DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Cip4 and Trip10

DIOPT Version :9

Sequence 1:NP_001097501.1 Gene:Cip4 / 38534 FlyBaseID:FBgn0035533 Length:665 Species:Drosophila melanogaster
Sequence 2:NP_001229318.1 Gene:Trip10 / 106628 MGIID:2146901 Length:603 Species:Mus musculus


Alignment Length:657 Identity:223/657 - (33%)
Similarity:348/657 - (52%) Gaps:113/657 - (17%)


- Green bases have known domain annotations that are detailed below.


  Fly    65 MSWGTELWDQNENLAIHTNRGIDALDKFANFLRDRVAIETEYAGKLRRLVKNYQPKKKEEEDNE- 128
            |.||||||||.|.|..||..|:|.|||:..|:::|..:|..||.:||.|||.|.||:..::|.| 
Mouse     1 MDWGTELWDQFEVLERHTQWGLDLLDKYVKFVKERAEVEQAYAKQLRSLVKKYLPKRPTKDDPEV 65

  Fly   129 -FTSVQAFRNLLKEVGDLAGQREVVSESLQLQIIAGVTLLSKTLREERKKCLSDGATLQQNLTTQ 192
             |:..|:|..||:||.|.|||||:|:|||.:::...:...|:.:::|||....:|...||.|...
Mouse    66 KFSQQQSFVQLLQEVNDFAGQRELVAESLGIRVCLELAKYSQEMKQERKMHFQEGRRAQQQLENG 130

  Fly   193 LSSLDRAKRNYEKAYRDSEKAVDSYKRADMDLNLSRAEVERYKNVMTSKIQQSDDAKNEYANQLQ 257
            ...|:.:||.:|:..|::|||..:.:|.|.|:|.::|:||:.|.....:...::::|||||.|||
Mouse   131 FKQLENSKRKFERDCREAEKAAHTAERLDQDINATKADVEKAKQQAHLRNHMAEESKNEYAAQLQ 195

  Fly   258 KTNNLQQQHYSMLLPSVLNRLQELDEKR-TRGFREFIVGA-----ADVESSVAPIIARCMEGIVK 316
            :.|..|...|...:|.:.::||::||:| ||      :||     ::.|..|.|||.:|:||:..
Mouse   196 RFNRDQAHFYFSQMPQIFDKLQDMDERRATR------LGAGYGLLSEAELQVVPIIGKCLEGMKV 254

  Fly   317 AGESINEKEDTFKVIERYQSGFTPPRDIPFEDLSKC-----------DPDSVQDSHYSNSTSN-- 368
            |.||::.|.|:..:||.::|||..|.|:.|||.|:.           .||...:...::|.|.  
Mouse   255 AAESVDAKNDSQVLIELHKSGFARPGDLEFEDFSQVINRVPSDSSLGTPDGRPELRAASSRSRAK 319

  Fly   369 -------------HLTIRG-----TMS-------------------ANKLKKRVGIFNIFGSNKN 396
                         .|::.|     |:|                   :..:|.|:..|..|...:.
Mouse   320 RWPFGKKNKPRPPSLSLLGGHLPSTLSDGPSSPRSGRDPLAILSEISKSVKPRLASFRSFRGGRG 384

  Fly   397 SLTADGQKEDFSDLPPNQRRKKLQAKIAELTQNIAQETKARDGLMKMKIVYEANSSLGNPMTVEG 461
            ::..    ||||.|||.|:||:||.::.|..:.:.:|...|:.|.|||.|||....:|:|.::|.
Mouse   385 TVAT----EDFSHLPPEQQRKRLQQQLEERNRELQKEEDQREALKKMKDVYEKTPQMGDPASLEP 445

  Fly   462 QLNESEHKLEKLKVDLKKYQGFLEKASQVPTATSSPQASRNQLQNGHRTSRHSNGSADDHHDDGD 526
            ::.|:...:|:||::::||:.:|.:|.           ||.....|...|||:            
Mouse   446 RIAETLGNIERLKLEVQKYEAWLAEAE-----------SRVLSNRGDSLSRHA------------ 487

  Fly   527 DQPDDAGSLSRSDSEDNVAQIQNGHNNNNNGSASPESGLGTSHTSLPGSGQGSANENAIGEDTYY 591
             :|.|..:.:..||..:..   |..:.:|..|:|.|.         |..||.:.......||  :
Mouse   488 -RPPDPPTTAPPDSSSSST---NSGSQDNKESSSEEP---------PSEGQDTPIYTEFDED--F 537

  Fly   592 ETEVETLNPVGKCRALYPFEASSEGSIPMSEGEELQVIEIDQGDGWTRVRRENNSNGWDEGFVPT 656
            |   |..:|:|:|.|:|.||.||||::.|||||:|.::|.|:|||||||||:..:    ||:|||
Mouse   538 E---EPASPIGQCVAIYHFEGSSEGTVSMSEGEDLSLMEEDKGDGWTRVRRKQGA----EGYVPT 595

  Fly   657 SYIEITL 663
            ||:.:||
Mouse   596 SYLRVTL 602

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Cip4NP_001097501.1 F-BAR_CIP4-like 69..319 CDD:153337 101/257 (39%)
HR1_CIP4-like 412..488 CDD:212009 26/75 (35%)
SH3_CIP4-like 603..661 CDD:212844 33/57 (58%)
Trip10NP_001229318.1 Required for podosome formation and interaction with AKAP9 and microtubules. /evidence=ECO:0000250 1..117 54/115 (47%)
Required for translocation to the plasma membrane in response to insulin 1..117 54/115 (47%)
F-BAR_CIP4-like 5..257 CDD:153337 101/257 (39%)
Interaction with PDE6G. /evidence=ECO:0000250 293..603 104/359 (29%)
Interaction with CDC42. /evidence=ECO:0000250 293..539 66/290 (23%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 295..358 8/62 (13%)
HR1_CIP4_FNBP1L 395..475 CDD:212018 29/90 (32%)
Required for interaction with FASLG and localization to lysosomes. /evidence=ECO:0000250 471..603 60/177 (34%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 477..541 20/93 (22%)
Interaction with DNM2 and WASL. /evidence=ECO:0000269|PubMed:16418535 487..543 16/85 (19%)
Interaction with DNM1 and WASL. /evidence=ECO:0000250 532..603 41/80 (51%)
Required for podosome formation. /evidence=ECO:0000250 540..603 37/67 (55%)
Interaction with WAS. /evidence=ECO:0000250 546..603 35/61 (57%)
SH3_CIP4-like 546..600 CDD:212844 33/57 (58%)
Interaction with ARHGAP17, DAAM1, DIAPH1 and DIAPH2. /evidence=ECO:0000250 548..603 34/59 (58%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C167848147
Domainoid 1 1.000 208 1.000 Domainoid score I2853
eggNOG 1 0.900 - - E1_KOG3565
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 354 1.000 Inparanoid score I2233
Isobase 1 0.950 - 0 Normalized mean entropy S4360
OMA 1 1.010 - - QHG51860
OrthoDB 1 1.010 - - D348563at2759
OrthoFinder 1 1.000 - - FOG0001169
OrthoInspector 1 1.000 - - otm42608
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - LDO PTHR15735
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R2056
SonicParanoid 1 1.000 - - X890
SwiftOrtho 1 1.000 - -
TreeFam 1 0.960 - -
1615.850

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