Protein Alignment Cip4 and arhgap4b

DIOPT Version :10

• Sequence 1: NP_001097501.1
• Gene: Cip4 / 38534
• FlyBaseID: FBgn0035533
• Length: 665
• Species: Drosophila melanogaster
• Sequence 2: XP_689729.3
• Gene: arhgap4b / 561231
• ZFINID: ZDB-GENE-090311-38
• Length: 966
• Species: Danio rerio
• Alignment Length: 833
• Identity: 154/833 - (18%)
• Similarity: 255/833 - (30%)
• Gaps: 272/833 - (32%)

  Fly    39 LASGSSRSSSNNKLAESENSAQNSNNMSWGTELWDQNENLAIHTNRGIDALDKFANFLRDRVAIE 103
            :.|..........|||.|...:....     :|.:|.:.|..........|...:.:||.|..||
Zfish     1 MTSHGKLRKEKGSLAEYETQIKEVRG-----QLSEQLKILDAQLEVKTQQLQDMSEYLRRRGEIE 60

  Fly   104 TEYAGKLRRLVKNYQPKKKEEEDNEFTSVQAFRNLLKEVGDLAGQREVVSESLQLQIIAGVTLLS 168
            .|||..|.:|.:.:..|.|.:|..:.:..|.:..||.:....:.....:||           |..
Zfish    61 AEYARSLEKLSEKFTVKTKRKEQLDLSVAQCWSVLLTQTRQESRDHSSLSE-----------LCG 114

  Fly   169 KTLREERKKCLSD-----------GATLQQNLTTQLSSLDRAKRNYEKAYRDSEKAVDSYKRA-- 220
            .||.:....|:.|           |..:|..|....:.|..|.:.|.:.:.|...|....|.|
Zfish   115 NTLTQRLSHCIEDTHRLAKRSKEVGLQMQDELLKITTELQTALKTYHQYHIDCLAAEGKLKEATR 179

  Fly   221 --------DMDLNLS------RAEVERYKNVM---TSKIQQSD----DAKNEYANQLQKTNNLQQ 264
                    ..||.||      |:.|::.:.:|   ..|:|::.    .|:|:|...|...|....
Zfish   180 LEEKQTGKSADLGLSQSGGQRRSSVKKMERLMEKRQGKVQETQLKCTKARNDYLLNLAAANASMN 244

  Fly   265 QHY------------------------------SMLLPSVLNRLQELDEKRTRGFREFIVGAADV 299
            ::|                              :.::.::.|.||:||...| |..:    ..|.
Zfish   245 KYYLQDICTLIDCTDLGYHLSVTRVIRGYLSYKNRIVQNMKNGLQQLDTAVT-GLNQ----GQDR 304

  Fly   300 ESSV-APIIARCM---------EG-----IVKAGESINEKEDTFKVIERYQSGFTPPRDIPFEDL 349
            :|.: |..||.|:         ||     :...|:...|.:..|:.::...:..|...|...:.|
Zfish   305 DSLLQAHNIAFCLPFRFQYQPHEGDQVCEVSAEGQVRYELDTRFQQLQSRLASVTLETDEVSKTL 369

  Fly   350 ---------SKCDPDSVQDSHYSNSTSNHLTIRGTMSANKLKKR------VGIF-------NIFG 392
                     |.||.|.......|::.|...|..||.:...|.||      ...|       ::.|
Zfish   370 KATHSNLLESVCDDDCNPAPDASSTPSVEGTADGTGTKPSLAKRRANQQDTETFYFTKVKEHVSG 434

  Fly   393 SN-------KNSLTADG-QKEDFSDLPPNQRRKKLQAKIAELTQNIAQETKARDGLMKMKIVYEA 449
            |:       |:.|..:. ||.:..|..|::.:.....::.:.........|...|.| :..:..:
Zfish   435 SSLISKLQAKHDLLKEAIQKAEAIDSDPSRMQPGRAVRVRKARPCSQYNHKLFSGDM-LSFIQSS 498

  Fly   450 NSSLGNPMTVEG-------------------------------------QLNESEHKLEKLKVDL 477
            ...:  |:.||.                                     .|.:||..::.:...|
Zfish   499 GQQI--PLVVESCIRFINLHGLHHEGIFRVPGSQTEVNHIRDAFERGEDPLTDSESDIDSVAGVL 561

  Fly   478 KKY-----------------------QGFLEKASQVPTATSS-PQ----ASRNQLQNGHRTSRHS 514
            |.|                       :...||.:|:.:..|| |:    ..|......|..|::|
Zfish   562 KLYFRGLEKPLFPEESFSQLMECVQMENMTEKVAQIKSVVSSYPRPVIIVMRYLFAFLHHVSQYS 626

  Fly   515 NGSADDHHDDGDDQPDDAG-----SLSR-----SDSEDNVAQIQN-------GHNNNNNGSASPE 562
                    |:...||.:..     ||.|     .|......||..       .|.|...|.
Zfish   627 --------DENMMQPYNLAVCFGPSLLRGVEMGGDEVTLAPQINELVKTMILHHENIFPGP---- 679

  Fly   563 SGLGTSHTSLPG-------------------SGQGSANENAIGEDTYYETEVETLNPVGKCRALY 608
                   :.|||                   .|:|.. |:...||.:            :..|::
Zfish   680 -------SELPGPVYEKCMTLEQEYCEPITEEGEGDP-EHLPSEDEW------------EAVAMF 724

  Fly   609 PFEASSEGSIPMSEGEELQVIEIDQGDGWTRVRRENNSNGWDEGFVPTSYIEI 661
            .:.|.|...:...:||.|.:......|.|      ....|..:|.:|..||.:
Zfish   725 DYVARSAAELSFKQGEHLLLHSKASADWW------RGEVGGMKGLIPHKYISV 771

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cip4	NP_001097501.1	F-BAR_CIP4-like	69..319	CDD:153337	67/328 (20%)
		HR1_CIP4-like	412..488	CDD:212009	15/135 (11%)
		SH3_CIP4-like	603..661	CDD:212844	13/57 (23%)
arhgap4b	XP_689729.3	F-BAR_srGAP	27..266	CDD:153340	52/249 (21%)
		RhoGAP_srGAP	485..671	CDD:239848	31/196 (16%)
		SH3	717..771	CDD:473055	13/71 (18%)