DRSC/TRiP Functional Genomics Resources

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Protein Alignment Cip4 and Srgap2

DIOPT Version :10

Sequence 1:NP_001097501.1 Gene:Cip4 / 38534 FlyBaseID:FBgn0035533 Length:665 Species:Drosophila melanogaster
Sequence 2:NP_001074480.2 Gene:Srgap2 / 14270 MGIID:109605 Length:1071 Species:Mus musculus


Alignment Length:797 Identity:145/797 - (18%)
Similarity:248/797 - (31%) Gaps:244/797 - (30%)


- Green bases have known domain annotations that are detailed below.


  Fly    70 ELWDQNENLAIHTNRGIDALDKFANFLRDRVAIETEYAGKLRRLVKNYQPKKKEEEDNEF----- 129
            :|.:|.:.|.......:..|....:|.|.:..||.:|:..|.:|.:.:..|.:..:|.:|     
Mouse    27 QLTEQMKCLDQQCELRVQLLQDLQDFFRKKAEIEMDYSRNLEKLAERFLAKTRSTKDQQFKKDQN 91

  Fly   130 --TSVQAFRNLLKEVGDLAGQREVVSESLQLQIIAGVTLLSKTLREERKKCLSDGATLQQNLTTQ 192
              :.|..:..||.:|...:.....:|:.....||.....:|:......||....|..||.:|...
Mouse    92 VLSPVNCWNLLLNQVKRESRDHTTLSDIYLNNIIPRFVQVSEDSGRLFKKSKEVGQQLQDDLMKV 156

  Fly   193 LSSLDRAKRNYEKAYRDSEKAVDSYKRA-----------------------DMDLNLSRAEVERY 234
            |:.|....:.|.....||..|....|.|                       |...|: |.|.:..
Mouse   157 LNELYSVMKTYHMYNADSISAQSKLKEAEKQEEKQIGKSVKQEDRQTPRSPDSTANV-RIEEKHV 220

  Fly   235 KNVMTSKIQQSDD---------------AKNEYANQLQKTNNLQQQHYSMLLPSVLNRLQEL--D 282
            :.....||::..:               |:|||...|:.||....::|...|..::::..:|  .
Mouse   221 RRSSVKKIEKMKEKRQAKYTENKLKAIKARNEYLLALEATNASVFKYYIHDLSDIIDQCCDLGYH 285

  Fly   283 EKRTRGFREFIVGAADVESSVAPIIARCMEGIVKAGESINEKEDTFKVIERYQSGFTPPRDIPFE 347
            ....|..|.|:....::|.|.    ...::.|..|.|:::...|..:::|.|.:.|.||....|:
Mouse   286 ASLNRALRTFLSAELNLEQSK----HEGLDAIENAVENLDATSDKQRLMEMYNNVFCPPMKFEFQ 346

  Fly   348 ----DLSK--CDPDSVQ----------DSHYSNSTSNHLTIRGTMSA--NKLKKRVGI--FNIFG 392
                |::.  |....||          .|..|.....:..::.||.|  ..::..|.:  |::..
Mouse   347 PHMGDMASQLCAQQPVQSELVQRCQQLQSRLSTLKIENEEVKKTMEATLQTIQDIVTVEDFDVSD 411

  Fly   393 ----SNKNSLTADGQKEDFSDLPPNQRRK-------------------------KLQAKIAELTQ 428
                ||..........|.|...|...:|:                         ||||| .:|.|
Mouse   412 CFQYSNSMESVKSTVSETFMSKPSIAKRRANQQETEQFYFTKMKEYLEGRNLITKLQAK-HDLLQ 475

  Fly   429 NIAQETKARDGLM--KMKIVYEANSSLGNPMTVEGQLN-ESEHKLEKLKVDLKKYQGFLEKASQV 490
            ....|::..|..:  :...|.:.:||...|:.||..:. .|.|.|:        ::|...     
Mouse   476 KTLGESQRTDCSLARRSSTVRKQDSSQAIPLVVESCIRFISRHGLQ--------HEGIFR----- 527

  Fly   491 PTATSSPQASRNQLQNGHRTSRHSNGSADDHHDDGDDQ-----------------PDD------- 531
               .|..|...|.::|..  .|..:..|.|.:|...|.                 |.|       
Mouse   528 ---VSGSQVEVNDIKNAF--ERGEDPLAGDQNDHDMDSIAGVLKLYFRGLEHPLFPKDIFHDLIA 587

  Fly   532 -----------------------------------AGSLSRSDSED-----NVA--------QIQ 548
                                               ...||:...|:     |:|        .:.
Mouse   588 CVTMDNLQERAVHIRKVLLVLPKPTLIIMRYLFAFLNHLSQFSEENMMDPYNLAICFGPSLMSVP 652

  Fly   549 NGHNNNN-------------------------------NGSASPESGLGTSH---TSLPGSGQGS 579
            .||:..:                               :...|.|....::|   ||...|.|..
Mouse   653 EGHDQVSCQAHVNELIKTIIIQHENIFPNPRELEGPIYSRGGSMEDYCDSTHGETTSAEDSTQDV 717

  Fly   580 ANENAIGEDTYYETEVETLNPVGKCRALYPFEASSEGSIPMSEGEELQVIEIDQGDGWTRVRREN 644
            ..|:...:|     |.|.:..:.|    :.:...:...:...:|..|.:.:....|.|     |.
Mouse   718 TAEHHTSDD-----ECEPIEAIAK----FDYVGRTARELSFKKGASLLLYQRASDDWW-----EG 768

  Fly   645 NSNGWDEGFVPTSYIEI 661
            ..||.| |.:|..||.:
Mouse   769 RHNGID-GLIPHQYIVV 784

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Cip4NP_001097501.1 F-BAR_CIP4-like 69..319 CDD:153337 59/295 (20%)
HR1_CIP4-like 412..488 CDD:212009 20/103 (19%)
SH3_CIP4-like 603..661 CDD:212844 13/57 (23%)
Srgap2NP_001074480.2 F-BAR_srGAP2 26..289 CDD:153366 52/262 (20%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 181..211 3/29 (10%)
RhoGAP_srGAP 487..674 CDD:239848 28/204 (14%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 700..726 6/25 (24%)
SH3_srGAP1-3 732..784 CDD:212888 13/61 (21%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 795..819
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 838..918
PHA03269 963..>1065 CDD:165527
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 984..1012
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1029..1071
Blue background indicates that the domain is not in the aligned region.

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