Protein Alignment Cip4 and srgap3

DIOPT Version :10

• Sequence 1: NP_001097501.1
• Gene: Cip4 / 38534
• FlyBaseID: FBgn0035533
• Length: 665
• Species: Drosophila melanogaster
• Sequence 2: XP_005166172.1
• Gene: srgap3 / 561567
• ZFINID: ZDB-GENE-060524-4
• Length: 1094
• Species: Danio rerio
• Alignment Length: 810
• Identity: 150/810 - (18%)
• Similarity: 268/810 - (33%)
• Gaps: 230/810 - (28%)

  Fly    52 LAESENSAQNSNNMSWGTELWDQNENLAIHTNRGIDALDKFANFLRDRVAIETEYAGKLRRLVKN 116
            :||.|...:...|     :|.:|.:.|...:...|..|.....|.|.:..|:.||:..|.:|.:.
Zfish    14 IAEYETQVKEIRN-----QLVEQFKCLEQQSEARIQLLQDLQEFFRRKAEIQLEYSRSLEKLAER 73

  Fly   117 YQPKKK--EEEDNEFTSVQAFRNLLKEVGDLAGQREVVSESLQLQIIAGVTLLSKTLREERKKCL 179
            :..|.:  .:|.:..:||..:..:|.:....:.....:::.....:|..:..:|:.:....||..
Zfish    74 FSSKIRGPRKEQHLLSSVNCWYLVLNQTRRESRDHATLNDIYINNVIVRLAQISEDVIRLFKKSK 138

  Fly   180 SDGATLQQNLTTQLSSLDRAKRNY----------EKAYRDSEKAVDSY--KRADMDLNLSRAE-- 230
            ..|..:.:.|....:.|....:.|          |...:|:||..:..  |..|:::||.|.|
Zfish   139 EIGIQMHEELVKVTNELYTVMKTYHMYHTESISAESKLKDAEKQEEKQFSKSGDLNVNLLRHEDR 203

  Fly   231 ---------VERYKNVMTSKIQQS----DDAKNEYANQLQKTNNLQQQHYSMLLPSVLNRLQELD 282
                     :|:.|....:|..::    ..|:|:|...|..||.:..::|   :..|.:.:...|
Zfish   204 PQRRSSVRKIEKMKEKRQAKYSENKLKCTKARNDYLLNLAATNAVVAKYY---IHDVSDMIDCCD 265

  Fly   283 ----EKRTRGFREFIVGAADVESSVAPIIARCMEG---IVKAGESINEKEDTFKVIERYQSGFTP 340
                ....|..|.::....::|:|       ..||   |..|.::::.:.|..|:::.|...|.|
Zfish   266 LGYHASLARTLRTYLSAEYNLETS-------RHEGLDIIENAVDNLDPRSDKHKIMDMYNQVFCP 323

  Fly   341 PRDIPFEDLSKCDPDSVQDS-------------HYSNSTSNHL---------TIRGTMSANKLKK 383
            |  :.||.|.....:..|.|             |...|....|         |:..||...:...
Zfish   324 P--MRFEFLPHMGDEVCQVSAQQPVQTELLMRFHQLQSRLATLKIENEEVRKTLDATMQTLQDML 386

  Fly   384 RVGIFNIFGSNKNSLTADGQK----EDF-SDLPPNQRRK------------------------KL 419
            .|..|::..:.::|.:.:..|    |.: |.|...:||.                        ||
Zfish   387 TVEDFDVSDAFQHSRSTESIKSVASESYMSKLNIAKRRANQQETEVFYFTKFKEYLNGSNLIIKL 451

  Fly   420 QAKIAELTQNIAQETKARDGLM---------------KMKIVYEANSSLGN------------PM 457
            |||...|.|.:.:..:|..|..               :.:.||......||            |:
Zfish   452 QAKHDLLKQTLGEGERAECGTTRPPTLPPKPQKLRKPRPRSVYNHKLFNGNMESFIKDSGQAIPL 516

  Fly   458 TVEGQL---------------------------------------NESEHKLEKLKVDLKKY--- 480
            .||..:                                       ::|:|.:..:...||.|
Zfish   517 VVESCIRYINLYGLQQQGIFRVPGSQVEVNDIKNSFERGEDPLVDDQSDHDINSVAGVLKLYFRG 581

  Fly   481 --------QGFLEKASQVPTATSSPQASRNQ-------------LQNGHRTSRHSNGSADDHHDD 524
                    :.||:..|.|...:|:.:|...|             |:.......|.:..:|::..|
Zfish   582 LENPLFPKERFLDMISTVKLESSAERAHHIQQIIVTLPRTVIIVLRYLFAFLNHLSQYSDENMMD 646

  Fly   525 GDDQPDDAGS--LSRSDSEDNVAQIQNGHNN---------NNNGSASPE-----------SGLGT 567
            ..:.....|.  :...|.:|.||  ...|.|         |.....||.           :| |.
Zfish   647 PYNLAICFGPTLMPIPDGQDPVA--CQAHVNEVIKTIIMHNEIIFPSPRELDGPVYEKCMTG-GE 708

  Fly   568 SHTSLPGSGQGSANE-NAIGEDTYYETEVETLNPVGKCRALYPFEASSEGSIPMSEGEELQVIEI 631
            .:...|.|..|:.:| :...|....:.|||.:..:.|    :.:...:...:...:|..|.:...
Zfish   709 EYCDSPHSEPGTIDEADNCTEPHTSDDEVEQIEAIAK----FDYMGRTPRELSFKKGASLLLYHR 769

  Fly   632 DQGDGWTRVRRENNSNGWDEGFVPTSYIEI 661
            ...|.|     |...||.| |.:|..||.:
Zfish   770 ASEDWW-----EGRHNGVD-GLIPHQYIVV 793

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cip4	NP_001097501.1	F-BAR_CIP4-like	69..319	CDD:153337	55/285 (19%)
		HR1_CIP4-like	412..488	CDD:212009	25/176 (14%)
		SH3_CIP4-like	603..661	CDD:212844	13/57 (23%)
srgap3	XP_005166172.1	BAR	26..273	CDD:472257	48/254 (19%)
		RhoGAP_srGAP	497..684	CDD:239848	28/188 (15%)
		SH3_srGAP1-3	741..793	CDD:212888	13/61 (21%)