Protein Alignment Cip4 and Srgap3

DIOPT Version :9

• Sequence 1: NP_001097501.1
• Gene: Cip4 / 38534
• FlyBaseID: FBgn0035533
• Length: 665
• Species: Drosophila melanogaster
• Sequence 2: XP_006506207.1
• Gene: Srgap3 / 259302
• MGIID: 2152938
• Length: 1104
• Species: Mus musculus
• Alignment Length: 638
• Identity: 113/638 - (17%)
• Similarity: 219/638 - (34%)
• Gaps: 138/638 - (21%)

  Fly    69 TELWDQNENLAIHTNRGIDALDKFANFLRDRVAIETEYAGKLRRLVKNYQPKKKEEEDNEF---- 129
            |:|.:|.:.|...:...:..|.....|.|.:..||.||:..|.:|.:.:..|.:...:::|
Mouse    26 TQLVEQFKCLEQQSESRLQLLQDLQEFFRRKAEIELEYSRSLEKLAERFSSKIRSSREHQFKKDQ 90

  Fly   130 ---TSVQAFRNLLKEVGDLAGQREVVSESLQLQIIAGVTLLSKTLREERKKCLSDGATLQQNLTT 191
               :.|..:..:|.:....:.....:::.....:|..::.:|:.:....||....|..:.:.|..
Mouse    91 YLLSPVNCWYLVLHQTRRESRDHATLNDIFMNNVIVRLSQISEDVIRLFKKSKEIGLQMHEELLK 155

  Fly   192 QLSSLDRAKRNYEKAYRDSEKAVDSYKRA------------DMDLNLSRAE-----------VER 233
            ..:.|....:.|...:.:|..|....|.|            ::.:||.|.|           :|:
Mouse   156 VTNELYTVMKTYHMYHAESISAESKLKEAEKQEEKQFNKSGELSMNLLRHEDRPQRRSSVKKIEK 220

  Fly   234 YKNVMTSKIQQS----DDAKNEYANQLQKTNNLQQQHYSMLLPSVLNRLQELD----EKRTRGFR 290
            .|....:|..::    ..|:|:|...|..||....::|   :..|.:.:...|    ....|.||
Mouse   221 MKEKRQAKYSENKLKCTKARNDYLLNLAATNAAISKYY---IHDVSDLIDCCDLGFHASLARTFR 282

  Fly   291 EFIVGAADVESSVAPIIARCMEG---IVKAGESINEKEDTFKVIERYQSGFTPPRDIPFEDLSKC 352
            .::....::|:|       ..||   |..|.::::.:.|...|::.....|.||....|:
Mouse   283 TYLSAEYNLETS-------RHEGLDVIENAVDNLDSRSDKHTVMDMCSQVFCPPLKFEFQ----- 335

  Fly   353 DPDSVQDSHYSNSTSNHLTIRGTMSANKLKKRVGIFNIFGSNKNSLTADGQKEDFSDLPPNQRRK 417
              ..:.|.....|....:.....|..::|:.|:....|            :.|:.        ||
Mouse   336 --PHMGDEVCQVSAQQPVQTELLMRYHQLQSRLATLKI------------ENEEV--------RK 378

  Fly   418 KLQAKIAELTQNI-AQETKARDGLMKMKIVYEANSSLGNPMTVEGQLNESEHKLEKLKVDLKKYQ 481
            .|.|.:..|...: .::....|.....:......|:...  |...::|.::.:..:.:.::..:.
Mouse   379 TLDATMQTLQDMLTVEDFDVSDAFQHSRSTESIKSAASE--TYMSKINIAKRRANQQETEMFYFT 441

  Fly   482 GFLEKASQVPTATSSPQASRNQLQNGHRTSRHSNGSADDHHDDGDDQPDDAGSLSRSDSEDNVAQ 546
            .|.|..:.....|        :||..|...:.:.         |:.:..:.|:.||.|....:..
Mouse   442 KFKEYVNGSNLIT--------KLQAKHDLLKQTL---------GEGERAECGTTSRRDGRLRLPH 489

  Fly   547 -----------------IQNGHN----NNNNGSASP---ESGL------GTSHTSL---PGSGQG 578
                             .|...|    |.::|.|.|   ||.:      |.....:   ||| |.
Mouse   490 FPWLSCPPAPHFVPHPAFQGRRNARTRNQDSGQAIPLVVESCIRFINLYGLQQQGIFRVPGS-QV 553

  Fly   579 SANE--NAI--GEDTYYETEVE-TLNPVGKCRALYPFEASSEGSIPMSEGEEL 626
            ..|:  |:.  |||...:.:.| .:|.|.....|| |........|....::|
Mouse   554 EVNDIKNSFERGEDPLVDDQNERDINSVAGVLKLY-FRGLENPLFPKERFQDL 605

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cip4	NP_001097501.1	F-BAR_CIP4-like	69..319	CDD:153337	54/290 (19%)
		HR1_CIP4-like	412..488	CDD:212009	11/76 (14%)
		SH3_CIP4-like	603..661	CDD:212844	5/24 (21%)
Srgap3	XP_006506207.1	F-BAR_srGAP3	26..278	CDD:153368	45/254 (18%)
		RhoGAP_srGAP	510..694	CDD:239848	25/98 (26%)
		SH3_srGAP1-3	753..805	CDD:212888

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3565
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810