DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cip4 and Srgap2

DIOPT Version :9

Sequence 1:	NP_001097501.1	Gene:	Cip4 / 38534	FlyBaseID:	FBgn0035533	Length:	665	Species:	Drosophila melanogaster
Sequence 2:	NP_001074480.2	Gene:	Srgap2 / 14270	MGIID:	109605	Length:	1071	Species:	Mus musculus

Alignment Length:	797	Identity:	145/797 - (18%)
Similarity:	248/797 - (31%)	Gaps:	244/797 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    70 ELWDQNENLAIHTNRGIDALDKFANFLRDRVAIETEYAGKLRRLVKNYQPKKKEEEDNEF----- 129
            :|.:|.:.|.......:..|....:|.|.:..||.:|:..|.:|.:.:..|.:..:|.:|
Mouse    27 QLTEQMKCLDQQCELRVQLLQDLQDFFRKKAEIEMDYSRNLEKLAERFLAKTRSTKDQQFKKDQN 91

  Fly   130 --TSVQAFRNLLKEVGDLAGQREVVSESLQLQIIAGVTLLSKTLREERKKCLSDGATLQQNLTTQ 192
              :.|..:..||.:|...:.....:|:.....||.....:|:......||....|..||.:|...
Mouse    92 VLSPVNCWNLLLNQVKRESRDHTTLSDIYLNNIIPRFVQVSEDSGRLFKKSKEVGQQLQDDLMKV 156

  Fly   193 LSSLDRAKRNYEKAYRDSEKAVDSYKRA-----------------------DMDLNLSRAEVERY 234
            |:.|....:.|.....||..|....|.|                       |...|: |.|.:..
Mouse   157 LNELYSVMKTYHMYNADSISAQSKLKEAEKQEEKQIGKSVKQEDRQTPRSPDSTANV-RIEEKHV 220

  Fly   235 KNVMTSKIQQSDD---------------AKNEYANQLQKTNNLQQQHYSMLLPSVLNRLQEL--D 282
            :.....||::..:               |:|||...|:.||....::|...|..::::..:|  .
Mouse   221 RRSSVKKIEKMKEKRQAKYTENKLKAIKARNEYLLALEATNASVFKYYIHDLSDIIDQCCDLGYH 285

  Fly   283 EKRTRGFREFIVGAADVESSVAPIIARCMEGIVKAGESINEKEDTFKVIERYQSGFTPPRDIPFE 347
            ....|..|.|:....::|.|.    ...::.|..|.|:::...|..:::|.|.:.|.||....|:
Mouse   286 ASLNRALRTFLSAELNLEQSK----HEGLDAIENAVENLDATSDKQRLMEMYNNVFCPPMKFEFQ 346

  Fly   348 ----DLSK--CDPDSVQ----------DSHYSNSTSNHLTIRGTMSA--NKLKKRVGI--FNIFG 392
                |::.  |....||          .|..|.....:..::.||.|  ..::..|.:  |::..
Mouse   347 PHMGDMASQLCAQQPVQSELVQRCQQLQSRLSTLKIENEEVKKTMEATLQTIQDIVTVEDFDVSD 411

  Fly   393 ----SNKNSLTADGQKEDFSDLPPNQRRK-------------------------KLQAKIAELTQ 428
                ||..........|.|...|...:|:                         ||||| .:|.|
Mouse   412 CFQYSNSMESVKSTVSETFMSKPSIAKRRANQQETEQFYFTKMKEYLEGRNLITKLQAK-HDLLQ 475

  Fly   429 NIAQETKARDGLM--KMKIVYEANSSLGNPMTVEGQLN-ESEHKLEKLKVDLKKYQGFLEKASQV 490
            ....|::..|..:  :...|.:.:||...|:.||..:. .|.|.|:        ::|...
Mouse   476 KTLGESQRTDCSLARRSSTVRKQDSSQAIPLVVESCIRFISRHGLQ--------HEGIFR----- 527

  Fly   491 PTATSSPQASRNQLQNGHRTSRHSNGSADDHHDDGDDQ-----------------PDD------- 531
               .|..|...|.::|..  .|..:..|.|.:|...|.                 |.|
Mouse   528 ---VSGSQVEVNDIKNAF--ERGEDPLAGDQNDHDMDSIAGVLKLYFRGLEHPLFPKDIFHDLIA 587

  Fly   532 -----------------------------------AGSLSRSDSED-----NVA--------QIQ 548
                                               ...||:...|:     |:|        .:.
Mouse   588 CVTMDNLQERAVHIRKVLLVLPKPTLIIMRYLFAFLNHLSQFSEENMMDPYNLAICFGPSLMSVP 652

  Fly   549 NGHNNNN-------------------------------NGSASPESGLGTSH---TSLPGSGQGS 579
            .||:..:                               :...|.|....::|   ||...|.|..
Mouse   653 EGHDQVSCQAHVNELIKTIIIQHENIFPNPRELEGPIYSRGGSMEDYCDSTHGETTSAEDSTQDV 717

  Fly   580 ANENAIGEDTYYETEVETLNPVGKCRALYPFEASSEGSIPMSEGEELQVIEIDQGDGWTRVRREN 644
            ..|:...:|     |.|.:..:.|    :.:...:...:...:|..|.:.:....|.|     |.
Mouse   718 TAEHHTSDD-----ECEPIEAIAK----FDYVGRTARELSFKKGASLLLYQRASDDWW-----EG 768

  Fly   645 NSNGWDEGFVPTSYIEI 661
            ..||.| |.:|..||.:
Mouse   769 RHNGID-GLIPHQYIVV 784

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cip4	NP_001097501.1	F-BAR_CIP4-like	69..319	CDD:153337	59/295 (20%)
		HR1_CIP4-like	412..488	CDD:212009	20/103 (19%)
		SH3_CIP4-like	603..661	CDD:212844	13/57 (23%)
Srgap2	NP_001074480.2	F-BAR_srGAP2	26..289	CDD:153366	52/262 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	181..211		3/29 (10%)
		RhoGAP_srGAP	487..674	CDD:239848	28/204 (14%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	700..726		6/25 (24%)
		SH3_srGAP1-3	732..784	CDD:212888	13/61 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	795..819
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	838..918
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	984..1012
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1029..1071
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3565
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810