DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cip4 and Sh3d19

DIOPT Version :9

Sequence 1:	NP_001097501.1	Gene:	Cip4 / 38534	FlyBaseID:	FBgn0035533	Length:	665	Species:	Drosophila melanogaster
Sequence 2:	XP_006501609.3	Gene:	Sh3d19 / 27059	MGIID:	1350923	Length:	1211	Species:	Mus musculus

Alignment Length:	434	Identity:	76/434 - (17%)
Similarity:	126/434 - (29%)	Gaps:	182/434 - (41%)

- Green bases have known domain annotations that are detailed below.

  Fly   311 MEGIVKAGESINEKEDTFKVIERYQSGFTPPRDIPFEDLSKCDPDSVQDSHYSNSTSNHLTIRGT 375
            :.|:.||...|.:.:|.          ..|||..|...|.:         .|..|..:.:.....
Mouse   802 VSGLSKAKSQIFKNQDP----------VLPPRPKPGHPLYR---------KYMLSVPHGIANEDI 847

  Fly   376 MSANKLK---KRVGIFNIFGSNKNSLTADGQKEDFSDLPPNQRRKKLQAKIAELTQNIAQETKAR 437
            :|.|..:   ||..:..|....:|:.....:.|....:.|:|
Mouse   848 VSRNPTELSCKRGDVLVILKQAENNYLECQRGEGTGRVHPSQ----------------------- 889

  Fly   438 DGLMKMKIVYEANSSLGNPM--TVEGQLNESEHKLEKL--------------------------- 473
                 ||||        .|:  ...|:.|:|.|..:.:
Mouse   890 -----MKIV--------TPLDERPRGRPNDSGHSQKPVDSGAPHAVALHDFPAEQADDLSLTSGE 941

  Fly   474 ------KVDLKKYQGFLEK------ASQVPTATSSPQASRNQLQNGHRTSRHSNGSADDHHDDG- 525
                  |:|.:.|:|....      |:.|......|:.     ::|.|.|..|      |...|
Mouse   942 IVYLLEKIDAEWYRGKCRNQTGVFPANYVKVIVDIPEG-----RSGKRESFSS------HCAKGP 995

  Fly   526 ---------DDQPDDAGSLSRSDSED-------------------------NVAQIQNGHNNNNN 556
                     .||.|:   ||.|:.|.                         |..::...|
Mouse   996 RCVARFEYIGDQKDE---LSFSEGEVIILTEYVNEEWGRGEIRDRSGIFPLNFVELVGDH----- 1052

  Fly   557 GSASPESGLGTSHTSLP----GSGQGSANENAIGEDTYYETEVETLNPVGK-CRALYPFEASSEG 616
                |.||.....|.:|    ....||.::::              :|.|: |:||:.|.|.:..
Mouse  1053 ----PTSGANILSTKVPPKTKNEDPGSNSQDS--------------SPPGEWCKALHSFTAETSE 1099

  Fly   617 SIPMSEGEELQVIEIDQGDGWTRVRRENNSNGWDEGFVPTSYIE 660
            .:|...|:.:.::|....| |.|.|..:.     ||..|..:::
Mouse  1100 DLPFKRGDRILILERLDSD-WYRGRLHDR-----EGIFPAVFVQ 1137

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cip4	NP_001097501.1	F-BAR_CIP4-like	69..319	CDD:153337	3/7 (43%)
		HR1_CIP4-like	412..488	CDD:212009	15/116 (13%)
		SH3_CIP4-like	603..661	CDD:212844	15/59 (25%)
Sh3d19	XP_006501609.3	PHA03247	<50..375	CDD:223021
		PTZ00449	<245..705	CDD:185628
		SH3_Eve1_1	840..889	CDD:212748	8/48 (17%)
		SH3	920..971	CDD:388381	5/50 (10%)
		SH3_Eve1_3	996..1046	CDD:212750	8/52 (15%)
		SH3	1086..1135	CDD:388381	15/54 (28%)
		SH3	1155..1204	CDD:388381
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2056
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.030