DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cip4 and Fnbp1

DIOPT Version :9

Sequence 1:	NP_001097501.1	Gene:	Cip4 / 38534	FlyBaseID:	FBgn0035533	Length:	665	Species:	Drosophila melanogaster
Sequence 2:	NP_620269.1	Gene:	Fnbp1 / 192348	RGDID:	621350	Length:	620	Species:	Rattus norvegicus

Alignment Length:	659	Identity:	227/659 - (34%)
Similarity:	348/659 - (52%)	Gaps:	110/659 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    65 MSWGTELWDQNENLAIHTNRGIDALDKFANFLRDRVAIETEYAGKLRRLVKNYQPKK--KEEEDN 127
            ||||||||||.:||..||..|||.|:|:..|:::|..||..||.:||.|.|.|||||  ||||:.
  Rat     1 MSWGTELWDQFDNLEKHTQWGIDILEKYIKFVKERTEIELSYAKQLRNLSKKYQPKKNSKEEEEY 65

  Fly   128 EFTSVQAFRNLLKEVGDLAGQREVVSESLQLQIIAGVTLLSKTLREERKKCLSDGATLQQNLTTQ 192
            ::|:.:||.:.|.|:.|.|||.||:||::..||...:....:.|::|||....||...||::.|.
  Rat    66 KYTACKAFLSTLNELNDYAGQHEVISENMTSQITVDLVRYVQELKQERKSNFHDGRKAQQHIETC 130

  Fly   193 LSSLDRAKRNYEKAYRDSEKAVDSYKRADMDLNLSRAEVERYKNVMTSKIQQSDDAKNEYANQLQ 257
            ...|:.:||.:|:..:::::|...:::.|.|:|:::|:||:.:.....:.|.::|:|.:|:..||
  Rat   131 WKQLESSKRRFERDCKEADRAQQYFEKMDADINVTKADVEKARQQAQMRQQMAEDSKADYSLILQ 195

  Fly   258 KTNNLQQQHYSMLLPSVLNRLQELDEKRTRGFREFIVGAADVESSVAPIIARCMEGIVKAGESIN 322
            :.|..|.::|...:|::..::||::|:|.....|.:...|:|:..|.|||.:|::|||||.|||:
  Rat   196 RFNQEQWEYYHTHIPNIFQKIQEMEERRIVRIGESMKTYAEVDRQVIPIIGKCLDGIVKAAESID 260

  Fly   323 EKEDTFKVIERYQSGFTPPRDIPFEDLSKCDPDSVQDSHYSNS---------------------- 365
            :|.|:..|:|.|:|||.||.||.|||.::....:|.|:..|:|
  Rat   261 QKNDSQLVVEAYKSGFEPPGDIEFEDYTQPMKRTVSDNSLSSSKEGKPELKFGGKSRGKLWPFIK 325

  Fly   366 --------TSNH-------------LTIRGTMSANKLKKRVG-IFNIFGSNKN------------ 396
                    ||.|             ....|..|..:.|:.:. .||.|.::|.
  Rat   326 KNKLMTLLTSPHQPPPPPPASASPSAVPNGPQSPKQQKEPLSHRFNEFMTSKPKIHCFRSLKRGL 390

  Fly   397 SLTADGQKEDFSDLPPNQRRKKLQAKIAELTQNIAQETKARDGLMKMKIVYEANSSLGNPMTVEG 461
            ||......||||:.||.|||||||.|:.:|.:.|.:||..||.:.|||.||..|..:|:|.:::.
  Rat   391 SLKLGVTPEDFSNFPPEQRRKKLQQKVDDLNKEIQKETDQRDAITKMKDVYLKNPQMGDPASLDH 455

  Fly   462 QLNESEHKLEKLKVDLKKYQGFL-EKASQVPTATSSPQASRNQ-LQNGHRTSRHSNGSADDHHDD 524
            :|.|....:|||:::..|::.:| |...::|  ..|.||.|.. |.:| :|.:.....|.|.
  Rat   456 KLAEVTQNIEKLRLEAHKFEAWLAEVEGRLP--ARSEQARRQSGLYDG-QTHQTVTNCAQDR--- 514

  Fly   525 GDDQPDDAGSLSRSDSEDNVAQIQNGHNNNNNGSASPESGLGTSHTSLPGSGQGSANENAIGEDT 589
              :.||                          ||.:.|....:.|..|           |...|.
  Rat   515 --ESPD--------------------------GSYTEEQSQESEHKVL-----------ATDFDD 540

  Fly   590 YYETEVETLNPVGKCRALYPFEASSEGSIPMSEGEELQVIEIDQGDGWTRVRRENNSNGWDEGFV 654
            .::.| |.|..:|.|:|||.||..:||:|.:.|||.|.|||.|:||||||:||..:    :||:|
  Rat   541 EFDDE-EPLPAIGTCKALYTFEGQNEGTISVVEGETLSVIEEDKGDGWTRIRRNED----EEGYV 600

  Fly   655 PTSYIEITL 663
            ||||:|:.|
  Rat   601 PTSYVEVYL 609

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cip4	NP_001097501.1	F-BAR_CIP4-like	69..319	CDD:153337	96/251 (38%)
		HR1_CIP4-like	412..488	CDD:212009	31/76 (41%)
		SH3_CIP4-like	603..661	CDD:212844	32/57 (56%)
Fnbp1	NP_620269.1	Interaction with microtubules	1..334		122/332 (37%)
		Required for self-association and induction of membrane tubulation. /evidence=ECO:0000250	1..79		42/77 (55%)
		F-BAR_FBP17	5..257	CDD:153360	96/251 (38%)
		Required for self-association and induction of membrane tubulation. /evidence=ECO:0000250	251..616		132/409 (32%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	280..314		9/33 (27%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	332..365		6/32 (19%)
		Interaction with RND2	399..551		58/197 (29%)
		HR1_FBP17	406..482	CDD:212019	31/75 (41%)
		Interaction with PDE6G	494..616		53/164 (32%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	494..531		11/68 (16%)
		Required for interaction with TNKS. /evidence=ECO:0000250	513..616		48/144 (33%)
		Interaction with DNM1 and DNM3. /evidence=ECO:0000250	534..616		41/92 (45%)
		Interaction with ARHGAP17, DAAM1, DIAPH1 and DIAPH2. /evidence=ECO:0000250	549..616		35/65 (54%)
		Interaction with FASLG. /evidence=ECO:0000250	552..609		34/60 (57%)
		Interaction with DNM2 and WASL. /evidence=ECO:0000250	552..608		34/59 (58%)
		SH3_FBP17	552..608	CDD:213004	34/59 (58%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166351728
Domainoid	1	1.000	203	1.000	Domainoid score	I2861
eggNOG	1	0.900	-	-		E1_KOG3565
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	359	1.000	Inparanoid score	I2141
OMA	1	1.010	-	-		QHG51860
OrthoDB	1	1.010	-	-		D348563at2759
OrthoFinder	1	1.000	-	-		FOG0001169
OrthoInspector	1	1.000	-	-		otm44676
orthoMCL	1	0.900	-	-		OOG6_103782
Panther	1	1.100	-	-	O	PTHR15735
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X890
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	14	13.810