DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cip4 and arhgap4b

DIOPT Version :9

Sequence 1:	NP_001097501.1	Gene:	Cip4 / 38534	FlyBaseID:	FBgn0035533	Length:	665	Species:	Drosophila melanogaster
Sequence 2:	XP_689729.3	Gene:	arhgap4b / 561231	ZFINID:	ZDB-GENE-090311-38	Length:	966	Species:	Danio rerio

Alignment Length:	833	Identity:	154/833 - (18%)
Similarity:	255/833 - (30%)	Gaps:	272/833 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly    39 LASGSSRSSSNNKLAESENSAQNSNNMSWGTELWDQNENLAIHTNRGIDALDKFANFLRDRVAIE 103
            :.|..........|||.|...:....     :|.:|.:.|..........|...:.:||.|..||
Zfish     1 MTSHGKLRKEKGSLAEYETQIKEVRG-----QLSEQLKILDAQLEVKTQQLQDMSEYLRRRGEIE 60

  Fly   104 TEYAGKLRRLVKNYQPKKKEEEDNEFTSVQAFRNLLKEVGDLAGQREVVSESLQLQIIAGVTLLS 168
            .|||..|.:|.:.:..|.|.:|..:.:..|.:..||.:....:.....:||           |..
Zfish    61 AEYARSLEKLSEKFTVKTKRKEQLDLSVAQCWSVLLTQTRQESRDHSSLSE-----------LCG 114

  Fly   169 KTLREERKKCLSD-----------GATLQQNLTTQLSSLDRAKRNYEKAYRDSEKAVDSYKRA-- 220
            .||.:....|:.|           |..:|..|....:.|..|.:.|.:.:.|...|....|.|
Zfish   115 NTLTQRLSHCIEDTHRLAKRSKEVGLQMQDELLKITTELQTALKTYHQYHIDCLAAEGKLKEATR 179

  Fly   221 --------DMDLNLS------RAEVERYKNVM---TSKIQQSD----DAKNEYANQLQKTNNLQQ 264
                    ..||.||      |:.|::.:.:|   ..|:|::.    .|:|:|...|...|....
Zfish   180 LEEKQTGKSADLGLSQSGGQRRSSVKKMERLMEKRQGKVQETQLKCTKARNDYLLNLAAANASMN 244

  Fly   265 QHY------------------------------SMLLPSVLNRLQELDEKRTRGFREFIVGAADV 299
            ::|                              :.::.::.|.||:||...| |..:    ..|.
Zfish   245 KYYLQDICTLIDCTDLGYHLSVTRVIRGYLSYKNRIVQNMKNGLQQLDTAVT-GLNQ----GQDR 304

  Fly   300 ESSV-APIIARCM---------EG-----IVKAGESINEKEDTFKVIERYQSGFTPPRDIPFEDL 349
            :|.: |..||.|:         ||     :...|:...|.:..|:.::...:..|...|...:.|
Zfish   305 DSLLQAHNIAFCLPFRFQYQPHEGDQVCEVSAEGQVRYELDTRFQQLQSRLASVTLETDEVSKTL 369

  Fly   350 ---------SKCDPDSVQDSHYSNSTSNHLTIRGTMSANKLKKR------VGIF-------NIFG 392
                     |.||.|.......|::.|...|..||.:...|.||      ...|       ::.|
Zfish   370 KATHSNLLESVCDDDCNPAPDASSTPSVEGTADGTGTKPSLAKRRANQQDTETFYFTKVKEHVSG 434

  Fly   393 SN-------KNSLTADG-QKEDFSDLPPNQRRKKLQAKIAELTQNIAQETKARDGLMKMKIVYEA 449
            |:       |:.|..:. ||.:..|..|::.:.....::.:.........|...|.| :..:..:
Zfish   435 SSLISKLQAKHDLLKEAIQKAEAIDSDPSRMQPGRAVRVRKARPCSQYNHKLFSGDM-LSFIQSS 498

  Fly   450 NSSLGNPMTVEG-------------------------------------QLNESEHKLEKLKVDL 477
            ...:  |:.||.                                     .|.:||..::.:...|
Zfish   499 GQQI--PLVVESCIRFINLHGLHHEGIFRVPGSQTEVNHIRDAFERGEDPLTDSESDIDSVAGVL 561

  Fly   478 KKY-----------------------QGFLEKASQVPTATSS-PQ----ASRNQLQNGHRTSRHS 514
            |.|                       :...||.:|:.:..|| |:    ..|......|..|::|
Zfish   562 KLYFRGLEKPLFPEESFSQLMECVQMENMTEKVAQIKSVVSSYPRPVIIVMRYLFAFLHHVSQYS 626

  Fly   515 NGSADDHHDDGDDQPDDAG-----SLSR-----SDSEDNVAQIQN-------GHNNNNNGSASPE 562
                    |:...||.:..     ||.|     .|......||..       .|.|...|.
Zfish   627 --------DENMMQPYNLAVCFGPSLLRGVEMGGDEVTLAPQINELVKTMILHHENIFPGP---- 679

  Fly   563 SGLGTSHTSLPG-------------------SGQGSANENAIGEDTYYETEVETLNPVGKCRALY 608
                   :.|||                   .|:|.. |:...||.:            :..|::
Zfish   680 -------SELPGPVYEKCMTLEQEYCEPITEEGEGDP-EHLPSEDEW------------EAVAMF 724

  Fly   609 PFEASSEGSIPMSEGEELQVIEIDQGDGWTRVRRENNSNGWDEGFVPTSYIEI 661
            .:.|.|...:...:||.|.:......|.|      ....|..:|.:|..||.:
Zfish   725 DYVARSAAELSFKQGEHLLLHSKASADWW------RGEVGGMKGLIPHKYISV 771

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cip4	NP_001097501.1	F-BAR_CIP4-like	69..319	CDD:153337	67/328 (20%)
		HR1_CIP4-like	412..488	CDD:212009	15/135 (11%)
		SH3_CIP4-like	603..661	CDD:212844	13/57 (23%)
arhgap4b	XP_689729.3	F-BAR_srGAP	27..266	CDD:153340	52/249 (21%)
		RhoGAP_srGAP	485..671	CDD:239848	31/196 (16%)
		SH3	717..771	CDD:302595	13/71 (18%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910