DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG15014 and Thumpd1

DIOPT Version :9

Sequence 1:	NP_647892.1	Gene:	CG15014 / 38533	FlyBaseID:	FBgn0035532	Length:	324	Species:	Drosophila melanogaster
Sequence 2:	NP_663560.1	Gene:	Thumpd1 / 233802	MGIID:	2444479	Length:	350	Species:	Mus musculus

Alignment Length:	368	Identity:	116/368 - (31%)
Similarity:	178/368 - (48%)	Gaps:	83/368 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 EPASKKSKMGKNVKFNNNKKKYFHAKR---------QTLQPGQRGFFATCNINEKACVRECYNLL 57
            :|.:.|.|         .|.::..|||         :.|:||.:|...|||:||:.||.|.|:||
Mouse    10 QPVAGKRK---------GKSQFLPAKRARRGDAGGPRQLEPGLQGILITCNMNERKCVEEAYSLL 65

  Fly    58 NHYADILYGSEKPENEPEKKQPEEGAGGDAGEDDPKPAAGGTSDDDDDLEAAAAK----CREMLS 118
            |.|.|.:||   ||...:|.|...|:.|                :|||.|||..|    .:....
Mouse    66 NEYGDDMYG---PEKFIDKDQQPSGSEG----------------EDDDAEAALKKEVGDIKASTE 111

  Fly   119 QRKMRFQNVDTNTTNCVFIRTQLEDPVALGKHIINDIATTGKSMSRFVLRLVPIEVVCRANMPDI 183
            :|..|||:|::...|.|||||...:|..|..||:.|:..|.|..:|.:||::||...|:|.:.|:
Mouse   112 KRLRRFQSVESGANNVVFIRTLGIEPEKLVHHILQDMYKTKKKKTRVILRMLPISGTCKAFLEDM 176

  Fly   184 ITAAGELFDKHFLKEPT--SYGIIFNHRYNQQIKRDQIITQLAELVNSKNVGNKVDLKEAKKSII 246
            ...| |.|.:.:.|.|.  ::.|::..|.|..:.|:::|.:||.:|.|.|..|||||...:.:::
Mouse   177 KKYA-ETFLEPWFKAPNKGTFQIVYKSRNNSHMNREEVIKELAGIVGSLNSENKVDLTNPEYTVV 240

  Fly   247 VEVLRGWCLLSVIDNYLECKKFNLAEL------ANPSDKKSSG-----EGDSK------------ 288
            ||:::..|.|||:.:|:..:|:||.|:      :.|..|..:|     |.|||
Mouse   241 VEIIKAVCCLSVVKDYVLFRKYNLQEVVKSAKDSQPHPKLGNGKEAKLEPDSKLSQSDPPEGNQV 305

  Fly   289 --------------SETSEVANGNDKEQAES--SEESKSNDDE 315
                          |||...:.|:.|.:.||  ||..|:|::|
Mouse   306 APESIEELGQTEPGSETQAGSEGDAKPEPESQVSEVPKTNENE 348

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG15014	NP_647892.1	THUMP_THUMPD1_like	123..260	CDD:212586	51/138 (37%)
Thumpd1	NP_663560.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..42		8/40 (20%)
		THUMP_THUMPD1_like	45..254	CDD:212586	82/228 (36%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	75..96		9/36 (25%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	270..350		19/79 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167849409
Domainoid	1	1.000	67	1.000	Domainoid score	I9814
eggNOG	1	0.900	-	-		E1_COG1818
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H5878
Inparanoid	1	1.050	161	1.000	Inparanoid score	I4215
Isobase	1	0.950	-	0	Normalized mean entropy	S3344
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0004286
OrthoInspector	1	1.000	-	-		oto93038
orthoMCL	1	0.900	-	-		OOG6_102910
Panther	1	1.100	-	-	LDO	PTHR13452
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1712
SonicParanoid	1	1.000	-	-		X4662
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	15	14.730