DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cip4 and srgp-1

DIOPT Version :9

Sequence 1:	NP_001097501.1	Gene:	Cip4 / 38534	FlyBaseID:	FBgn0035533	Length:	665	Species:	Drosophila melanogaster
Sequence 2:	NP_001255566.1	Gene:	srgp-1 / 178079	WormBaseID:	WBGene00006406	Length:	1059	Species:	Caenorhabditis elegans

Alignment Length:	560	Identity:	111/560 - (19%)
Similarity:	204/560 - (36%)	Gaps:	111/560 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    69 TELWDQNENLAIHTNRGIDALDKFANFLRDRVAIETEYAGKLRRLVKNYQPKKKEEEDN-----E 128
            |::.||.:.|...|:..:.:|.:..::.|.|..||:|||.||.:|.|:...|.|.|...     :
Worm    60 TKMSDQLKCLGDRTDVQMSSLSELQDYFRKRGEIESEYACKLEKLSKSIAQKHKSERSRREGWPQ 124

  Fly   129 FTSVQAFRNLLKEVGDLAGQREVVSESLQLQIIAGVTLLSKTLREERKKCLSDGATLQQNLTTQL 193
            .||...:..|:::..:...:|:.:.|....|:.|.:....:.|.:..|:|...|:.....|...|
Worm   125 HTSSTVWHTLVEQTKEEYKKRQSLGELYGKQMTASIETRCEDLAKISKRCREIGSYSHNELNRVL 189

  Fly   194 SSLDRAKRNYEKAY-------RDSEKAVDSYKRADMDLNLSRAEVERYKNVMTSKIQQSDD---- 247
            :.|..|.:.|:..|       |....|.:..||.: |.|..:.|..|....:....::.::
Worm   190 TELQTAMKTYQLCYAEMCGIERKKRSAEEDVKRYE-DSNPGKYEGSRRHRSLVKYFKRREEKFEV 253

  Fly   248 -------AKNEYANQLQKTNNLQQQHYSMLLPSVLNRLQELDEKRTRGFREFIVGAADVESSVAP 305
                   |:|||...::..|....:.::..|..:::.:....:...|...|.::   |....:..
Worm   254 VRLKCTKARNEYLLCVKAANAALHRFFAQDLSYLIDCMDLGMDFWLRALLEKVI---DERKKITQ 315

  Fly   306 IIARCMEGIVKAGESINEKEDTFKVIERYQSGFTPPRDIPFEDLSKCDP---DSVQDSHYSNSTS 367
            .....:..:.....|::.|.|..|..|.....|..|:...|.      |   |.:.:.....|.|
Worm   316 HEMDSLASLSTLRSSVDVKADKQKFFEANHQLFMLPKQFEFR------PQLGDDIMEVSAEQSLS 374

  Fly   368 NHLTIRGTMSANKL------------------KKRVGIFNI-----FGSNKNSLTADGQK----- 404
            :.|..|......:|                  |:.:.::|.     .|..:|.|....|.
Worm   375 SDLLQRQLQIEKRLEGLQFEVDEVWKSLEASEKQLLQLYNTQFDGEAGKWRNDLHVTYQYYLKKF 439

  Fly   405 EDFSDLPPNQRRKKLQAKIAELTQNIAQETKARDGL-MKMKIVYEANSSLGNPMTVEGQLNESEH 468
            |.|  |......::|:|:.|.:     .|...:.|: :|...|..|:...|: .|.|...:::.|
Worm   440 EHF--LLNGNLMERLEARSASI-----GEALGKHGISLKSASVGSASERNGS-FTTENGGSQNHH 496

  Fly   469 KLEKLKVDLKKYQGFLEKA----------------------SQVPTATSSPQA--SRNQLQN--- 506
            .||:.:...::..|.:.|:                      .::|....|..|  ||..|:|
Worm   497 LLEERRSKARRIGGIVTKSPDDRPRPKLFGGSLDEYVEATGEEIPLLVQSAIAYLSRYSLRNQGL 561

  Fly   507 ----GHRTS----RHSNGSADD---HHDDGDDQPDDAGSL 535
                |.::.    |.:....:|   :.|||.|....||.|
Worm   562 FRVSGSQSEINRFREAYERGEDLFQYLDDGSDANSAAGVL 601

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cip4	NP_001097501.1	F-BAR_CIP4-like	69..319	CDD:153337	54/272 (20%)
		HR1_CIP4-like	412..488	CDD:212009	16/98 (16%)
		SH3_CIP4-like	603..661	CDD:212844
srgp-1	NP_001255566.1	F-BAR_srGAP	60..300	CDD:153340	51/240 (21%)
srgp-1	NP_001255566.1	RhoGAP	523..710	CDD:383032	17/79 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910