DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cip4 and SH3YL1

DIOPT Version :9

Sequence 1:	NP_001097501.1	Gene:	Cip4 / 38534	FlyBaseID:	FBgn0035533	Length:	665	Species:	Drosophila melanogaster
Sequence 2:	NP_056492.2	Gene:	SH3YL1 / 26751	HGNCID:	29546	Length:	342	Species:	Homo sapiens

Alignment Length:	131	Identity:	26/131 - (19%)
Similarity:	42/131 - (32%)	Gaps:	40/131 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   535 LSRSDSEDNVAQIQNGHNNNNNGSASPESGLGTSHTSLPGSGQGSANENAIGEDTYYETEVETLN 599
            |||........|:.:|..:|.|           .:...||...             |...|..||
Human   243 LSRPQQSSAPVQLNSGSQSNRN-----------EYKLYPGLSS-------------YHERVGNLN 283

  Fly   600 PVGKCRALYPFEASSEGSIPMSEGEELQVIEIDQGDGWTRVRRENNSNGWD------EGFVPTSY 658
            ...:..|||.||....|.:....|:.:.||.          :.:::.:.|:      .|..|.:|
Human   284 QPIEVTALYSFEGQQPGDLNFQAGDRITVIS----------KTDSHFDWWEGKLRGQTGIFPANY 338

  Fly   659 I 659
            :
Human   339 V 339

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cip4	NP_001097501.1	F-BAR_CIP4-like	69..319	CDD:153337
		HR1_CIP4-like	412..488	CDD:212009
		SH3_CIP4-like	603..661	CDD:212844	13/63 (21%)
SH3YL1	NP_056492.2	SYLF_SH3YL1_like	11..209	CDD:211401
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	218..266		7/33 (21%)
		SH3_SH3YL1_like	287..340	CDD:212775	13/63 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2056
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.030