NQLQNGHRTSRHSNGSADDH--HDDGDDQP-----------------DD 531
            .......|..:     .|.:...|.::..:....:|  .:|...:|                 .|
Human   628 ERLKQKEQERKIIELEKQKEEAQRRAQERDKQWLEHVQQEDEHQRPRKLHEEEKLKREESVKKKD 692

  Fly   532 AGSLSRSDSEDNVAQIQNGHNNNNNGSASPESGLGTSHTSLPGSGQGSANENAIGEDTYYETEVE 596
            .....:.:::|.:.::.:.|..    .|.|......| |:..|....||.||.  :..||
Human   693 GEEKGKQEAQDKLGRLFHQHQE----PAKPAVQAPWS-TAEKGPLTISAQENV--KVVYY----- 745

  Fly   597 TLNPVGKCRALYPFEASSEGSIPMSEGEELQVIEIDQGDGWTRVRRENNSNGW-------DEGFV 654
                    |||||||:.|...|.:..|:.:.|    :|: |.. ..:....||       ..|:.
Human   746 --------RALYPFESRSHDEITIQPGDIVMV----KGE-WVD-ESQTGEPGWLGGELKGKTGWF 796

  Fly   655 PTSYIE 660
            |.:|.|
Human   797 PANYAE 802

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cip4	NP_001097501.1	F-BAR_CIP4-like	69..319	CDD:153337	32/166 (19%)
		HR1_CIP4-like	412..488	CDD:212009	23/122 (19%)
		SH3_CIP4-like	603..661	CDD:212844	19/65 (29%)
ITSN1	NP_003015.2	EH	14..108	CDD:197477
		EH	26..90	CDD:238009
		EH	214..309	CDD:197477
		EH	225..291	CDD:238009
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	322..348		8/28 (29%)
		KLERQ	326..702		75/452 (17%)
		GBP_C	<331..414	CDD:303769	22/88 (25%)
		COG1340	372..686	CDD:224259	61/387 (16%)
		coiled coil	383..394	CDD:293879	5/10 (50%)
		coiled coil	403..414	CDD:293879	2/10 (20%)
		AAA_23	<509..636	CDD:290211	21/128 (16%)
		GBP_C	<616..686	CDD:303769	9/69 (13%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	650..701		5/50 (10%)
		SH3_Intersectin1_1	744..803	CDD:212920	21/78 (27%)
		INTAP	803..917	CDD:293223	110/591 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	836..868
		SH3_Intersectin1_2	917..968	CDD:212922
		SH3_Intersectin1_3	1006..1057	CDD:212924
		SH3_Intersectin1_4	1074..1138	CDD:212926
		Required for interaction with FCHSD2. /evidence=ECO:0000269\|PubMed:29887380	1074..1138
		Bipartite nuclear localization signal, in isoform 2. /evidence=ECO:0000269\|PubMed:29599122	1104..1127
		SH3_Intersectin1_5	1158..1211	CDD:212928
		RhoGEF	1242..1422	CDD:279015
		PH_ITSN	1448..1579	CDD:270084
		PH	1465..1571	CDD:278594
		C2_Intersectin	1582..1716	CDD:176021
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2056
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.030