Protein Alignment Cip4 and srgap1b

DIOPT Version :10

• Sequence 1: NP_001097501.1
• Gene: Cip4 / 38534
• FlyBaseID: FBgn0035533
• Length: 665
• Species: Drosophila melanogaster
• Sequence 2: XP_005164640.1
• Gene: srgap1b / 555788
• ZFINID: ZDB-GENE-041210-103
• Length: 1071
• Species: Danio rerio
• Alignment Length: 823
• Identity: 157/823 - (19%)
• Similarity: 286/823 - (34%)
• Gaps: 252/823 - (30%)

  Fly    41 SGSSRSSSNNK-LAESENSAQNSNNMSWGTELWDQNENLAIHTNRGIDALDKFANFLRDRVAIET 104
            |.|::|....: :.|.|:..:...     ::|.:|.:.|...|:..:..|....:|.|.:..||:
Zfish     2 SNSTKSKKEKEIITEYESQVKEIR-----SQLVEQQKCLEQQTDMRVQLLQDLQDFFRKKAEIES 61

  Fly   105 EYAGKLRRLVKNYQPKKKEEED--------NEFTSVQAFRNLLKEVGDLAGQREVVSESLQLQII 161
            ||:..|.:|.:.:..|.:..:|        |..:.|..:..||.:|...:.....:|:.....:|
Zfish    62 EYSRNLEKLAERFMAKTRSTKDHQQYKKDQNLLSPVNCWYLLLNQVRRESKDHATLSDLYLNNVI 126

  Fly   162 AGVT--------LLSKT------LREERKKCLSDGATLQQNL----TTQLSS---LDRAKRNYEK 205
            ...|        ||.|:      |:|:..|.|::..|:.:..    |..||:   |..|:|..|:
Zfish   127 TRFTHVSEDNMRLLKKSKEIIFQLQEDLMKILNELYTVMKTYHMYHTETLSAENKLKEAERQGER 191

  Fly   206 AYRDSEKAVDSYKRADMDLNLSRA-EVERYKNVMTSKIQQSD----DAKNEYANQLQKTNNLQQQ 265
            ..|..| ||.|.:..|.....:.| ::::.|....:|..::.    .|:|||...|:.||....:
Zfish   192 QGRGGE-AVFSLRTEDRHQRRNAARKIQKMKEKRQAKYSENKLKVMKARNEYLLTLEATNASLFK 255

  Fly   266 HYSMLLPSVLNRLQELDE--------KRTRGFREFIVGAADVESSVAPIIAR-----CMEGIVKA 317
            :|       ::.|..|.:        ..:|..|.::.....:|:|      |     .:||.|
Zfish   256 YY-------IHDLSHLTDCCDLGYHAGLSRALRTYLSAEYSLETS------RHEGLDILEGAV-- 305

  Fly   318 GESINEKEDTFKVIERYQSGFTPPRDIPF-----EDLSKCDP-DSVQ----------DSHYSNST 366
             |.::...|..:.:|.:.:.||||....|     :.:|:... ..||          .|..|...
Zfish   306 -EGLDPGNDRQRFMETHPTSFTPPTRFTFQPHMGDQVSQITALPQVQAELLLRFQQLQSRLSTLK 369

  Fly   367 SNHLTIRGTMSA--NKLKKRVGI--FNIFGSNKNSLTADGQKEDFSDL----PPNQRRK------ 417
            ..:..::.|..|  :.::..|.:  :::..|.::|.:.:..|...||.    |...:|:
Zfish   370 IENEEVKKTSEATLSTIQDMVNMEDYDVSESFQHSRSTESVKSSVSDTYLSKPSLAKRRANQQET 434

  Fly   418 -------------------KLQAKIAELTQNIAQETKA---------------RDGLMKMKIVYE 448
                               |||||...|.::||:..:|               :|....:.::.|
Zfish   435 ELFYFTKLKEYLEGSNLIAKLQAKHDMLKRSIAEGYRADIMTTSRRRNSHSRNQDSGKAIPLIVE 499

  Fly   449 A-----------------------------NS-SLGN-PMTVEGQLNESEHKLEKLKVDLKKY-- 480
            :                             || ..|| |:|.|    |:.|.:..:...||.|
Zfish   500 SCIRFINLYGLQHQGIFRVSGSQVEVNDIKNSFERGNDPLTDE----ENNHDINSVAGVLKMYFR 560

  Fly   481 ---------------------QGFLEKASQV-PTATSSPQ----------ASRNQLQNGHRTSRH 513
                                 :...|:|..: ...|:.|:          |..|.|      |::
Zfish   561 NLDNPIFPKEKFNDLIACVRTESLYERALSIRKILTTMPRPTLVLMRYLFAFLNHL------SQY 619

  Fly   514 SNGSADDHHDDGDDQPDDAGSL------SRSDSEDNVAQIQ-NGHNNN-------NNGSASPESG 564
            |           |:...|.|:|      :...:.|.:.|:. ..|.|.       ::.:..|::.
Zfish   620 S-----------DENMMDPGNLAICFGPTLMPTPDLLDQVSCQAHVNEIVKTIIIHHETIFPDTK 673

  Fly   565 -----------LGTSHTSLPGSGQGSANENAIGEDTYYETEVETLNPVGKCRALYPFEASSEGSI 618
                       ..|.:...|.|..|:..|......|..:|..|...|| :..|.:.:...|...:
Zfish   674 ELEGPVYEKCMSNTEYCESPYSEPGAFEEGEQDGGTETQTSEEEGEPV-EAIAKFDYVGRSGREL 737

  Fly   619 PMSEGEELQVIEIDQGDGWTRVRRENNSNGWDEGFVPTSYIEI 661
            ...:|..|.:.:....|.|     |...||.| |.:|..|:.:
Zfish   738 TFKKGSTLLLFQRASEDWW-----EGRHNGTD-GLIPHQYVTL 774

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cip4	NP_001097501.1	F-BAR_CIP4-like	69..319	CDD:153337	65/296 (22%)
		HR1_CIP4-like	412..488	CDD:212009	25/169 (15%)
		SH3_CIP4-like	603..661	CDD:212844	13/57 (23%)
srgap1b	XP_005164640.1	BAR	26..277	CDD:472257	57/258 (22%)
		RhoGAP_srGAP	480..664	CDD:239848	31/204 (15%)
		SH3	722..772	CDD:473055	12/55 (22%)