Protein Alignment PMP34 and UCP1

DIOPT Version :10

• Sequence 1: NP_728982.1
• Gene: PMP34 / 38532
• FlyBaseID: FBgn0052250
• Length: 314
• Species: Drosophila melanogaster
• Sequence 2: NP_068605.1
• Gene: UCP1 / 7350
• HGNCID: 12517
• Length: 307
• Species: Homo sapiens
• Alignment Length: 305
• Identity: 71/305 - (23%)
• Similarity: 128/305 - (41%)
• Gaps: 45/305 - (14%)

  Fly    17 VHAVSGAAGGCIAMSTFYPLDTVRSRLQLEEAGDVRSTRQVIKEIVLG--------EGFQSLYRG 73
            |...|.....|:|....:||||.:.|||::  |:..::..:..:.|||        ||...||.|
Human    15 VQLFSAGIAACLADVITFPLDTAKVRLQVQ--GECPTSSVIRYKGVLGTITAVVKTEGRMKLYSG 77

  Fly    74 LGPVLQSLCISNFVYFYTFHALKAVASGGSPSQHSALKDLLLGSIAGIINVLTTTPFWVVNTRLR 138
            |...||....|..:....:..::...:.|..:..|....:|.|...|.:.|....|..||..||:
Human    78 LPAGLQRQISSASLRIGLYDTVQEFLTAGKETAPSLGSKILAGLTTGGVAVFIGQPTEVVKVRLQ 142

  Fly   139 MR-NVAGTSDEVNKHYKNLLEGLKYVAEKEGIAGLWSGTIPSLM--LVSNPALQFMMYEML---- 196
            .: ::.|    :...|.......:.:|..||:.|||.||.|:||  ::.| ..:.:.|:::
Human   143 AQSHLHG----IKPRYTGTYNAYRIIATTEGLTGLWKGTTPNLMRSVIIN-CTELVTYDLMKEAF 202

  Fly   197 -KRNIMRFTGGEMGSLSFFFIGAIAKAF-ATVLTYPLQLVQTKQRHRSKESDSKPSTSAGSTP-R 258
             |.||:      ...:....:.|:...| ||.::.|:.:|:|:              ...|.| :
Human   203 VKNNIL------ADDVPCHLVSALIAGFCATAMSSPVDVVKTR--------------FINSPPGQ 247

  Fly   259 TESTLELMISILQHQGIRGLFRGLEAKILQTVLTAALMFMAYEKI 303
            .:|.....:.:..::|....|:||....|:......:||:.:|::
Human   248 YKSVPNCAMKVFTNEGPTAFFKGLVPSFLRLGSWNVIMFVCFEQL 292

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PMP34	NP_728982.1	Mito_carr	15..96	CDD:395101	24/86 (28%)
		Mito_carr	105..202	CDD:395101	28/104 (27%)
		Mito_carr	214..303	CDD:395101	18/90 (20%)
UCP1	NP_068605.1	Mito_carr	10..104	CDD:395101	24/90 (27%)
		Solcar 1	11..102		24/88 (27%)
		Mito_carr	111..206	CDD:395101	26/99 (26%)
		Solcar 2	111..201		25/94 (27%)
		Solcar 3	210..295		18/97 (19%)
		Mito_carr	215..300	CDD:395101	18/92 (20%)