Protein Alignment Cip4 and toca-2

DIOPT Version :9

• Sequence 1: NP_001097501.1
• Gene: Cip4 / 38534
• FlyBaseID: FBgn0035533
• Length: 665
• Species: Drosophila melanogaster
• Sequence 2: NP_499838.2
• Gene: toca-2 / 176812
• WormBaseID: WBGene00010663
• Length: 610
• Species: Caenorhabditis elegans
• Alignment Length: 623
• Identity: 161/623 - (25%)
• Similarity: 308/623 - (49%)
• Gaps: 62/623 - (9%)

  Fly    73 DQNENLAIHTNRGIDALDKFANFLRDRVAIETEYAGKLRRLVKNYQPKKKEEEDNEFTSV---QA 134
            |.:..|..:|.:|||..:|...|.:::.|||.||:.|||.|.|.| .||.||:|....||   .:
 Worm    12 DPSNALLSYTQKGIDFFEKLGQFSKEKAAIEEEYSTKLRSLAKKY-AKKSEEDDEILKSVSYTSS 75

  Fly   135 FRNLLKEVGDLAGQREVVSESLQLQIIAGVTLLSKTLREERKKCLSDGATLQQNLTTQLSSLDRA 199
            |.:.|:::..:|.:.:..:|.::..:::.|...:..:|..||..::|..|:...|..|::.:.::
 Worm    76 FNSFLQQLDQIATRHQTSAEHIRGGVVSYVASKTCQMRSSRKNAINDLKTINDKLEDQINEMCKS 140

  Fly   200 KRNYEKAYRDSEKAVDSYKRADMDLNLSRAEVERYKNVMTSKIQQSDDAKNEYANQLQKTNNLQQ 264
            .:.|.|:::|:|.:...:.:||.:|.:||.|:|:.:.:..::.:..:.||.:|:..::|||..|:
 Worm   141 GKCYLKSFKDAENSYQKFYKADKNLEISRLELEKARALANARNEACELAKQDYSALVRKTNAEQK 205

  Fly   265 QHYSMLLPSVLNRLQELDEKRTRGFREFIVGAADVESSVAPIIARCMEGIVKAGESINEKEDTFK 329
            :::..|||.:..||:.:|::.....|:.:......:.|:|.....|.:.:.:....|:.:.|...
 Worm   206 RYHVELLPVIFARLKAVDKECIADMRQVLQKIVSFDDSLADSTEECRKIMQREVGKIDAEGDAQL 270

  Fly   330 VIERYQSGFTPPRDIPFEDLSKCDPDSVQDSHYSNST--SNHLTIRGTMSANK-LKKRVGIFNIF 391
            |::..::....|.....|||.  ||.:. ||..::|.  |....::.:.|.|: ::..:||....
 Worm   271 VLKSVEATIEQPAPFEIEDLG--DPKNC-DSRTNDSADGSGGKLLKSSPSKNRIIRNFLGILKEK 332

  Fly   392 GSNKNSLTADGQKEDFSD--LPPNQRRKKLQAKIAELTQNIAQETKARDGLMKMKIVYEANSSLG 454
            .:::....::..:..::|  .|.:.|...|::||.::.:.:.|..:.|:|:.:::..|..|...|
 Worm   333 EADEKPEASNNDQLMYTDKSKPAHVRLSCLRSKIRDMEKQLEQAIQGREGITRLQQAYYTNPQHG 397

  Fly   455 NPMTVEGQLNESEHKLEKLKVD---LKKYQGFLEKASQVPTATS-----SPQASRNQLQNGHRTS 511
            ||......|.....|:||||:|   ||::...||.:.:.....|     :|..:|:  .:|..|:
 Worm   398 NPSACTEPLISYAKKIEKLKMDIHNLKEFYAMLEMSVEEGQERSFGGRDTPDTTRS--MSGSSTN 460

  Fly   512 RHSNGSADDHHDDGDDQPDDAG-SLSRSDSEDNVAQIQNGHNNNNNGSASPESGLGTSHTSLP-- 573
            :.|:.:.:      |....:|| |.|..||..|:  ::..........:||:    ||.:|.|
 Worm   461 QSSSKTIE------DVLSGEAGNSSSADDSSKNI--LRQLFTTPKRLISSPK----TSKSSTPTP 513

  Fly   574 --------------GSGQGSANENAIGEDTYYETEVETLNPVGKCRALYPFEASSEGSIPMSEGE 624
                          .|..|:..::....|:   .:|||...|   .||:.|..||..::.:.:||
 Worm   514 LRRRAEISSPKILRSSFSGAIRKSLSTPDS---VKVETAVTV---TALFEFAKSSAETMSIEQGE 572

  Fly   625 ELQVIEIDQGDGWTRVR--RENNSNGWDEGFVPTSYIE 660
            .|.|:|.|.||||||.:  |::|.   :.|||||||::
 Worm   573 ILLVLEHDHGDGWTRTKNCRKHNE---ESGFVPTSYLQ 607

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cip4	NP_001097501.1	F-BAR_CIP4-like	69..319	CDD:153337	66/248 (27%)
		HR1_CIP4-like	412..488	CDD:212009	23/78 (29%)
		SH3_CIP4-like	603..661	CDD:212844	26/60 (43%)
toca-2	NP_499838.2	F-BAR_CIP4-like	8..267	CDD:153337	67/255 (26%)
		HR1_CIP4-like	356..431	CDD:212009	21/74 (28%)
		SH3_CIP4-like	551..608	CDD:212844	27/63 (43%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160165718
Domainoid	1	1.000	145	1.000	Domainoid score	I2828
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG51860
OrthoDB	1	1.010	-	-		D348563at2759
OrthoFinder	1	1.000	-	-		FOG0001169
OrthoInspector	1	1.000	-	-		otm14310
orthoMCL	1	0.900	-	-		OOG6_103782
Panther	1	1.100	-	-	O	PTHR15735
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X890
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	10	9.860