DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cip4 and fchsd1

DIOPT Version :9

Sequence 1:	NP_001097501.1	Gene:	Cip4 / 38534	FlyBaseID:	FBgn0035533	Length:	665	Species:	Drosophila melanogaster
Sequence 2:	XP_002940037.4	Gene:	fchsd1 / 100489010	XenbaseID:	XB-GENE-6257860	Length:	770	Species:	Xenopus tropicalis

Alignment Length:	709	Identity:	145/709 - (20%)
Similarity:	264/709 - (37%)	Gaps:	203/709 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    24 HSAI----AFTCVRVCAKLLASGSSRSSSNNK----------LAESENSAQNSN----------- 63
            |||:    .|...|      |.|:.|...|.:          ||:.|..|::..
Frog     8 HSAVTLSNTFNTFR------AVGTQRFCGNGEAEVSVPDCEHLAQQERGAEDFGMQPPPRKVKAT 66

  Fly    64 ---NMSWGTELWD-QNENLAIHTNRGIDALDKFANFLRDRVAIETEYAGKLRRLVKNYQPK---K 121
               .:.:|.:|.. ||:.|     :..:.|:...:|.:.|.|||.||...|:||...|..:   :
Frog    67 QEVKVRFGEQLSSLQNKQL-----QDTELLEDIRSFCKQRAAIEKEYGQALQRLASQYLKRDWHR 126

  Fly   122 KEEEDNEFTSV-QAFRNLLKEVGDLAGQ---------REVVSESLQLQIIAGVTLLSKTLREERK 176
            .:.|.:|..|| ..:|::::....: ||         |.:.||:.:....|...||.|::.:..|
Frog   127 GKNETSECRSVYSVWRSVVEGTASI-GQTRVTGAENYRNLTSEAAKTARSAKELLLKKSIEQLLK 190

  Fly   177 KCLSDGATLQQNLTTQLSSLDRAKRNYEKAYRDS----EKAVDS---YKRADMDLNLSRAEVERY 234
                    :|..|...:..:::.|:.|.:..|.|    |||:|:   .|:::..:..|:|.:::.
Frog   191 --------VQNELLETMKEVNKTKKRYVQLERVSEVAKEKAMDTEARLKKSEHSIFHSKASLQKL 247

  Fly   235 KNVMTSKI----QQSDDAKNEYANQLQKTNNLQQQHYSMLLPSVLNRLQ-ELDEKRTRGFREFIV 294
            ....::::    ||..:|:|||...|...|.....:|...||.::..|. ::.::    ..:::.
Frog   248 SAKFSTQVVECNQQLSEARNEYLLALTAANAHLNHYYQTHLPDIMTCLDGDIYDR----LCDYLT 308

  Fly   295 GAADVESSVAPIIARCMEGIVKAGESINEKEDTFKVIERYQSGFTPPRDIPFEDLSKCDPDSVQD 359
            ..::.|.:.........:.|:.|.:.::.:::.               .:..:|.:...|..:|.
Frog   309 LISNTELNTCKFTQERFKDILVASQQVSRQQNL---------------QLFLKDTNLFSPTLIQK 358

  Fly   360 SHYSN----STSNHLTIRGTMSANKLKKRVGIFNIFGSNKNSLTADGQKEDFSDLPPNQRRKKLQ 420
            ...:.    ||...|| :|....:.|.|....:....:....|...|::.          .::|:
Frog   359 FQPAGSDKMSTLESLT-KGPNVESVLDKEARRWTSRAARDYKLKTHGERV----------LQRLE 412

  Fly   421 AKIAELTQNIAQETKARDGLMKMKIVYEANSSLGNPMTVEGQLNESEHKLE--KLKVDLKKYQGF 483
            ||.|         |.:.|.|..|::..|             ::.||..|.|  |:|.|.:
Frog   413 AKRA---------TVSEDELSSMELKTE-------------EVKESVRKAEVSKVKADAR----- 450

  Fly   484 LEKASQVPT-----ATSSPQASRNQLQNGHRTS--RHSNGSADDHHDDGD----DQPDDAGSLSR 537
            :|...||..     .|.:...:..:|:...|.|  |.|||......|:.|    ::.||
Frog   451 VELLRQVGVDVDMWLTGAMMQANAELEQERRMSEARMSNGELSPTMDEFDFTDFEECDD------ 509

  Fly   538 SDSEDNVAQIQNGHNNNNNGSASPESGLGTSHTSLPGSGQGSANENAIGEDTYYETEVETLNPVG 602
                              ||....||.|                 |..|...|         |.
Frog   510 ------------------NGEIFEESSL-----------------NLSGSRPY---------PF- 529

  Fly   603 KCRALYPFEASSEGSIPMSEGEELQVIEIDQGDGWTRVRRENNSNGWDEGFVPTSYIEI 661
            .|:.||.:::|....:.:::||:|:|||....:.|.:.|   |.:| ..|:||..||.|
Frog   530 PCQVLYSYQSSQSDELSITQGEQLEVIEDGDVEEWVKAR---NKSG-QVGYVPERYITI 584

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cip4	NP_001097501.1	F-BAR_CIP4-like	69..319	CDD:153337	59/275 (21%)
		HR1_CIP4-like	412..488	CDD:212009	17/77 (22%)
		SH3_CIP4-like	603..661	CDD:212844	19/57 (33%)
fchsd1	XP_002940037.4	F-BAR_FCHSD1	71..333	CDD:153362	60/279 (22%)
		SH3_FCHSD_1	528..584	CDD:212695	20/60 (33%)
		SH3_FCHSD_2	625..681	CDD:212696
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D348563at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2056
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.950