Protein Alignment Cip4 and arhgap4a

DIOPT Version :10

• Sequence 1: NP_001097501.1
• Gene: Cip4 / 38534
• FlyBaseID: FBgn0035533
• Length: 665
• Species: Drosophila melanogaster
• Sequence 2: NP_956738.2
• Gene: arhgap4a / 393416
• ZFINID: ZDB-GENE-040426-1229
• Length: 917
• Species: Danio rerio
• Alignment Length: 773
• Identity: 135/773 - (17%)
• Similarity: 239/773 - (30%)
• Gaps: 270/773 - (34%)

  Fly    94 NFLRDRVAIETEYAGKLRRLVKNYQPKKKEEEDNEFTSVQAFRNLLKEVGDLAGQREVVSES--- 155
            ::||.|..||.|||..|.:|...:..:.|::|.:..:.|..::.||.:....:....::|:|
Zfish    51 DYLRRRGEIEGEYARSLDKLCDKFSSRTKKKESSHQSVVNCWQVLLAQTRQESRDHSILSDSYSN 115

  Fly   156 -LQLQIIAGVTLLSKTLREERKKC--LSDGATLQQNLTTQLSSLDRAKRNYEKAYRDSE-KAVDS 216
             |..|:...:....:..:..|:.|  |.||..   .:|.:|.:..:....|...:..:| |..::
Zfish   116 ILPQQLSHCIEHAQRLAKRSREICTLLQDGLL---KVTIELHTTLKTYYQYYTEFLSAEGKLKEA 177

  Fly   217 YKRADMDLNLSRAEVERYKNVMTSKIQQ----SDDAKNEYANQLQKTNNLQQQHY---------- 267
            .|..:.....:..::||.......|:|:    ...|:|:|...|...|....::|
Zfish   178 VKLEEKQKQSASKKMERQIEKRQCKVQEIQLKCTKARNDYLLNLAAANACMNKYYLQDLSTLIDC 242

  Fly   268 ---------SMLLPSVLNRLQELDEKRTRGFREFIVGAADVESS--------------------- 302
                     |.:|...|:..|...:..:.|.|:.....:::..|
Zfish   243 CDLGYHQSISKVLHFYLSSRQWAQQNLSTGMRQLETTVSELSQSQDRDTLMQFNNSAFCLPLRFQ 307

  Fly   303 --------VAPIIARC--MEGIVKAGESIN--------EKEDTFKVIERYQS-----------GF 338
                    |..:.|:|  |..:|...:.:.        |.|::.|:::..||           |.
Zfish   308 YHPYEGDQVVEVSAKCEMMSELVTRVQQLQSRLSSVTLEVEESGKLLQSAQSSILESLAEIAFGS 372

  Fly   339 TPPRDIPFEDLSKCDPDSVQD---------------------------SHYSNST---------- 366
            ||  |.|   .|...|:...|                           .|..||:
Zfish   373 TP--DFP---SSPSSPEGNSDVSANKNFTLKRRASLPDAESLYFTKVRDHLCNSSLRSKLEAKHD 432

  Fly   367 -------------SNHLTIRGTMSANKLKKRVG------IFNIFGSNKNSLTADGQ--------- 403
                         .||...|...|....|...|      :||  |...:.:.|.||
Zfish   433 LLKVAIQKAESFDGNHTRTRSKRSVRHKKSNPGSQINQKLFN--GDLLSYIQASGQLIPAVVESC 495

  Fly   404 ---------------KEDFSDLPPNQRRKKLQAKIAELT-QNIAQETKARDGLMKMKIVYEANSS 452
                           :...|.:..||.:...:.....|| :....::.|  |::|:..     ..
Zfish   496 IRFINLNGLHHEGLFRVPGSQMVVNQLKDAFEKGDDPLTDERCDMDSVA--GVLKLYF-----RG 553

  Fly   453 LGNPMTVE---------GQLNESEHKLEKLKVDLKKYQ-----------GFLEKASQVPTATSSP 497
            |..|:..|         ||:::...|:.:||:.:..|.           .||
Zfish   554 LEKPLFPEDSYDQLMECGQIDDETKKVTQLKLIVSSYPPSLIIVMRYLFAFL------------- 605

  Fly   498 QASRNQLQNGHRTSRHSNGSADDHHDDGDDQPDDAG-----SLSRSDSEDNVAQIQNGHNNNNNG 557
                      |..|::|        |:...||.:..     ||.|..:..:.|::|..:....:.
Zfish   606 ----------HHVSQYS--------DENMMQPYNLAVCFGPSLVRGPNNGDAAELQRINALVKSI 652

  Fly   558 SASPESGLGTSHTSLPG-------------------SGQGSANENAIGEDTYYETEVETLNPVGK 603
            ....|| :..|...|||                   .|.|.:.:..|.|.   :.|::.|
Zfish   653 IIQHES-IFPSQNELPGPVYEKCMTLEEDDCEAVAEEGDGESEQVQIKEP---KDELQAL----- 708

  Fly   604 CRALYPFEASSEGSIPMSEGEELQVIEIDQGDGWTRVRRENNSNGWDEGFVPTSYIEI 661
              ||:.:...|...:....|:...|......|.|     :...|| .:|.:|..||.:
Zfish   709 --ALFDYIGRSSTELSFKHGDRFIVYSKASSDWW-----KGEVNG-SKGLIPNKYISV 758

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cip4	NP_001097501.1	F-BAR_CIP4-like	69..319	CDD:153337	52/285 (18%)
		HR1_CIP4-like	412..488	CDD:212009	18/96 (19%)
		SH3_CIP4-like	603..661	CDD:212844	13/57 (23%)
arhgap4a	NP_956738.2	None