DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Cip4 and Itsn2

DIOPT Version :9

Sequence 1:NP_001097501.1 Gene:Cip4 / 38534 FlyBaseID:FBgn0035533 Length:665 Species:Drosophila melanogaster
Sequence 2:NP_001185897.1 Gene:Itsn2 / 20403 MGIID:1338049 Length:1685 Species:Mus musculus


Alignment Length:732 Identity:151/732 - (20%)
Similarity:247/732 - (33%) Gaps:232/732 - (31%)


- Green bases have known domain annotations that are detailed below.


  Fly    32 VRVCAKLLASGSSRSSSNNKLAESENSAQNSNNMSWGTELWDQNENLAIHTNRGIDALDK----F 92
            ::....|:..|||.|:|:       .::.:.|:...||..|...:...:...:..::|||    :
Mouse   206 IQKAQSLIDLGSSSSTSS-------TASLSGNSPKTGTSEWAVPQPSRLKYRQKFNSLDKGMSGY 263

  Fly    93 ANFLRDRVAI------ETEYA-----------GKLRRLVKNYQPKKKEEEDNEFTSVQAFRNLLK 140
            .:..:.|.|:      :|:.|           |:|:.              .||.......::.|
Mouse   264 LSGFQARNALLQSNLSQTQLATIWTLADIDGDGQLKA--------------EEFILAMHLTDMAK 314

  Fly   141 EVGDLAGQ-------REVVSESL----QLQIIAGVTLLS--KTLREERKKCLSDGATLQQNLTTQ 192
                 |||       .|:|..|.    |:..:.| ||.|  ||..||.:|.|.  .|.:      
Mouse   315 -----AGQPLPLTLPPELVPPSFRGGKQVDSVNG-TLPSYQKTQEEEPQKKLP--VTFE------ 365

  Fly   193 LSSLDRAKRNYEKAYRDSEKAVDSYKRADMDLNLSRAEVERYKNVMTSKIQQSDDAKNEYANQLQ 257
                |:.|.|||:...:.|      ||..:.:...:.|.||       |.|:.   |.|:.   :
Mouse   366 ----DKRKANYERGNMELE------KRRQVLMEQQQREAER-------KAQKE---KEEWE---R 407

  Fly   258 KTNNLQQQHY--SMLLPSVLNRLQELDEKRTRGFREFIVGAADVESSVAPIIARCMEGIVKAGES 320
            |...||:|.:  .:.|...|.:.:||:.:|....|                            :.
Mouse   408 KQRELQEQEWKKQLELEKRLEKQRELERQREEERR----------------------------KE 444

  Fly   321 INEKEDTFKVIERYQSGFTPPRDIPFEDLSKCDPDSVQDSHYSNSTSNHLTIRGTMSANKLKKRV 385
            |..:|...:.:||       .|.:.:|.|.                      |..:.:.|.:::.
Mouse   445 IERREAAKQELER-------QRRLEWERLR----------------------RQELLSQKTREQE 480

  Fly   386 GIFNIFGSNKNSL-----TADGQKEDFSD-LPPNQRRKKLQ------------AKIAELTQNIAQ 432
            .|..: .|.|.||     ..:|:.:..|. |...|.||:.|            .:|.|:.| :.|
Mouse   481 DIVRL-SSRKKSLHLELEAVNGKHQQISGRLQDVQIRKQTQKTELEVLDKQCDLEIMEIKQ-LQQ 543

  Fly   433 ETKARDGLMKMKIVYEA-----------NSSLGN-PMTVEGQLNESEHKLEKLKVDLKKYQGFLE 485
            |.|.    .:.|::|..           |..|.| |.:....|::...:.|:|...||:....||
Mouse   544 ELKE----YQNKLIYLVPEKQLLNERIKNMQLSNTPDSGISLLHKKSSEKEELCQRLKEQLDALE 604

  Fly   486 KASQVPTATSSPQASRNQLQNGH--------------------------RTSRHSNGSA-DDHHD 523
            |  :..:..|...:..|||:.|.                          |.|.::...| :..|.
Mouse   605 K--ETASKLSEMDSFNNQLKCGSMDDCVLQCLLSLLSCLNNLFLLLKELRESYNTQQLALEQLHK 667

  Fly   524 DGDDQPDD-----AGSLSRSDSEDNVA-QIQNGHNNNNNGSASPESGLGTSHTSLPGSGQGSANE 582
            ...|:..:     ...:.:...||..| :.:.|..|....|...|............|...:..|
Mouse   668 IKRDKLKEIERKRLEQIQKKKLEDEAARKAKQGKENLWRESIRKEEEEKQKRLQEEKSQDKTQEE 732

  Fly   583 NAIGEDTYYETEVETLNPVGKCRALYPFEASSEGSIPMSEGEELQVIEIDQGD-GWTRVRRENNS 646
            ....|....||....:|    .||||||||.:...:..|.|:.:||.|...|: ||.....:...
Mouse   733 ERKAEAKQSETASALVN----YRALYPFEARNHDEMSFSSGDIIQVDEKTVGEPGWLYGSFQGKF 793

  Fly   647 NGWDEGFVPTSYIEITL 663
             ||    .|.:|:|..|
Mouse   794 -GW----FPCNYVEKVL 805

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Cip4NP_001097501.1 F-BAR_CIP4-like 69..319 CDD:153337 57/285 (20%)
HR1_CIP4-like 412..488 CDD:212009 24/99 (24%)
SH3_CIP4-like 603..661 CDD:212844 20/58 (34%)
Itsn2NP_001185897.1 EH 15..107 CDD:197477
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 220..242 6/28 (21%)
EH 238..317 CDD:197477 14/97 (14%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 335..382 18/65 (28%)
Smc 350..>747 CDD:224117 95/492 (19%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 716..742 3/25 (12%)
SH3_Intersectin2_1 747..803 CDD:212921 21/64 (33%)
INTAP 806..883 CDD:374674 151/732 (21%)
SH3_Intersectin2_2 883..934 CDD:212923
SH3_Intersectin2_3 973..1024 CDD:212925
SH3_Intersectin2_4 1045..1103 CDD:212927
SH3_Intersectin2_5 1118..1171 CDD:212929
RhoGEF 1202..1381 CDD:366202
PH_13 1400..1554 CDD:374702
C2_Intersectin 1543..1677 CDD:176021
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R2056
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
21.940

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