DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cip4 and Arhgap4

DIOPT Version :9

Sequence 1:	NP_001097501.1	Gene:	Cip4 / 38534	FlyBaseID:	FBgn0035533	Length:	665	Species:	Drosophila melanogaster
Sequence 2:	XP_011245832.1	Gene:	Arhgap4 / 171207	MGIID:	2159577	Length:	965	Species:	Mus musculus

Alignment Length:	530	Identity:	95/530 - (17%)
Similarity:	178/530 - (33%)	Gaps:	136/530 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    65 MSWGTELWDQNENLAIHTNRGIDALDKFANFLRDRVAIETEYAGKLRRLVKNYQPKK-----KEE 124
            |.|  :|.:|...|.:......|.|.:.|.|:|.|..:|.||:..|.:|.:.:..:.     ..:
Mouse    28 MRW--QLSEQLHCLELQGELRRDLLQELAEFMRRRAEVELEYSRGLDKLAERFTSRSGRLGGSSQ 90

  Fly   125 EDNEF-------TSVQAFRNLLKEVGDLAGQREVVSESLQLQIIAGVTLLSKTLREERKKCLSDG 182
            |...|       :.:..:..||:.....:.:...:||.|...:...::.:|:.:....||.....
Mouse    91 EQQSFRKEPTLLSPLHCWAVLLEHTRQQSRESAALSEVLAGPLAQRLSHISEDVGRIVKKSKDLV 155

  Fly   183 ATLQQNLTTQLSSLDRAKRNYEKAYRDSEKAVDSYKRADMDLNLSRAEVER-------------- 233
            ..||..|...:|.|...|:.|...:.:|..|....:.|:      |.|.:|
Mouse   156 QQLQAELLEVVSELQTTKKMYHVYHSESMNAETKLREAE------RQEEKRSGRSALSTTTTTSA 214

  Fly   234 YKNVMTSKIQQSDDAKNEYANQLQKTNNLQQQHYSMLLPSVLNRLQELDEKRTRGFREFIVGAAD 298
            .....|:.::.....|    :.|:|...|.::..:..|...|        |.|:...|:::..|.
Mouse   215 TTTTTTTTVETGPHRK----SSLKKGGRLVEKRQAKYLEHKL--------KCTKARNEYLLSLAS 267

  Fly   299 VESSVA--------PIIARC--------------------------MEG---IVKAGESINEKED 326
            |.::::        .::..|                          |:|   :.:|.|:::...|
Mouse   268 VNAAISNYYLHDILDLMDCCDTGFHLALEQALRSYTAAESRTQTSQMQGLGSLEEALEALDPPGD 332

  Fly   327 TFKVIERYQSGFTPPRDI---PFEDLSKCDPDSVQDSHYSNSTSNHLTIRGTMSANKLKKRVGIF 388
            ..||:|.:...|.||...   |.||      |.|.:........:.:..|    |..::.|:
Mouse   333 KAKVLEVHAMAFCPPLRFEYQPHED------DEVAEVLIEMELWDEILPR----AQNIQSRL--- 384

  Fly   389 NIFGSNKNSLTADGQKEDFSDLPPNQRRKKLQAKIAELTQNIAQET-KARDGLMKMKIVYEANSS 452
                             |...:...:..|.|:|.:..|.:.:|.|. ...|.|..........|:
Mouse   385 -----------------DQKTIETEEVNKTLKATLKALLEAVASEDGDILDSLQASPSTESLKST 432

  Fly   453 LGNPMTVE-----GQLNESE--------------HKLEKLKVDLKKYQGFLEKASQVPTATSSPQ 498
            ..:|.|.:     .|..|:|              ..|.||:...:|.|..:::.::....||..|
Mouse   433 SSDPGTRQTGRRRNQQQETETFYITKLQEYLSGRSILSKLQAKHEKLQEAIQQGNKEKQETSRTQ 497

  Fly   499 ASRNQLQNGH 508
            .:..:....|
Mouse   498 CTERKFHKSH 507

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cip4	NP_001097501.1	F-BAR_CIP4-like	69..319	CDD:153337	53/312 (17%)
		HR1_CIP4-like	412..488	CDD:212009	19/95 (20%)
		SH3_CIP4-like	603..661	CDD:212844
Arhgap4	XP_011245832.1	F-BAR_srGAP	30..296	CDD:153340	51/285 (18%)
		RhoGAP	518..705	CDD:383032
		SH3	769..823	CDD:388381
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3565
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810