Protein Alignment Cip4 and Trip10

DIOPT Version :10

• Sequence 1: NP_001097501.1
• Gene: Cip4 / 38534
• FlyBaseID: FBgn0035533
• Length: 665
• Species: Drosophila melanogaster
• Sequence 2: NP_001397222.1
• Gene: Trip10 / 106628
• MGIID: 2146901
• Length: 612
• Species: Mus musculus
• Alignment Length: 666
• Identity: 223/666 - (33%)
• Similarity: 349/666 - (52%)
• Gaps: 122/666 - (18%)

  Fly    65 MSWGTELWDQNENLAIHTNRGIDALDKFANFLRDRVAIETEYAGKLRRLVKNYQPKKKEEEDNE- 128
            |.||||||||.|.|..||..|:|.|||:..|:::|..:|..||.:||.|||.|.||:..::|.|
Mouse     1 MDWGTELWDQFEVLERHTQWGLDLLDKYVKFVKERAEVEQAYAKQLRSLVKKYLPKRPTKDDPEV 65

  Fly   129 -FTSVQAFRNLLKEVGDLAGQREVVSESLQLQIIAGVTLLSKTLREERKKCLSDGATLQQNLTTQ 192
             |:..|:|..||:||.|.|||||:|:|||.:::...:...|:.:::|||....:|...||.|...
Mouse    66 KFSQQQSFVQLLQEVNDFAGQRELVAESLGIRVCLELAKYSQEMKQERKMHFQEGRRAQQQLENG 130

  Fly   193 LSSLDRAKRNYEKAYRDSEKAVDSYKRADMDLNLSRAEVERYKNVMTSKIQQSDDAKNEYANQLQ 257
            ...|:.:||.:|:..|::|||..:.:|.|.|:|.::|:||:.|.....:...::::|||||.|||
Mouse   131 FKQLENSKRKFERDCREAEKAAHTAERLDQDINATKADVEKAKQQAHLRNHMAEESKNEYAAQLQ 195

  Fly   258 KTNNLQQQHYSMLLPSVLNRLQELDEKR-TRGFREFIVGA-----ADVESSVAPIIARCMEGIVK 316
            :.|..|...|...:|.:.::||::||:| ||      :||     ::.|..|.|||.:|:||:..
Mouse   196 RFNRDQAHFYFSQMPQIFDKLQDMDERRATR------LGAGYGLLSEAELQVVPIIGKCLEGMKV 254

  Fly   317 AGESINEKEDTFKVIERYQSGFTPPRDIPFEDLSKC-----------DPDSVQDSHYSNSTSN-- 368
            |.||::.|.|:..:||.::|||..|.|:.|||.|:.           .||...:...::|.|.
Mouse   255 AAESVDAKNDSQVLIELHKSGFARPGDLEFEDFSQVINRVPSDSSLGTPDGRPELRAASSRSRAK 319

  Fly   369 -------------HLTIRG-----TMS-------------------ANKLKKRVGIFNIFGSNKN 396
                         .|::.|     |:|                   :..:|.|:..|..|...:.
Mouse   320 RWPFGKKNKPRPPSLSLLGGHLPSTLSDGPSSPRSGRDPLAILSEISKSVKPRLASFRSFRGGRG 384

  Fly   397 SLTADGQKEDFSDLPPNQRRKKLQAKIAELTQNIAQETK---------ARDGLMKMKIVYEANSS 452
            ::..    ||||.|||.|:||:||.::.|..:.:.:|..         :|:.|.|||.|||....
Mouse   385 TVAT----EDFSHLPPEQQRKRLQQQLEERNRELQKEEDQRSRRTARWSREALKKMKDVYEKTPQ 445

  Fly   453 LGNPMTVEGQLNESEHKLEKLKVDLKKYQGFLEKASQVPTATSSPQASRNQLQNGHRTSRHSNGS 517
            :|:|.::|.::.|:...:|:||::::||:.:|.:|.           ||.....|...|||:
Mouse   446 MGDPASLEPRIAETLGNIERLKLEVQKYEAWLAEAE-----------SRVLSNRGDSLSRHA--- 496

  Fly   518 ADDHHDDGDDQPDDAGSLSRSDSEDNVAQIQNGHNNNNNGSASPESGLGTSHTSLPGSGQGSANE 582
                      :|.|..:.:..||..:..   |..:.:|..|:|.|.         |..||.:...
Mouse   497 ----------RPPDPPTTAPPDSSSSST---NSGSQDNKESSSEEP---------PSEGQDTPIY 539

  Fly   583 NAIGEDTYYETEVETLNPVGKCRALYPFEASSEGSIPMSEGEELQVIEIDQGDGWTRVRRENNSN 647
            ....||  :|   |..:|:|:|.|:|.||.||||::.|||||:|.::|.|:|||||||||:..:
Mouse   540 TEFDED--FE---EPASPIGQCVAIYHFEGSSEGTVSMSEGEDLSLMEEDKGDGWTRVRRKQGA- 598

  Fly   648 GWDEGFVPTSYIEITL 663
               ||:|||||:.:||
Mouse   599 ---EGYVPTSYLRVTL 611

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cip4	NP_001097501.1	F-BAR_CIP4-like	69..319	CDD:153337	101/257 (39%)
		HR1_CIP4-like	412..488	CDD:212009	26/84 (31%)
		SH3_CIP4-like	603..661	CDD:212844	33/57 (58%)
Trip10	NP_001397222.1	Required for podosome formation and interaction with AKAP9 and microtubules. /evidence=ECO:0000250	1..117		54/115 (47%)
		Required for translocation to the plasma membrane in response to insulin	1..117		54/115 (47%)
		F-BAR_CIP4-like	5..257	CDD:153337	101/257 (39%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	295..358		8/62 (13%)
		HR1_CIP4_FNBP1L	395..484	CDD:212018	29/99 (29%)
		Required for interaction with FASLG and localization to lysosomes. /evidence=ECO:0000250	480..612		60/177 (34%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	486..550		20/93 (22%)
		Interaction with DNM2 and WASL. /evidence=ECO:0000269|PubMed:16418535	496..552		16/85 (19%)
		Interaction with DNM1 and WASL. /evidence=ECO:0000250	541..612		41/80 (51%)
		Required for podosome formation. /evidence=ECO:0000250	549..612		37/67 (55%)
		Interaction with WAS. /evidence=ECO:0000250	555..612		35/61 (57%)
		SH3_CIP4-like	555..609	CDD:212844	33/57 (58%)
		Interaction with ARHGAP17, DAAM1, DIAPH1 and DIAPH2. /evidence=ECO:0000250	557..612		34/59 (58%)