DRSC/TRiP Functional Genomics Resources

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Protein Alignment Cip4 and ITSN2

DIOPT Version :9

Sequence 1:NP_001097501.1 Gene:Cip4 / 38534 FlyBaseID:FBgn0035533 Length:665 Species:Drosophila melanogaster
Sequence 2:NP_006268.2 Gene:ITSN2 / 50618 HGNCID:6184 Length:1697 Species:Homo sapiens


Alignment Length:637 Identity:124/637 - (19%)
Similarity:221/637 - (34%) Gaps:186/637 - (29%)


- Green bases have known domain annotations that are detailed below.


  Fly   105 EYAGKLRRLVKNYQPKKKEEE------DNEFTSVQAFRNLLKEVGD----LAGQREVVSESLQ-L 158
            :.:|:|:.:....|.:|.|.|      |.|...::..:..|:|..:    |..::::::|.:: :
Human   504 QISGRLQDVRLKKQTQKTELEVLDKQCDLEIMEIKQLQQELQEYQNKLIYLVPEKQLLNERIKNM 568

  Fly   159 QII----AGVTLLSKTLREERKKCLSDGATLQQNLTTQLSSLDRAKRNYEKAYRDSEKAVDSY-- 217
            |..    :||:||.|...|:.:.|        |.|..||.:|::     |.|.:.||  :||:  
Human   569 QFSNTPDSGVSLLHKKSLEKEELC--------QRLKEQLDALEK-----ETASKLSE--MDSFNN 618

  Fly   218 --KRADMDLNLSRAEVERYKNVMTSKIQQSDDAKNEY--ANQLQKTNNLQQQHYSMLLPSVLNRL 278
              |..:||           .:|:...:.......|.:  ..:|::|.|.||.....|.....::|
Human   619 QLKCGNMD-----------DSVLQCLLSLLSCLNNLFLLLKELRETYNTQQLALEQLYKIKRDKL 672

  Fly   279 QELDEKRTRGFREFIVGAADVESSVAPIIARCMEGIVKAGESINEKEDTFKVIERYQSGFTPPRD 343
            :|::.||..     ::....:|...|....:..|.:.|......|:|...::.|..........:
Human   673 KEIERKRLE-----LMQKKKLEDEAARKAKQGKENLWKENLRKEEEEKQKRLQEEKTQEKIQEEE 732

  Fly   344 IPFEDLSKCDPDSVQDSHYSNSTS---------------NHLTIRGTMSANK------LKKRVG- 386
            ...|:..:.|.|:::.......|:               ||    ..||.|.      .:|.|| 
Human   733 RKAEEKQRKDKDTLKAEEKKRETASVLVNYRALYPFEARNH----DEMSFNSGDIIQVDEKTVGE 793

  Fly   387 ---IFNIFGSNKNSLTADGQKEDFSDLPPNQRRKKLQAKIAEL--TQNIAQETKARDGLMKMKIV 446
               ::..|..|......:..::    :|.::..|.:..|.|.|  |.:::..:.:.:.|      
Human   794 PGWLYGSFQGNFGWFPCNYVEK----MPSSENEKAVSPKKALLPPTVSLSATSTSSEPL------ 848

  Fly   447 YEANSSLGNPMTVEGQLNESEHKLEKLKVDLKKYQGFLEKASQVPTATSSPQASRNQLQNGHRTS 511
                 |...|.:|....|.|...| .:....:|...|        |.|.||              
Human   849 -----SSNQPASVTDYQNVSFSNL-TVNTSWQKKSAF--------TRTVSP-------------- 885

  Fly   512 RHSNGSADDHHDDGD--------------DQPDDAGSLSRSDSEDNVAQIQN---GHNNNNNG-- 557
                ||....|..|.              .:.|:..:.|:.|....:.|.:|   |..:...|  
Human   886 ----GSVSPIHGQGQVVENLKAQALCSWTAKKDNHLNFSKHDIITVLEQQENWWFGEVHGGRGWF 946

  Fly   558 --------------SASPESGLGTSHTSLPGSGQGSANENAIGEDTYYETEVETLNPVGKCRALY 608
                          ...||: |..:....|.|...|..|..|                    |||
Human   947 PKSYVKIIPGSEVKREEPEA-LYAAVNKKPTSAAYSVGEEYI--------------------ALY 990

  Fly   609 PFEASSEGSIPMSEGEELQVIEIDQGDGWTRVRRENNSNGWDEGFVPTSYIE 660
            |:.:...|.:..:||||:.|.:.| |:.||      .|.|...|..|::|::
Human   991 PYSSVEPGDLTFTEGEEILVTQKD-GEWWT------GSIGDRSGIFPSNYVK 1035

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Cip4NP_001097501.1 F-BAR_CIP4-like 69..319 CDD:153337 50/234 (21%)
HR1_CIP4-like 412..488 CDD:212009 14/77 (18%)
SH3_CIP4-like 603..661 CDD:212844 19/58 (33%)
ITSN2NP_006268.2 SH3_Intersectin2_4 1057..1115 CDD:212927
SH3_Intersectin2_5 1130..1183 CDD:212929
RhoGEF 1214..1394 CDD:214619
PH_13 1412..1554 CDD:318790
C2_Intersectin 1555..1689 CDD:176021
EH 15..107 CDD:197477
SOBP <90..182 CDD:317654
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 219..241
EH 237..316 CDD:197477
Neuromodulin_N <346..756 CDD:331332 56/282 (20%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 350..378
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 691..752 9/60 (15%)
SH3_Intersectin2_1 759..815 CDD:212921 10/59 (17%)
INTAP 815..902 CDD:318758 23/128 (18%)
SH3_Intersectin2_2 902..953 CDD:212923 7/50 (14%)
SH3_Intersectin2_3 985..1036 CDD:212925 20/78 (26%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R2056
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
11.030

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