Protein Alignment Cip4 and SRGAP2

DIOPT Version :10

• Sequence 1: NP_001097501.1
• Gene: Cip4 / 38534
• FlyBaseID: FBgn0035533
• Length: 665
• Species: Drosophila melanogaster
• Sequence 2: XP_011507656.1
• Gene: SRGAP2 / 23380
• HGNCID: 19751
• Length: 1084
• Species: Homo sapiens
• Alignment Length: 795
• Identity: 147/795 - (18%)
• Similarity: 249/795 - (31%)
• Gaps: 240/795 - (30%)

  Fly    70 ELWDQNENLAIHTNRGIDALDKFANFLRDRVAIETEYAGKLRRLVKNYQPKKKEEEDNEF----- 129
            :|.:|.:.|.......:..|....:|.|.:..||.:|:..|.:|.:.:..|.:..:|.:|
Human    27 QLTEQMKCLDQQCELRVQLLQDLQDFFRKKAEIEMDYSRNLEKLAERFLAKTRSTKDQQFKKDQN 91

  Fly   130 --TSVQAFRNLLKEVGDLAGQREVVSESLQLQIIAGVTLLSKTLREERKKCLSDGATLQQNLTTQ 192
              :.|..:..||.:|...:.....:|:.....||.....:|:......||....|..||.:|...
Human    92 VLSPVNCWNLLLNQVKRESRDHTTLSDIYLNNIIPRFVQVSEDSGRLFKKSKEVGQQLQDDLMKV 156

  Fly   193 LSSLDRAKRNYEKAYRDSEKAVDSYKRA-----------------------DMDLNLSRAEVERY 234
            |:.|....:.|.....||..|....|.|                       |...|: |.|.:..
Human   157 LNELYSVMKTYHMYNADSISAQSKLKEAEKQEEKQIGKSVKQEDRQTPRSPDSTANV-RIEEKHV 220

  Fly   235 KNVMTSKIQQSDD---------------AKNEYANQLQKTNNLQQQHYSMLLPSVLNRLQEL--D 282
            :.....||::..:               |:|||...|:.||....::|...|..::::..:|  .
Human   221 RRSSVKKIEKMKEKRQAKYTENKLKAIKARNEYLLALEATNASVFKYYIHDLSDLIDQCCDLGYH 285

  Fly   283 EKRTRGFREFIVGAADVESSVAPIIARCMEGIVKAGESINEKEDTFKVIERYQSGFTPPRDIPFE 347
            ....|..|.|:....::|.|.    ...::.|..|.|:::...|..:::|.|.:.|.||....|:
Human   286 ASLNRALRTFLSAELNLEQSK----HEGLDAIENAVENLDATSDKQRLMEMYNNVFCPPMKFEFQ 346

  Fly   348 ----DLSK--CDPDSVQ----------DSHYSNSTSNHLTIRGTMSA--NKLKKRVGI--FNIFG 392
                |::.  |....||          .|..|.....:..::.||.|  ..::..|.:  |::..
Human   347 PHMGDMASQLCAQQPVQSELVQRCQQLQSRLSTLKIENEEVKKTMEATLQTIQDIVTVEDFDVSD 411

  Fly   393 ----SNKNSLTADGQKEDFSDLPPNQRRK-------------------------KLQAKIAELTQ 428
                ||..........|.|...|...:|:                         ||||| .:|.|
Human   412 CFQYSNSMESVKSTVSETFMSKPSIAKRRANQQETEQFYFTKMKEYLEGRNLITKLQAK-HDLLQ 475

  Fly   429 NIAQETKARDGLM--KMKIVYEANSSLGNPMTVEGQLN-ESEHKLEKLKVDLKKYQGFLEKASQV 490
            ....|::..|..:  :...|.:.:||...|:.||..:. .|.|.|:        ::|...
Human   476 KTLGESQRTDCSLARRSSTVRKQDSSQAIPLVVESCIRFISRHGLQ--------HEGIFR----- 527

  Fly   491 PTATSSPQASRNQLQNG-HRTSRHSNGSADDHHDD-----------GDDQP-------DDAGSLS 536
               .|..|...|.::|. .|......|..:||..|           |.:.|       .|..:..
Human   528 ---VSGSQVEVNDIKNAFERGEDPLAGDQNDHDMDSIAGVLKLYFRGLEHPLFPKDIFHDLMACV 589

  Fly   537 RSD-------------------------------------SEDN--------------VAQIQNG 550
            ..|                                     ||:|              :..:..|
Human   590 TMDNLQERALHIRKVLLVLPKTTLIIMRYLFAFLNHLSQFSEENMMDPYNLAICFGPSLMSVPEG 654

  Fly   551 HN-----------------NNNNGSASP--------------ESGLGTSH---TSLPGSGQGSAN 581
            |:                 .:.|...||              |....:.|   ||:..|.|....
Human   655 HDQVSCQAHVNELIKTIIIQHENIFPSPRELEGPVYSRGGSMEDYCDSPHGETTSVEDSTQDVTA 719

  Fly   582 ENAIGEDTYYETEVETLNPVGKCRALYPFEASSEGSIPMSEGEELQVIEIDQGDGWTRVRRENNS 646
            |:...:|     |.|.:..:.|    :.:...:...:...:|..|.:.:....|.|     |...
Human   720 EHHTSDD-----ECEPIEAIAK----FDYVGRTARELSFKKGASLLLYQRASDDWW-----EGRH 770

  Fly   647 NGWDEGFVPTSYIEI 661
            ||.| |.:|..||.:
Human   771 NGID-GLIPHQYIVV 784

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cip4	NP_001097501.1	F-BAR_CIP4-like	69..319	CDD:153337	59/295 (20%)
		HR1_CIP4-like	412..488	CDD:212009	20/103 (19%)
		SH3_CIP4-like	603..661	CDD:212844	13/57 (23%)
SRGAP2	XP_011507656.1	F-BAR_srGAP2	26..289	CDD:153366	52/262 (20%)
		RhoGAP_srGAP	487..674	CDD:239848	28/202 (14%)
		SH3_srGAP1-3	732..784	CDD:212888	13/61 (21%)
		PHA03269	976..>1078	CDD:165527